☆ 4.6 Article

Modeling Colorectal Cancer Progression Reveals Niche-Dependent Clonal Selection

CANCERS (2022)

Related references

Note: Only part of the references are listed.

Letter Oncology

Elimination of fluorescent protein immunogenicity permits modeling of metastasis in immune-competent settings

Candice A. Grzelak et al.

CANCER CELL (2022)

Add to Collection

Review Oncology

Intestinal stem cell dynamics in homeostasis and cancer

Rana Ramadan et al.

Summary: The relationship between intestinal stem cells and colorectal cancer has been intensively studied, uncovering the dynamics of stem cells in homeostasis and cancer initiation. The microenvironment plays a crucial role in regulating stem cell fate and functionality, and imbalances in signaling between the niche and stem cells can disturb homeostasis and promote cancer development.

TRENDS IN CANCER (2022)

Add to Collection

Article Gastroenterology & Hepatology

Strong Reduction of Colorectal Cancer Incidence and Mortality After Screening Colonoscopy: Prospective Cohort Study From Germany

Feng Guo et al.

Summary: In this large prospective cohort study from Germany, screening colonoscopy was associated with a strong reduction in colorectal cancer (CRC) incidence and mortality.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2021)

Add to Collection

Article Genetics & Heredity

The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer

Arafath K. Najumudeen et al.

Summary: Colorectal tumors with mutated KRAS and APC rely on the amino acid transporter SLC7A5 for tumorigenesis and enhanced protein synthesis. Targeting SLC7A5 could be an attractive approach for therapy-resistant KRAS-mutant colorectal cancer, as it plays a critical role in maintaining intracellular amino acid levels and supporting proliferation.

NATURE GENETICS (2021)

Add to Collection

Article Oncology

MNK Inhibition Sensitizes KRAS-Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression

John R. P. Knight et al.

Summary: KRAS-mutant colorectal cancers exhibit resistance to therapeutics, but targeting the mTORC1 and MNK pathways can sensitize them to rapalogs. This approach has shown effectiveness in mouse models and human organoids, offering a potential strategy for patients with elevated c-MYC expression.

CANCER DISCOVERY (2021)

Add to Collection

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Add to Collection

Review Cell Biology

Advances in colon cancer research: in vitro and animal models

Tamsin R. M. Lannagan et al.

Summary: Researchers have made significant advancements in modelling human colon cancer by utilizing genetics, stem cell biology, tumour microenvironment, and immunology. Recent major progress includes the use of patient derived organoids, molecular stratification of tumors, mouse models of metastatic disease, and transplant models to de-risk clinical trials.

CURRENT OPINION IN GENETICS & DEVELOPMENT (2021)

Add to Collection

Article Oncology

Differential Effects of Trp53 Alterations in Murine Colorectal Cancer

Alexander M. Betzler et al.

Summary: The new mouse model accurately mimics the biology of human colorectal cancer and provides insights into treatment responses of different gene mutations.

CANCERS (2021)

Add to Collection

Article Oncology

Actual survival after resection of primary colorectal cancer: results from a prospective multicenter study

Inge van den Berg et al.

Summary: In this study, 754 patients with stage I-III colorectal cancer were analyzed, showing a cure rate of 65%. Patients with stage I disease and T1- and N0-tumors had the highest probability of cure, while those with T4-tumors or N2-tumors had the lowest. Older patients exhibited early excess mortality, and a similar trend was seen for stage III disease, poor tumor grade, postoperative complications, sarcopenia, and R1 resections.

WORLD JOURNAL OF SURGICAL ONCOLOGY (2021)

Add to Collection

Review Oncology

Rational Treatment of Metastatic Colorectal Cancer: A Reverse Tale of Men, Mice, and Culture Dishes

Marco Avolio et al.

Summary: Patient-derived models have played a crucial role in advancing the understanding of colorectal cancer biology, leading to the discovery of new therapeutic targets and mechanisms of drug resistance. These models have also influenced clinical decision-making by providing valuable insights into disease mechanisms and treatment responses.

CANCER DISCOVERY (2021)

Add to Collection

Article Oncology

Copy number and transcriptome alterations associated with metastatic lesion response to treatment in colorectal cancer

Karen Gambaro et al.

Summary: A study on genomic plasticity in liver metastatic samples of colorectal cancer revealed an increased frequency of specific CN in metastatic lesions after first-line treatment. Comparison of CNA profiles in lesions with different treatment responses showed focal genomic divergences in post-treatment resistant lesions but not in responder lesions. Examining metastatic lesions is crucial as 15 out of 18 independently validated CNA regions associated with progression-free survival were only identified in metastatic lesions, not in primary tumors.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

Add to Collection

Review Oncology

Microbiome and cancer

Nyssa Cullin et al.

Summary: The human microbiome is a complex community that interacts symbiotically with the host across various body sites, impacting physiological processes and disease conditions. While the influence of microbiome communities on cancer development and treatment responsiveness is still being unraveled, understanding these interactions may lead to advancements in precision cancer therapeutics.

CANCER CELL (2021)

Add to Collection

Article Biochemistry & Molecular Biology

BCL-XL is crucial for progression through the adenoma-to-carcinoma sequence of colorectal cancer

Prashanthi Ramesh et al.

Summary: The study suggests a shift in antiapoptotic protein reliance in the progression of colorectal cancer, with BCL-2 being essential during ISC transformation and BCL-XL playing a crucial role in stem cell survival from adenoma to carcinoma. Targeting BCL-XL may enhance the efficacy of chemotherapy in CRC management.

CELL DEATH AND DIFFERENTIATION (2021)

Add to Collection

Article Multidisciplinary Sciences

Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis

Joshua D. G. Leach et al.

Summary: Right-sided colorectal cancer (rCRC) has a distinct mutational spectrum compared to the left-sided counterpart. Researchers developed a mouse model of rCRC that mirrors human BRAF-mutant rCRC and demonstrated that loss of TGF beta-receptor signaling and inflammation induce the development of colonic tumors with a foetal-like phenotype.

NATURE COMMUNICATIONS (2021)

Add to Collection

Article Multidisciplinary Sciences

The site of breast cancer metastases dictates their clonal composition and reversible transcriptomic profile

Jean Berthelet et al.

Summary: The study optimized the use of optical barcoding to visualize and characterize cancer subclones, revealing that lung metastases were highly polyclonal while liver metastases were not. The transcriptome of the subclones varied according to their metastatic niche, indicating that the heterogeneity observed in metastases is largely dictated by the tumor microenvironment.

SCIENCE ADVANCES (2021)

Add to Collection

Article Oncology

Low neoantigen expression and poor T-cell priming underlie early immune escape in colorectal cancer

Peter M. K. Westcott et al.

Summary: The study reveals that despite low TMB, tumors from patients with microsatellite stable colorectal cancer still express predicted neoantigens, although at lower levels compared to those in colorectal cancer with microsatellite instability. Low expression of neoantigens may lead to immediate T-cell dysfunction, but it can be controlled by restoring priming in tumors with low neoantigen expression.

NATURE CANCER (2021)

Add to Collection

Article Biochemical Research Methods

Mouse model of colorectal cancer: Orthotopic co-implantation of tumor and stroma cells in cecum and rectum

Hiroaki Kasashima et al.

Summary: The study introduces a protocol for the orthotopic co-implantation of tumoral and stromal cells into the cecum and rectum to investigate the crosstalk between tumor and its microenvironment, recapitulating metastases observed in human CRC to lymph nodes, liver, and lungs. For detailed information on the protocol's use and execution, please refer to Kasashima et al. (2020).

STAR PROTOCOLS (2021)

Add to Collection

Review Gastroenterology & Hepatology

Therapeutic Targeting of the Colorectal Tumor Stroma

Wolf H. Fridman et al.

GASTROENTEROLOGY (2020)

Add to Collection

Article Oncology

Colorectal cancer statistics, 2020

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2020)

Add to Collection

Article Cell & Tissue Engineering

Zonation of Ribosomal DNA Transcription Defines a Stem Cell Hierarchy in Colorectal Cancer

Clara Morral et al.

CELL STEM CELL (2020)

Add to Collection

Article Genetics & Heredity

Multi-cancer analysis of clonality and the timing of systemic spread in paired primary tumors and metastases

Zheng Hu et al.

NATURE GENETICS (2020)

Add to Collection

Article Genetics & Heredity

Lymph node metastases develop through a wider evolutionary bottleneck than distant metastases

Johannes G. Reiter et al.

NATURE GENETICS (2020)

Add to Collection

Article Oncology

Reduction of Liver Metastasis Stiffness Improves Response to Bevacizumab in Metastatic Colorectal Cancer

Ying Shen et al.

CANCER CELL (2020)

Add to Collection

Article Oncology

Establishment of an Endoscopy-Guided Minimally Invasive Orthotopic Mouse Model of Colorectal Cancer

Chen Chen et al.

CANCERS (2020)

Add to Collection

Article Multidisciplinary Sciences

Spatiotemporal regulation of clonogenicity in colorectal cancer xenografts

Maartje van der Heijden et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Add to Collection

Article Multidisciplinary Sciences

Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer

David M. Gay et al.

NATURE COMMUNICATIONS (2019)

Add to Collection

Article Genetics & Heredity

Quantitative evidence for early metastatic seeding in colorectal cancer

Zheng Hu et al.

NATURE GENETICS (2019)

Add to Collection

Article Oncology

Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis

Rene Jackstadt et al.

CANCER CELL (2019)

Add to Collection

Article Biochemistry & Molecular Biology

A rectal cancer organoid platform to study individual responses to chemoradiation

Karuna Ganesh et al.

NATURE MEDICINE (2019)

Add to Collection

Review Oncology

Tumour heterogeneity and resistance to cancer therapies

Ibiayi Dagogo-Jack et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

Add to Collection

Article Oncology

Clinical Sequencing Defines the Genomic Landscape of Metastatic Colorectal Cancer

Rona Yaeger et al.

CANCER CELL (2018)

Add to Collection

Article Cell & Tissue Engineering

Reconstruction of the Human Colon Epithelium In Vivo

Shinya Sugimoto et al.

CELL STEM CELL (2018)

Add to Collection

Article Cell & Tissue Engineering

YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration

Shiro Yui et al.

CELL STEM CELL (2018)

Add to Collection

Article Cell Biology

Multicolour lineage tracing reveals clonal dynamics of squamous carcinoma evolution from initiation to metastasis

Melissa Q. Reeves et al.

NATURE CELL BIOLOGY (2018)

Add to Collection

Article Biochemical Research Methods

Colonoscopy-based colorectal cancer modeling in mice with CRISPR-Cas9 genome editing and organoid transplantation

Jatin Roper et al.

NATURE PROTOCOLS (2018)

Add to Collection

Article Oncology

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Freddie Bray et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Evolution of Metastases in Space and Time under Immune Selection

Mihaela Angelova et al.

CELL (2018)

Add to Collection

Review Oncology

Organoids in cancer research

Jarno Drost et al.

NATURE REVIEWS CANCER (2018)

Add to Collection

Article Biotechnology & Applied Microbiology

Optical Barcoding for Single-Clone Tracking to Study Tumor Heterogeneity

Malte Mohme et al.

MOLECULAR THERAPY (2017)

Add to Collection

Article Multidisciplinary Sciences

A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer

Felipe de Sousa e Melo et al.

NATURE (2017)

Add to Collection

Article Multidisciplinary Sciences

Visualization and targeting of LGR5+ human colon cancer stem cells

Mariko Shimokawa et al.

NATURE (2017)

Add to Collection

Article Biotechnology & Applied Microbiology

In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis

Jatin Roper et al.

NATURE BIOTECHNOLOGY (2017)

Add to Collection

Article Biotechnology & Applied Microbiology

Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer

Kevin P. O'Rourke et al.

NATURE BIOTECHNOLOGY (2017)

Add to Collection

Article Multidisciplinary Sciences

Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids

Arianna Fumagalli et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Add to Collection

Article Multidisciplinary Sciences

Cancer-cell intrinsic gene expression signatures overcome intratumoural heterogeneity bias in colorectal cancer patient classification

Philip D. Dunne et al.

NATURE COMMUNICATIONS (2017)

Add to Collection

Article Multidisciplinary Sciences

Selective analysis of cancer-cell intrinsic transcriptional traits defines novel clinically relevant subtypes of colorectal cancer

Claudio Isella et al.

NATURE COMMUNICATIONS (2017)

Add to Collection

Article Multidisciplinary Sciences

DNA copy number changes define spatial patterns of heterogeneity in colorectal cancer

Soulafa Mamlouk et al.

NATURE COMMUNICATIONS (2017)

Add to Collection

Article Multidisciplinary Sciences

Multicolor lineage tracing reveals clonal architecture and dynamics in colon cancer

Sebastian Lamprecht et al.

NATURE COMMUNICATIONS (2017)

Add to Collection

Review Oncology

Mouse models of intestinal cancer

Rene Jackstadt et al.

JOURNAL OF PATHOLOGY (2016)

Add to Collection

Article Cell & Tissue Engineering

A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis

Masayuki Fujii et al.

CELL STEM CELL (2016)

Add to Collection

Article Biochemistry & Molecular Biology

Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients

Giulia Siravegna et al.

NATURE MEDICINE (2015)

Add to Collection

Article Biochemistry & Molecular Biology

The consensus molecular subtypes of colorectal cancer

Justin Guinney et al.

NATURE MEDICINE (2015)

Add to Collection

Article Oncology

Pancreatic Cancer Metastases Harbor Evidence of Polyclonality

Ravikanth Maddipati et al.

CANCER DISCOVERY (2015)

Add to Collection

Article Cell Biology

Small intestinal stem cell identity is maintained with functional Paneth cells in heterotopically grafted epithelium onto the colon

Masayoshi Fukuda et al.

GENES & DEVELOPMENT (2014)

Add to Collection

Article Multidisciplinary Sciences

Lymph node-independent liver metastasis in a model of metastatic colorectal cancer

Ida B. Enquist et al.

NATURE COMMUNICATIONS (2014)

Add to Collection

Article Immunology

AP4 is a mediator of epithelial-mesenchymal transition and metastasis in colorectal cancer

Rene Jackstadt et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2013)

Add to Collection

Article Biochemistry & Molecular Biology

Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell

Shiro Yui et al.

NATURE MEDICINE (2012)

Add to Collection

Article Multidisciplinary Sciences

Utilization of Murine Colonoscopy for Orthotopic Implantation of Colorectal Cancer

Ehud Zigmond et al.

PLOS ONE (2011)

Add to Collection

Article Oncology

Actual 10-year survival after resection of colorectal liver Metastases defines cure

James S. Tomlinson et al.

JOURNAL OF CLINICAL ONCOLOGY (2007)

Add to Collection

Article Genetics & Heredity

Adenomatous polyposis coli (APC) is required for normal development of skin and thymus

Mari Kuraguchi et al.

PLOS GENETICS (2006)

Add to Collection

Article Developmental Biology

Tissue-specific and inducible Cre-mediated recombination in the gut epithelium

F El Marjou et al.

GENESIS (2004)

Add to Collection

© Peeref 2019-2024. All rights reserved.