4.6 Review

Electrochemotherapy: An Alternative Strategy for Improving Therapy in Drug-Resistant SOLID Tumors

Related references

Note: Only part of the references are listed.
Article Biochemical Research Methods

Therapeutic Potential of MF-TTZ-MMAE, a Site-Specifically Conjugated Antibody-Drug Conjugate, for the Treatment of HER2-Overexpressing Breast Cancer

Ludovic Juen et al.

Summary: This study successfully developed a HER2-targeting antibody-drug conjugate using a new bioconjugation technology. The conjugate showed high homogeneity and excellent stability, and demonstrated superior efficacy compared to a clinically approved antibody-drug conjugate in a mouse model, indicating its therapeutic potential.

BIOCONJUGATE CHEMISTRY (2022)

Article Pharmacology & Pharmacy

Recent advances in anti-multidrug resistance for nano-drug delivery system

Changduo Wang et al.

Summary: Chemotherapy often fails due to drug resistance. To overcome this, researchers have developed a functional nano-drug delivery system (NDDS) that enhances the sensitivity of anticancer drugs and reduces side effects. This review explores the causes of multidrug resistance (MDR), highlights the applications of NDDS, and discusses future directions in this field.

DRUG DELIVERY (2022)

Review Oncology

Chemoprotective and chemosensitizing effects of apigenin on cancer therapy

Zahra Nozhat et al.

Summary: The review focuses on the combinatorial strategies involving apigenin in cancer therapeutics, highlighting its potential to enhance anti-cancer effects, reduce side effects, overcome drug resistance, and protect healthy cells when combined with chemotherapy drugs.

CANCER CELL INTERNATIONAL (2021)

Article Pharmacology & Pharmacy

Electrochemotherapy with Calcium Chloride and 17β-Estradiol Modulated Viability and Apoptosis Pathway in Human Ovarian Cancer

Zofia Lapinska et al.

Summary: The study found that pre-incubation of ovarian cancer cells with 17 beta-estradiol may effectively enhance the chemo- and electrochemotherapy with cisplatin and calcium chloride, but it reduces the effectiveness of electroporation, indicating that the mechanism of increasing the effectiveness of ECT by E-2 is not related to the change of cell membrane permeability.

PHARMACEUTICS (2021)

Article Oncology

Debulking mastectomy with electrochemotherapy: a case report of no surgery approach to recurrent breast cancer

Emanuela Esposito et al.

Summary: Electrochemotherapy has been proven as a safe and effective treatment for chest wall breast cancer recurrence, offering a palliative option for patients with cutaneous metastases from breast cancer. The use of electrochemotherapy in this case allowed for necrosis of the remaining breast tissue without the need for surgery, providing an alternative to palliative mastectomy for selected patients. New technologies, such as this breakthrough application of electrochemotherapy, may help clinicians find treatment options that align with patient preferences and help avoid invasive surgeries in certain cases.

TRANSLATIONAL CANCER RESEARCH (2021)

Review Oncology

Electrochemotherapy in Mucosal Cancer of the Head and Neck: A Systematic Review

Primoz Strojan et al.

Summary: Electrochemotherapy, based on reversible electroporation and intracellular accumulation of hydrophilic drug molecules, is considered an effective and safe treatment for tumors, including mucosal cancer of the head and neck. Limited experience with ECT in mucosal HNC due to poor accessibility of tumors highlights the need for further research to confirm its potential as a treatment option in selected patients.

CANCERS (2021)

Review Cell Biology

Impacts of Environmental Factors on Head and Neck Cancer Pathogenesis and Progression

Marisol Miranda-Galvis et al.

Summary: Environmental factors and genetic elements interact to influence one's susceptibility to cancer, particularly in the pathogenesis and progression of head and neck cancer. Latest research and treatment strategies emphasize the importance of gene-environment interactions, aiming to inhibit environmental drivers of tumor progression and improve survival outcomes for patients.

CELLS (2021)

Article Biochemistry & Molecular Biology

The Inhibitory Activity of Curcumin on P-Glycoprotein and Its Uptake by and Efflux from LS180 Cells Is Not Affected by Its Galenic Formulation

Sandra Flory et al.

Summary: The study found that curcumin inhibits P-glycoprotein activity regardless of formulation, and the uptake and efflux of curcumin from intestinal cells showed variability between formulations but did not significantly impact its bioavailability.

ANTIOXIDANTS (2021)

Review Oncology

Electrochemotherapy in Vulvar Cancer and Cisplatin Combined with Electroporation. Systematic Review and In Vitro Studies

Anna Myriam Perrone et al.

Summary: Electrochemotherapy (ECT) is an emerging treatment for solid tumors that involves maximizing the action of specific cytotoxic drugs through the tumor-directed delivery of non-ablative electrical pulses. Despite mainly being recommended for palliative care, ECT has the potential to improve patient outcomes by preventing or delaying tumor progression. Additionally, the efficacy of different drugs in ECT, such as cisplatin and bleomycin, should be compared through systematic literature reviews to explore the possibilities of overcoming chemoresistance and improving local control.

CANCERS (2021)

Review Oncology

Electrochemotherapy in the Treatment of Head and Neck Cancer: Current Conditions and Future Directions

Tomohiro Enokida et al.

Summary: Electrochemotherapy (ECT) is a new treatment modality for head and neck cancer, combining locally applied electric pulses with antineoplastic agents. It has shown promising efficacy and tolerable safety profile in clinical studies, making it a potential strategy for heavily pre-treated HNC patients. Efforts to improve its efficacy and expand its application are ongoing, with the combination of ECT with novel therapies like immune checkpoint inhibitors showing theoretical promise. Extensive, well-organized clinical studies and updated consensus guidelines are needed to bring this hopeful treatment to challenging situations in HNC patients.

CANCERS (2021)

Review Biochemistry & Molecular Biology

Control of Oxidative Stress in Cancer Chemoresistance: Spotlight on Nrf2 Role

Giuseppina Barrera et al.

Summary: Chemoresistance poses a significant challenge to cancer treatment by affecting the efficacy of conventional and targeted therapies. Metabolic remodeling, particularly the control of redox status, and the upregulation of antioxidant systems contribute to cancer cell survival post-therapy. The master regulator Nrf2, along with other transcription factors, plays crucial roles in maintaining high antioxidant levels in chemoresistant cancer cells.

ANTIOXIDANTS (2021)

Article Biochemistry & Molecular Biology

PARP inhibitor olaparib has a potential to increase the effectiveness of electrochemotherapy in BRCA1 mutated breast cancer in mice

Masa Bosnjak et al.

Summary: The study demonstrates that combining PARP inhibitor olaparib with electrochemotherapy (ECT) can enhance the therapeutic effectiveness in BRCA1 mutated breast cancer cells, but has minimal effect on non-mutated cells, indicating repetitive treatment may be necessary.

BIOELECTROCHEMISTRY (2021)

Article Oncology

Electrochemotherapy with Mitomycin C Potentiates Apoptosis Death by Inhibiting Autophagy in Squamous Carcinoma Cells

Maria Condello et al.

Summary: The study confirmed the potentiating effect of electroporation (EP) combined with mitomycin C (MMC) treatment on oral and laryngeal cancer cells, showing that EP enhances MMC cytotoxicity by inhibiting the autophagic process induced by the drug in favor of apoptosis. Both in vitro and clinical applications demonstrated the efficacy, tolerability, and feasibility of EP plus MMC treatment, indicating a promising therapeutic strategy for overcoming drug resistance in solid tumors.

CANCERS (2021)

Review Biochemistry & Molecular Biology

Small molecules in targeted cancer therapy: advances, challenges, and future perspectives

Lei Zhong et al.

Summary: Targeted therapeutic drugs have become mainstream cancer treatments due to their advantages in efficacy and safety, but still face challenges such as low response rate and drug resistance. A comprehensive review was conducted on small-molecule targeted anti-cancer drugs to promote their development, discussing current challenges and providing insights and perspectives for future research and development.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Review Oncology

Literature Review and Our Experience With Bleomycin-Based Electrochemotherapy for Cutaneous Vulvar Metastases From Endometrial Cancer

Sebastjan Merlo et al.

Summary: Endometrial carcinoma is a common malignancy in women, with the possibility of cutaneous metastases. Treatment typically involves a multimodal approach including surgery, chemotherapy, and other therapies. Electrochemotherapy may be an effective and safe option for treating multiple skin metastases.

TECHNOLOGY IN CANCER RESEARCH & TREATMENT (2021)

Article Chemistry, Applied

Analysis of Pathways in Triple-Negative Breast Cancer Cells Treated with the Combination of Electrochemotherapy and Cisplatin

Pragatheiswar Giri et al.

Summary: Breast cancer remains one of the deadliest cancers worldwide, with Triple Negative Breast Cancer (TNBC) being particularly difficult to treat and prone to recurrence. Scientists are currently studying the combination of electrochemotherapy with cisplatin as a potential treatment for TNBC, aiming to modulate protein activity pathways.

BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY (2021)

Review Oncology

Insights into new mechanisms and models of cancer stem cell multidrug resistance

Y. Garcia-Mayea et al.

SEMINARS IN CANCER BIOLOGY (2020)

Article Anesthesiology

Anesthetic Management in Electrochemotherapy

Christian Volberg et al.

ANASTHESIOLOGIE INTENSIVMEDIZIN NOTFALLMEDIZIN SCHMERZTHERAPIE (2020)

Review Biochemistry & Molecular Biology

Targeting MAPK Signaling in Cancer: Mechanisms of Drug Resistance and Sensitivity

Shannon Lee et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Genetics & Heredity

Clinical implications of intratumor heterogeneity: challenges and opportunities

Santiago Ramon y Cajal et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2020)

Review Oncology

Perplexing Role of P-Glycoprotein in Tumor Microenvironment

Kianna Robinson et al.

FRONTIERS IN ONCOLOGY (2020)

Article Biochemistry & Molecular Biology

Cancellation effect is present in high-frequency reversible and irreversible electroporation

Tamara Polajzer et al.

BIOELECTROCHEMISTRY (2020)

Review Biochemistry & Molecular Biology

Mechanisms of Multidrug Resistance in Cancer Chemotherapy

Karol Bukowski et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Pharmacology & Pharmacy

The Exploitation of Liposomes in the Inhibition of Autophagy to Defeat Drug Resistance

Maria Condello et al.

FRONTIERS IN PHARMACOLOGY (2020)

Review Cell Biology

RNA delivery by extracellular vesicles in mammalian cells and its applications

Killian O'Brien et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Review Radiology, Nuclear Medicine & Medical Imaging

A Review of the Mechanisms and Clinical Implications of Precision Cancer Therapy-Related Toxicity: A Primer for the Radiologist

Richard Thomas et al.

AMERICAN JOURNAL OF ROENTGENOLOGY (2020)

Review Oncology

Ovarian cancer predisposition beyond BRCA1 and BRCA2 genes

Antonella Pietragalla et al.

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2020)

Review Oncology

Exosomes: A Source for New and Old Biomarkers in Cancer

Mariantonia Logozzi et al.

CANCERS (2020)

Review Biochemistry & Molecular Biology

Role of Nucleotide Excision Repair in Cisplatin Resistance

Mingrui Duan et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Medicine, General & Internal

Head and neck squamous cell carcinoma

Daniel E. Johnson et al.

NATURE REVIEWS DISEASE PRIMERS (2020)

Review Oncology

Cervical cancer: Epidemiology, risk factors and screening

Shaokai Zhang et al.

CHINESE JOURNAL OF CANCER RESEARCH (2020)

Article Gastroenterology & Hepatology

Electrochemotherapy for colorectal cancer using endoscopic electroporation: a phase 1 clinical study

Hanne Falk Hansen et al.

ENDOSCOPY INTERNATIONAL OPEN (2020)

Review Gastroenterology & Hepatology

Advances in immunotherapy for colorectal cancer: a review

Gol Golshani et al.

THERAPEUTIC ADVANCES IN GASTROENTEROLOGY (2020)

Review Biochemistry & Molecular Biology

Comprehensive review of targeted therapy for colorectal cancer

Yuan-Hong Xie et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Review Oncology

Resistance and Overcoming Resistance in Breast Cancer

Andrea Luque-Bolivar et al.

BREAST CANCER-TARGETS AND THERAPY (2020)

Review Biophysics

Membrane Electroporation and Electropermeabilization: Mechanisms and Models

Tadej Kotnik et al.

ANNUAL REVIEW OF BIOPHYSICS, VOL 48 (2019)

Review Biochemistry & Molecular Biology

Exosomes: biogenesis, biologic function and clinical potential

Yuan Zhang et al.

CELL AND BIOSCIENCE (2019)

Review Biochemistry & Molecular Biology

Therapy resistance mediated by exosomes

Teresa Bernadette Steinbichler et al.

MOLECULAR CANCER (2019)

Editorial Material Cell Biology

Interplay between ROS and Autophagy in Cancer and Aging: From Molecular Mechanisms to Novel Therapeutic Approaches

Marco Cordani et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

Article Veterinary Sciences

Electrochemotherapy in Veterinary Oncology State-of-the-Art and Perspectives

Enrico Pierluigi Spugnini et al.

VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE (2019)

Article Physiology

The Acidic Tumor Microenvironment as a Driver of Cancer

Ebbe Boedtkjer et al.

Annual Review of Physiology (2019)

Review Health Care Sciences & Services

Electrochemotherapy: A Review of Current Status, Alternative IGP Approaches, and Future Perspectives

Nazila Esmaeili et al.

JOURNAL OF HEALTHCARE ENGINEERING (2019)

Review Gastroenterology & Hepatology

Epidemiology of colorectal cancer: incidence, mortality, survival, and risk factors

Prashanth Rawla et al.

GASTROENTEROLOGY REVIEW-PRZEGLAD GASTROENTEROLOGICZNY (2019)

Review Oncology

Tumour heterogeneity and resistance to cancer therapies

Ibiayi Dagogo-Jack et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

Article Biochemistry & Molecular Biology

Investigation of the chemical mechanisms involved in the electropulsation of membranes at the molecular level

Marie Breton et al.

BIOELECTROCHEMISTRY (2018)

Review Biochemistry & Molecular Biology

In vitro electroporation detection methods - An overview

Tina Batista Napotnik et al.

BIOELECTROCHEMISTRY (2018)

Article Oncology

Effect of Electrode Distance in Grid Electrode: Numerical Models and In Vitro Tests

Alessia Ongaro et al.

TECHNOLOGY IN CANCER RESEARCH & TREATMENT (2018)

Article Biotechnology & Applied Microbiology

Electroporation with Cisplatin against Metastatic Pancreatic Cancer: In Vitro Study on Human Primary Cell Culture

Olga Michel et al.

BIOMED RESEARCH INTERNATIONAL (2018)

Review Oncology

The hypoxic tumour microenvironment

Varvara Petrova et al.

ONCOGENESIS (2018)

Article Otorhinolaryngology

Electrochemotherapy: a well-accepted palliative treatment by patients with head and neck tumours

B. Pichi et al.

ACTA OTORHINOLARYNGOLOGICA ITALICA (2018)

Review Biochemistry & Molecular Biology

Effect of Stromal Cells in Tumor Microenvironment on Metastasis Initiation

Sen Guo et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2018)

Article Veterinary Sciences

Ultrasound guided electrochemotherapy for the treatment of a clear cell thymoma in a cat

Enrico Pierluigi Spugnini et al.

OPEN VETERINARY JOURNAL (2017)

Article Biochemistry & Molecular Biology

Inhibition of autophagy sensitises cells to hydrogen peroxide-induced apoptosis: Protective effect of mild thermotolerance acquired at 40 °C

Maureen Redza-Dutordoir et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2016)

Review Engineering, Biomedical

Electrochemotherapy: from the drawing board into medical practice

Damijan Miklavcic et al.

BIOMEDICAL ENGINEERING ONLINE (2014)

Review Neurosciences

Apoptosis and Oxidative Stress in Neurodegenerative Diseases

Elena Radi et al.

JOURNAL OF ALZHEIMERS DISEASE (2014)

Article Cell Biology

Definition of Novel Electrochemotherapy Parameters and Validation of their in Vitro and in Vivo Effectiveness

Enrico P. Spugnini et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2014)

Review Pharmacology & Pharmacy

Physically facilitating drug-delivery systems

Jorge I. Rodriguez-Devora et al.

THERAPEUTIC DELIVERY (2012)

Article Medicine, Research & Experimental

Electroporation increases antitumoral efficacy of the bcl-2 antisense G3139 and chemotherapy in a human melanoma xenograft

Enrico P. Spugnini et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2011)

Review Biotechnology & Applied Microbiology

Sarcoplasmic reticulum Ca2+ ATPase as a therapeutic target for heart failure

Larissa Lipskaia et al.

EXPERT OPINION ON BIOLOGICAL THERAPY (2010)

Review Cell Biology

Mitochondria and cell death: outer membrane permeabilization and beyond

Stephen W. G. Tait et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)

Article Anatomy & Morphology

Ultrastructural modifications of cell membranes induced by Electroporation on melanoma xenografts

Enrico P. Spugnini et al.

MICROSCOPY RESEARCH AND TECHNIQUE (2007)

Article Medicine, Research & Experimental

Electrochemotherapy in primary and metastatic skin tumors:: Phase II trial using intralesional bleomycin

S Rodríguez-Cuevas et al.

ARCHIVES OF MEDICAL RESEARCH (2001)

Article Gastroenterology & Hepatology

Electrochemotherapy for colorectal cancer with commonly used chemotherapeutic agents in a mouse model

S Kuriyama et al.

DIGESTIVE DISEASES AND SCIENCES (2000)