4.6 Article

Genetic Stability of Driver Alterations in Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type and Their Relapses: A Rationale for the Use of Molecular-Based Methods for More Effective Disease Monitoring

Related references

Note: Only part of the references are listed.
Article Hematology

Molecular features encoded in the ctDNA reveal heterogeneity and predict outcome in high-risk aggressive B-cell lymphoma

Leo Meriranta et al.

Summary: Liquid biopsy has important clinical significance in high-risk DLBCL patients, as it can reveal hidden clinical and biological heterogeneity, predict the risk of relapse and death, and provide molecular information for treatment decisions.

BLOOD (2022)

Article Pathology

Cell-of-origin classification using the Hans and Lymph2Cx algorithms in primary cutaneous large B-cell lymphomas

Anne M. R. Schrader et al.

Summary: This study compared the COO classification of two different types of primary cutaneous B-cell lymphoma (PCDLBCL-LT and PCFCL-LC) and found that their classification results were different. PCFCL-LC was almost always classified as the GCB subtype, while the classification of PCDLBCL-LT was more heterogeneous. However, these different classification results were not associated with the expression of BCL2 and IgM, gene mutations, gene loss, or patient survival.

VIRCHOWS ARCHIV (2022)

Article Oncology

Effect of ibrutinib with R-CHOP chemotherapy in genetic subtypes of DLBCL

Wyndham H. Wilson et al.

Summary: In younger patients with non-GCB DLBCL, the addition of ibrutinib to R-CHOP chemotherapy improves survival rates, particularly in patients with MCD and N1 subtypes. This study provides mechanistic understanding of the benefit of ibrutinib in this patient population.

CANCER CELL (2021)

Article Multidisciplinary Sciences

Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture

Nevin Yusufova et al.

Summary: Mutations in histone H1 play a significant role in driving malignant transformation in lymphomas through remodeling of chromatin structure, leading to changes in epigenetic states and de-repression of developmentally silenced genes. This study establishes H1 as a tumor suppressor and highlights its involvement in three-dimensional genome reorganization, ultimately contributing to aggressive lymphomas with increased repopulating potential.

NATURE (2021)

Article Pathology

Double expressor and double/triple hit status among primary cutaneous diffuse large B-cell lymphoma: a comparison between leg type and not otherwise specified subtypes

Marco Lucioni et al.

Summary: pcDLBCLs can be classified into pcDLBCL-LT and pcDLBCL-NOS, and the impact of DE and DH/TH status on prognosis needs further confirmation with more studies.

HUMAN PATHOLOGY (2021)

Article Biochemistry & Molecular Biology

Molecular Mechanisms of Disease Progression in Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type during Ibrutinib Therapy

Lucy C. Fox et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Dermatology

Genomic Analyses Identify Recurrent Alterations in Immune Evasion Genes in Diffuse Large B-Cell Lymphoma, Leg Type

Xiaolong Alan Zhou et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2018)

Article Medicine, General & Internal

Genetics and Pathogenesis of Diffuse Large B-Cell Lymphoma

R. Schmitz et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Oncology

Circulating Tumor DNA Measurements As Early Outcome Predictors in Diffuse Large B-Cell Lymphoma

David M. Kurtz et al.

JOURNAL OF CLINICAL ONCOLOGY (2018)

Article

Recurrent targets of aberrant somatic hypermutation in lymphoma

Alireza Hadj Khodabakhshi et al.

Oncotarget (2015)