4.6 Article

A LETM2-Regulated PI3K-Akt Signaling Axis Reveals a Prognostic and Therapeutic Target in Pancreatic Cancer

Related references

Note: Only part of the references are listed.
Article Cell Biology

Emerging role of LETM1/GRP78 axis in lung cancer

Quangdon Tran et al.

Summary: The study found that LETM1 is overexpressed in lung cancer cells, leading to fragmentation of mitochondria and upregulation of mitophagy. Glucose-regulated protein 78 (GRP78) was found to interact with LETM1, and this interaction was enhanced in cells treated with a mitophagy-inducing chemical. Furthermore, the study showed that honokiol, a GRP78 inhibitor, blocked LETM1-mediated mitophagy, and CRISPR/Cas9-mediated GRP75 knockout inhibited LETM1-induced autophagy.

CELL DEATH & DISEASE (2022)

Article Oncology

Nuclear FGFR1 Regulates Gene Transcription and Promotes Antiestrogen Resistance in ER+ Breast Cancer

Alberto Servetto et al.

Summary: FGFR1 overexpression in the nucleus of breast cancer cells is associated with endocrine resistance in ER+ breast cancer. Nuclear FGFR1 influences gene transcription and promotes resistance to estrogen suppression and fulvestrant. Treatment with FGFR tyrosine kinase inhibitors does not affect nuclear FGFR1 activity, supporting the development of strategies to inhibit nuclear FGFR1 in ER+/FGFR1 overexpressing breast cancer.

CLINICAL CANCER RESEARCH (2021)

Review Biotechnology & Applied Microbiology

PI3K inhibitors are finally coming of age

Bart Vanhaesebroeck et al.

Summary: Overactive PI3K is a frequently activated pathway in cancer, but therapeutic PI3K pathway inhibitors face challenges such as poor drug tolerance and resistance. Several targeted PI3K inhibitors have received regulatory approval, and their potential in cancer immunotherapy has been highlighted.

NATURE REVIEWS DRUG DISCOVERY (2021)

Article Biochemistry & Molecular Biology

GEPIA2021: integrating multiple deconvolution-based analysis into GEPIA

Chenwei Li et al.

Summary: GEPIA2021 is a standalone extension of GEPIA, allowing users to perform cell type-level analysis and survival analysis, helping experimental biologists validate hypotheses and explore large datasets.

NUCLEIC ACIDS RESEARCH (2021)

Review Oncology

Targeting PI3K Pathway in Pancreatic Ductal Adenocarcinoma: Rationale and Progress

Siddharth Mehra et al.

Summary: Pancreatic cancer has a low survival rate and strong resistance to treatment, making targeted inhibition of the PI3K/Akt/mTOR pathway crucial for reducing tumor burden and improving survival. Targeted therapy against PI3K signaling has shown significant impact on modulating tumor-stromal-immune interactions within the microenvironment of pancreatic cancer.

CANCERS (2021)

Review Cell Biology

Mitochondria as multifaceted regulators of cell death

Florian J. Bock et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Review Biochemistry & Molecular Biology

Current advances and outlooks in immunotherapy for pancreatic ductal adenocarcinoma

Jia-qiao Fan et al.

MOLECULAR CANCER (2020)

Article Gastroenterology & Hepatology

Early Detection of Pancreatic Cancer: Opportunities and Challenges

Aatur D. Singhi et al.

GASTROENTEROLOGY (2019)

Review Biochemistry & Molecular Biology

Targeting PI3K in cancer: mechanisms and advances in clinical trials

Jing Yang et al.

MOLECULAR CANCER (2019)

Review Biochemistry & Molecular Biology

LETM1: Essential for Mitochondrial Biology and Cation Homeostasis?

Shane Austin et al.

TRENDS IN BIOCHEMICAL SCIENCES (2019)

Review Oncology

PI3K/Akt/mTOR inhibitors in cancer: At the bench and bedside

Ali S. Alzahrani

SEMINARS IN CANCER BIOLOGY (2019)

Article Gastroenterology & Hepatology

Combating pancreatic cancer with PI3K pathway inhibitors in the era of personalised medicine

James R. W. Conway et al.

Review Biochemistry & Molecular Biology

Molecular Mechanisms of Leucine Zipper EF-Hand Containing Transmembrane Protein-1 Function in Health and Disease

Qi-Tong Lin et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Oncology

Cancer Statistics, 2018

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2018)

Review Gastroenterology & Hepatology

Therapeutic developments in pancreatic cancer: current and future perspectives

John P. Neoptolemos et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2018)

Review Biochemistry & Molecular Biology

The PI3K Pathway in Human Disease

David A. Fruman et al.

Article Oncology

The FGFR Landscape in Cancer: Analysis of 4,853 Tumors by Next-Generation Sequencing

Teresa Helsten et al.

CLINICAL CANCER RESEARCH (2016)

Article Genetics & Heredity

Whole-Genome Sequencing Reveals Diverse Models of Structural Variations in Esophageal Squamous Cell Carcinoma

Caixia Cheng et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2016)

Review Oncology

Targeting the PI3K/Akt pathway in prostate cancer: Challenges and opportunities (Review)

Paul Toren et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2014)

Article Multidisciplinary Sciences

Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death

Hakryul Jo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Review Oncology

Mitochondria and cancer

Douglas C. Wallace

NATURE REVIEWS CANCER (2012)

Article Medicine, General & Internal

Pancreatic cancer

Audrey Vincent et al.

LANCET (2011)

Article Multidisciplinary Sciences

Inhibitor-Sensitive FGFR1 Amplification in Human Non-Small Cell Lung Cancer

Amit Dutt et al.

PLOS ONE (2011)

Review Gastroenterology & Hepatology

Epidemiology of pancreatic cancer: an overview

Sara Raimondi et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2009)

Review Genetics & Heredity

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

Jeffrey A. Engelman et al.

NATURE REVIEWS GENETICS (2006)

Article Oncology

Incidence, mechanism and prognostic value of activated AKT in pancreas cancer

MG Schlieman et al.

BRITISH JOURNAL OF CANCER (2003)

Article Biochemistry & Molecular Biology

The human genome browser at UCSC

WJ Kent et al.

GENOME RESEARCH (2002)