4.6 Review

Chimeric Antigen Receptor Immunotherapy for Solid Tumors: Choosing the Right Ingredients for the Perfect Recipe

Related references

Note: Only part of the references are listed.
Review Hematology

Promise and pitfalls of allogeneic chimeric antigen receptor therapy in plasma cell and lymphoid malignancies

Binod Dhakal et al.

Summary: CAR T-cell therapy shows promise in haematological malignancies, but the complexity of autologous CAR T-cell therapy poses logistical challenges. Allogeneic effector cells offer potential solutions, but challenges such as alloreactivity need to be addressed for their widespread use.

BRITISH JOURNAL OF HAEMATOLOGY (2022)

Editorial Material Medicine, Research & Experimental

Point-of-care cell therapy manufacturing; it's not for everyone

David F. Stroncek et al.

Summary: The use of cellular therapies for various diseases is rapidly increasing, leading to the development of reagents and automated instruments for production. There is a growing interest in decentralized manufacturing for clinical trials, but this requires harmonization of processes and quality control between multiple sites.

JOURNAL OF TRANSLATIONAL MEDICINE (2022)

Article Oncology

Long-term activity of tandem CD19/CD20 CAR therapy in refractory/relapsed B-cell lymphoma: a single-arm, phase 1-2 trial

Yajing Zhang et al.

Summary: A clinical trial of CAR T cell therapy for recurrent/refractory non-Hodgkin lymphoma showed a high overall response rate and progression-free survival, with manageable side effects such as cytokine release syndrome and CAR T cell-related encephalopathy syndrome.

LEUKEMIA (2022)

Article Biochemistry & Molecular Biology

PSMA-targeting TGFβ-insensitive armored CAR T cells in metastatic castration-resistant prostate cancer: a phase 1 trial

Vivek Narayan et al.

Summary: CAR T cells show promising efficacy in hematologic malignancies, but face challenges in solid tumors due to the immunosuppressive tumor microenvironment. This study reports results from a phase 1 trial using engineered CAR T cells resistant to TGF-beta signaling in castration-resistant prostate cancer patients, showing both efficacy and dose-dependent toxicity. Future studies should explore multipronged approaches to improve outcomes in this setting.

NATURE MEDICINE (2022)

Review Oncology

Systematic Review of Available CAR-T Cell Trials around the World

Luciana Rodrigues Carvalho Barros et al.

Summary: This systematic review provides a worldwide overview of clinical trials evaluating new CAR-T cell therapies against different types of cancers, detailing the latest trends in CAR-T cell development. It predicts the potential approval of CAR-T cell therapies against hematological and solid tumor malignancies in the near future. China and the USA are leading in clinical studies involving CAR-T, with CD19 and BCMA being the most targeted hematological antigens.

CANCERS (2022)

Article Pharmacology & Pharmacy

Locoregional delivery of CAR-T cells in the clinic

Sharon M. Sagnella et al.

Summary: Cellular therapies utilizing T cells expressing CARs have been successful in hematological malignancies, but not in solid tumors. Locoregional delivery of CAR-T cells is an approach to overcome challenges in solid tumors, and it has been shown to be safe and feasible in clinical trials.

PHARMACOLOGICAL RESEARCH (2022)

Review Immunology

Gamma Delta T-Cell Based Cancer Immunotherapy: Past-Present-Future

Jose Saura-Esteller et al.

Summary: Gamma delta T-cells can recognize and kill transformed cells independently of HLA-antigen presentation, making them a promising effector cell compartment for cancer immunotherapy. Current research is focused on the V delta 1 and V delta 2 T-cell subtypes, with V delta 1 enriched in tissues and V delta 2 enriched in circulation.

FRONTIERS IN IMMUNOLOGY (2022)

Review Immunology

Review: Sustainable Clinical Development of CAR-T Cells - Switching From Viral Transduction Towards CRISPR-Cas Gene Editing

Dimitrios L. Wagner et al.

Summary: Gene editing technologies offer exciting possibilities for synthetic biology in CAR-T cell engineering and production. Precise insertion of CARs into the genome and combinatorial gene knock-ins and knock-outs can improve therapeutic efficacy of T cells. These technologies also have the potential to increase production efficiency and reduce costs.

FRONTIERS IN IMMUNOLOGY (2022)

Article Medicine, Research & Experimental

CAR T cell manufacturing from naive/stem memory T lymphocytes enhances antitumor responses while curtailing cytokine release syndrome

Silvia Arcangeli et al.

Summary: This study investigated the efficacy and safety profiles of CAR T cell products generated from preselected naive/stem memory T cells (TN/SCM). The results showed that CAR TN/SCM cells exhibited stronger antitumor activity and were able to prevent leukemia relapse. Furthermore, CAR TN/SCM cells had a lower risk of inducing severe cytokine release syndrome, indicating a higher therapeutic index.

JOURNAL OF CLINICAL INVESTIGATION (2022)

Review Cell Biology

Harnessing the chemokine system to home CAR-T cells into solid tumors

Jade Foeng et al.

Summary: CAR-T cell therapy has shown success in treating hematological malignancies, but faces challenges when applied to solid cancers. By utilizing the chemokine system, CAR-T cells can be guided into tumors, overcoming this obstacle.

CELL REPORTS MEDICINE (2022)

Review Biotechnology & Applied Microbiology

Optimization of electroporation and other non-viral gene delivery strategies for T cells

Emily Harris et al.

Summary: CAR-T therapy uses retroviruses to deliver CAR genes to a patient's T cells, effectively treating cancers like NHL and ALL. However, the current manufacturing process of CAR-T cells has drawbacks, prompting the search for alternative non-viral gene delivery methods.

BIOTECHNOLOGY PROGRESS (2021)

Review Biotechnology & Applied Microbiology

Choosing the Right Tool for Genetic Engineering: Clinical Lessons from Chimeric Antigen Receptor-T Cells

Melita Irving et al.

Summary: CAR-T cell therapy shows great potential for treating B cell malignancies, but translating it to other tumor types remains a challenge. Research is ongoing to develop more sophisticated methods and tools for engineering T cells to overcome limitations of traditional viral vectors.

HUMAN GENE THERAPY (2021)

Review Genetics & Heredity

Genetic engineering of T cells for immunotherapy

Gavin I. Ellis et al.

Summary: Genetically engineered T cell immunotherapies have shown remarkable success in treating B cell acute lymphoblastic leukemia by using a patient's own T cells to target cancer cells. However, more complex levels of genetic regulation will be necessary to ensure safety and efficacy in future therapies.

NATURE REVIEWS GENETICS (2021)

Article Medicine, General & Internal

Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma

Nikhil C. Munshi et al.

Summary: The phase 2 study confirmed the efficacy and safety of ide-cel in patients with relapsed and refractory myeloma, with a majority of patients achieving responses and 26% achieving MRD-negative status. Despite the high response rate, almost all patients experienced grade 3 or 4 toxic effects, including hematologic toxic effects and cytokine release syndrome.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Cell Biology

Combining a CAR and a chimeric costimulatory receptor enhances T cell sensitivity to low antigen density and promotes persistence

Afroditi Katsarou et al.

Summary: The study demonstrates that dual targeting and costimulation through a combination of CAR and CCR can enhance the cytotoxicity and persistence of CAR T cells, thus preventing relapses of tumor clones with low target antigen density.

SCIENCE TRANSLATIONAL MEDICINE (2021)

Article Medicine, Research & Experimental

Promoter usage regulating the surface density of CAR molecules may modulate the kinetics of CAR-T cells in vivo

Jin-Yuan Ho et al.

Summary: The study showed that the use of the MND promoter can increase the transduction rate of CAR-T cells while reducing CAR surface density, leading to prolonged antileukemia activity. In a clinical trial, subjects infused with MND-driven CAR-T cells experienced mild fever, but most of them achieved complete remission after one month of evaluation.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2021)

Review Oncology

Promises and challenges of adoptive T-cell therapies for solid tumours

Matteo Morotti et al.

Summary: Cancer remains a leading cause of death globally, with metastatic disease posing challenges even with advancements in targeted therapies and immunotherapies. Adoptive T-cell therapy has shown promise in providing durable responses and potential cures for cancer patients. Advancements in genomics, immunology, and cell manufacturing are bringing personalized therapies for cancer patients closer to reality, challenging traditional standards of care and offering opportunities for a paradigm shift in cancer therapy.

BRITISH JOURNAL OF CANCER (2021)

Review Pharmacology & Pharmacy

Immunotherapy to get on point with base editing

Jennifer A. Harbottle

Summary: Engineered immune cell therapy is revolutionizing cancer treatment, with FDA-approved CAR-T cell products paving the way for personalized therapies. However, multiple genetic edits are needed for refractory tumors, and off-target effects of CRISPR-Cas9 may hinder its clinical application. Novel base editing technologies offer a promising and safer alternative for enhancing allogeneic engineered immunotherapies targeting solid tumors and other complex diseases.

DRUG DISCOVERY TODAY (2021)

Review Immunology

Engineered CAR-Macrophages as Adoptive Immunotherapies for Solid Tumors

Christopher Sloas et al.

Summary: Cellular immunotherapies, particularly using macrophages as adoptive cell therapies, show promise in treating solid tumors. Engineered CAR macrophages (CAR-M) have the potential for effective treatment against solid malignancies, highlighting the importance of manipulating immune cell function in cancer therapy.

FRONTIERS IN IMMUNOLOGY (2021)

Article Biochemistry & Molecular Biology

CARAMBA: a first-in-human clinical trial with SLAMF7 CAR-T cells prepared by virus-free Sleeping Beauty gene transfer to treat multiple myeloma

Sabrina Prommersberger et al.

Summary: Clinical development of CAR-T-cell therapy has been advanced by synthetic biology, genetic engineering, and clinical-grade manufacturing, with the goal of providing safe, effective, and economically sustainable treatment. The CARAMBA project aims to demonstrate virus-free CAR gene transfer using advanced SB transposon technology, potentially improving vector procurement, CAR-T manufacturing, and distribution. The project focuses on utilizing SB-based CAR-T cells targeting the SLAMF7 antigen in multiple myeloma, with promising preclinical results indicating potent anti-myeloma activity.

GENE THERAPY (2021)

Article Oncology

Off-the-shelf Vδ1 gamma delta T cells engineered with glypican-3 (GPC-3)-specific chimeric antigen receptor (CAR) and soluble IL-15 display robust antitumor efficacy against hepatocellular carcinoma

Amani Makkouk et al.

Summary: The use of engineered V delta 1 CAR T cells targeting GPC-3 in HCC shows promising efficacy and can overcome challenges faced by traditional T cell therapies in solid tumors.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Article Oncology

4-1BB and optimized CD28 co-stimulation enhances function of human mono-specific and bi-specific third-generation CAR T cells

Emiliano Roselli et al.

Summary: The study demonstrates that combining 4-1BB with an optimized form of CD28 for co-stimulation is an effective way to enhance CAR T cell function. Both mono-specific and bi-specific versions of this design show improved expansion, persistence, and resistance to exhaustion in vitro and in vivo.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Review Oncology

The Current Landscape of NKT Cell Immunotherapy and the Hills Ahead

Adam Nelson et al.

Summary: NKT cells are a specialized subset of lipid-reactive T lymphocytes that play direct and indirect roles in immunosurveillance and anti-tumor immunity. Preclinical studies have shown that NKT cell activation via delivery of exogenous glycolipids elicits a significant anti-tumor immune response. This review also examines challenges and future directions for improving the therapy.

CANCERS (2021)

Review Biotechnology & Applied Microbiology

Navigating CAR-T cells through the solid-tumour microenvironment

Andrew J. Hou et al.

Summary: CAR-T cells have limited efficacy in treating solid tumors, but various engineering strategies can overcome the obstacles posed by the tumor microenvironment, producing next-generation T cells with enhanced specificity and sustained effector function.

NATURE REVIEWS DRUG DISCOVERY (2021)

Article Immunology

Phase I study of CAR-T cells with PD-1 and TCR disruption in mesothelin-positive solid tumors

Zhenguang Wang et al.

Summary: The study showed the preliminary feasibility and safety of CRISPR-engineered CAR-T cells with PD-1 disruption in a dose-escalation study with 15 patients, demonstrating no dose-limiting toxicity or unexpected adverse events. Furthermore, it indicated the importance of natural TCR in the persistence of CAR-T cells when treating solid tumors, as TCR-positive CAR-T cells were predominantly detected in effusion or peripheral blood after infusion.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

Article Medicine, General & Internal

Ciltacabtagene autoleucel, a B-cell maturation antigendirected chimeric antigen receptor T-cell therapy in patients with relapsed or refractory multiple myeloma (CARTITUDE-1): a phase 1b/2 open-label study

Jesus G. Berdeja et al.

Summary: The study aimed to evaluate the safety and clinical activity of cilta-cel in patients with relapsed or refractory multiple myeloma, and the results showed that cilta-cel treatment achieved good efficacy and safety with short treatment duration, deep response, and long duration of response.

LANCET (2021)

Review Oncology

A comparison of chimeric antigen receptors containing CD28 versus 4-1BB costimulatory domains

Kathryn M. Cappell et al.

Summary: CAR T cell therapies targeting haematological malignancies show promising efficacy, with CD28- and 4-1BB-derived costimulatory domains demonstrating potentially different cellular and clinical effects. Further research is needed to compare their effectiveness and toxicity profiles.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

Article Oncology

A Phase I Trial of Regional Mesothelin-Targeted CAR T-cell Therapy in Patients with Malignant Pleural Disease, in Combination with the Anti-PD-1 Agent Pembrolizumab

Prasad S. Adusumilli et al.

Summary: Regional delivery of mesothelin-targeted CAR T-cell therapy followed by pembrolizumab administration is safe, feasible, and demonstrates evidence of antitumor efficacy in patients with malignant pleural diseases. Our data support the investigation of combination immunotherapy with CAR T cells and PD-1 blockade agents in solid tumors.

CANCER DISCOVERY (2021)

Article Oncology

Conditioned CAR-T cells by hypoxia-inducible transcription amplification (HiTA) system significantly enhances systemic safety and retains antitumor efficacy

Huan He et al.

Summary: The study demonstrates that hypoxia-inducible HiTA-CAR-T cells exhibit high tumor cytotoxicity and activity while showing low on-target toxicity to normal tissues. The HiTA system represents a significant improvement in transgene expression, providing a promising approach for designing CAR-T cells targeting various tumor antigens.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Review Oncology

Scalable Manufacturing of CAR T Cells for Cancer Immunotherapy

Mohamed Abou-el-Enein et al.

Summary: This review discusses the current status of commercially available CAR T cell therapies for hematologic malignancies and the shift towards Good Manufacturing Practice-compliant closed and automated systems in the industry. It also highlights the emerging technologic advances in CART cell manufacturing and the challenges in scaling production for clinical use. The review emphasizes the significance of closed and automated production platforms to meet the increasing demand for CAR T cell cancer therapy.

BLOOD CANCER DISCOVERY (2021)

Review Health Care Sciences & Services

Tracking the CAR-T Revolution: Analysis of Clinical Trials of CAR-T and TCR-T Therapies for the Treatment of Cancer (1997-2020)

Nikola A. Ivica et al.

Summary: CAR-T/TCR-T cellular immunotherapies have shown remarkable success in treating refractory B-cell malignancies. The increase in clinical trials is driven by the development of different CAR-T products, with China and the US being major innovators in the field. This industry exhibits a robust response to competitor products, with the term "bioparallels" coined to describe similar therapeutic approaches.

HEALTHCARE (2021)

Article Cell Biology

Hypoxia-sensing CAR T cells provide safety and efficacy in treating solid tumors

Paris Kosti et al.

Summary: In this study, a new CAR T cell system utilizing hypoxia-sensing technology for selective expression of pan-ErbB targeted CAR within solid tumors was presented. The approach demonstrated anti-tumor efficacy without off-tumor toxicity, showing potential for expansion of CAR T cell target repertoire for treating solid malignancies.

CELL REPORTS MEDICINE (2021)

Article Immunology

Memory stem T cells modified with a redesigned CD30-chimeric antigen receptor show an enhanced antitumor effect in Hodgkin lymphoma

Carmen Alvarez-Fernandez et al.

Summary: A novel CD30-CAR T cell therapy using T-SCM has shown improved efficacy in eradicating Hodgkin lymphoma in preclinical experiments, with the T cells exhibiting high persistence and enhanced antitumor activity compared to traditional CAR T cells.

CLINICAL & TRANSLATIONAL IMMUNOLOGY (2021)

Review Biotechnology & Applied Microbiology

Translating gammadelta (gamma delta) T cells and their receptors into cancer cell therapies

Zsolt Sebestyen et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

Review Biotechnology & Applied Microbiology

'Off-the-shelf' allogeneic CAR T cells: development and challenges

S. Depil et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

Article Medicine, General & Internal

Use of CAR-Transduced Natural Killer Cells in CD19-Positive Lymphoid Tumors

Enli Liu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Review Multidisciplinary Sciences

Chimeric antigen receptor signaling: Functional consequences and design implications

S. E. Lindner et al.

SCIENCE ADVANCES (2020)

Article Biotechnology & Applied Microbiology

Human chimeric antigen receptor macrophages for cancer immunotherapy

Michael Klichinsky et al.

NATURE BIOTECHNOLOGY (2020)

Article Medicine, General & Internal

KTE-X19 CAR T-Cell Therapy in Relapsed or Refractory Mantle-Cell Lymphoma

Michael Wang et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Review Immunology

CAR-T Cells Hit the Tumor Microenvironment: Strategies to Overcome Tumor Escape

Alba Rodriguez-Garcia et al.

FRONTIERS IN IMMUNOLOGY (2020)

Article Medicine, Research & Experimental

A rational mouse model to detect on-target, off-tumor CAR T cell toxicity

Mauro Castellarin et al.

JCI INSIGHT (2020)

Article Medicine, Research & Experimental

Sleeping Beauty engineered CAR T cells achieve antileukemic activity without severe toxicities

Chiara F. Magnani et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Article Biochemistry & Molecular Biology

Anti-GD2 CAR-NKT cells in patients with relapsed or refractory neuroblastoma: an interim analysis

Andras Heczey et al.

NATURE MEDICINE (2020)

Review Oncology

Immunosenescence: a key player in cancer development

Jingyao Lian et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

Article Oncology

Collagen density regulates the activity of tumor-infiltrating T cells

Dorota E. Kuczek et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

Review Cell Biology

The next generation of CRISPR-Cas technologies and applications

Adrian Pickar-Oliver et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Article Multidisciplinary Sciences

Engineered triple inhibitory receptor resistance improves anti-tumor CAR-T cell performance via CD56

Fan Zou et al.

NATURE COMMUNICATIONS (2019)

Article Biotechnology & Applied Microbiology

IL-7 and CCL19 expression in CAR-T cells improves immune cell infiltration and CAR-T cell survival in the tumor

Keishi Adachi et al.

NATURE BIOTECHNOLOGY (2018)

Article Medicine, General & Internal

Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia

S. L. Maude et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Review Chemistry, Multidisciplinary

Chimeric Antigen Receptor T-Cells (CAR T-Cells) for Cancer Immunotherapy - Moving Target for Industry?

Paula Salmikangas et al.

PHARMACEUTICAL RESEARCH (2018)

Article Biology

Chimeric antigen receptors that trigger phagocytosis

Meghan A. Morrissey et al.

ELIFE (2018)

Article Biotechnology & Applied Microbiology

Targeted delivery of a PD-1-blocking scFv by CAR-T cells enhances anti-tumor efficacy in vivo

Sarwish Rafiq et al.

NATURE BIOTECHNOLOGY (2018)

Review Oncology

Tumor Antigen Escape from CAR T-cell Therapy

Robbie G. Majzner et al.

CANCER DISCOVERY (2018)

Article Biotechnology & Applied Microbiology

Phase I Escalating-Dose Trial of CAR-T Therapy Targeting CEA+ Metastatic Colorectal Cancers

Chengcheng Zhang et al.

MOLECULAR THERAPY (2017)

Article Biotechnology & Applied Microbiology

Balance of Anti-CD123 Chimeric Antigen Receptor Binding Affinity and Density for the Targeting of Acute Myeloid Leukemia

Silvia Arcangeli et al.

MOLECULAR THERAPY (2017)

Article Biotechnology & Applied Microbiology

CAR T Cells Administered in Combination with Lymphodepletion and PD-1 Inhibition to Patients with Neuroblastoma

Andras Heczey et al.

MOLECULAR THERAPY (2017)

Review Biotechnology & Applied Microbiology

Chimeric Antigen Receptors: A Cell and Gene Therapy Perspective

Isabelle Riviere et al.

MOLECULAR THERAPY (2017)

Review Biotechnology & Applied Microbiology

Engineering Natural Killer Cells for Cancer Immunotherapy

Katayoun Rezvani et al.

MOLECULAR THERAPY (2017)

Article Multidisciplinary Sciences

Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection

Justin Eyquem et al.

NATURE (2017)

Article Medicine, General & Internal

Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma

S. S. Neelapu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Cell Biology

Molecular remission of infant B-ALL after infusion of universal TALEN gene-edited CAR T cells

Waseem Qasim et al.

SCIENCE TRANSLATIONAL MEDICINE (2017)

Article Multidisciplinary Sciences

An oxygen sensitive self-decision making engineered CAR T-cell

Alexandre Juillerat et al.

SCIENTIFIC REPORTS (2017)

Article Medicine, Research & Experimental

Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-mediated inhibition

Leonid Cherkassky et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Article Medicine, Research & Experimental

CD62L+ NKT cells have prolonged persistence and antitumor activity in vivo

Gengwen Tian et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Article Medicine, Research & Experimental

Phase I trials using Sleeping Beauty to generate CD19-specific CAR T cells

Partow Kebriaei et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Article Medicine, General & Internal

Regression of Glioblastoma after Chimeric Antigen Receptor T-Cell Therapy

Christine E. Brown et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Oncology

Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy

Suzanne L. Topalian et al.

CANCER CELL (2015)

Review Immunology

Targeting the tumor vasculature to enhance T cell activity

Evripidis Lanitis et al.

CURRENT OPINION IN IMMUNOLOGY (2015)

Article Biochemistry & Molecular Biology

Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes

Ignazio Caruana et al.

NATURE MEDICINE (2015)

Article Biochemistry & Molecular Biology

4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors

Adrienne H. Long et al.

NATURE MEDICINE (2015)

Review Biotechnology & Applied Microbiology

The pharmacology of second-generation chimeric antigen receptors

Sjoukje J. C. van der Stegen et al.

NATURE REVIEWS DRUG DISCOVERY (2015)

Article Oncology

Immune Escape Mechanisms as a Guide for Cancer Immunotherapy

Gregory L. Beatty et al.

CLINICAL CANCER RESEARCH (2015)

Review Immunology

Molecular mechanisms that influence the macrophage M1-M2 polarization balance

Nan Wang et al.

FRONTIERS IN IMMUNOLOGY (2014)

Article Biotechnology & Applied Microbiology

Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells

Christopher C. Kloss et al.

NATURE BIOTECHNOLOGY (2013)

Review Immunology

Molecular mechanisms of T cell co-stimulation and co-inhibition

Lieping Chen et al.

NATURE REVIEWS IMMUNOLOGY (2013)

Article Multidisciplinary Sciences

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

Martin Jinek et al.

SCIENCE (2012)

Article Biochemistry & Molecular Biology

A human memory T cell subset with stem cell-like properties

Luca Gattinoni et al.

NATURE MEDICINE (2011)

Article Biochemistry & Molecular Biology

DNA Transposons: Nature and Applications in Genomics

Martin Munoz-Lopez et al.

CURRENT GENOMICS (2010)

Review Immunology

TNF family ligands define niches for T cell memory

Laurent Sabbagh et al.

TRENDS IN IMMUNOLOGY (2007)

Article Biotechnology & Applied Microbiology

Adoptive transfer of chimeric antigen receptor re-directed cytolytic T lymphocyte clones in patients with neuroblastoma

Julie R. Park et al.

MOLECULAR THERAPY (2007)

Article Oncology

A phase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancer

Michael H. Kershaw et al.

CLINICAL CANCER RESEARCH (2006)

Article Immunology

Natural killer T cells infiltrate neuroblastomas expressing the chemokine CCL2

LS Metelitsa et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2004)

Article Biotechnology & Applied Microbiology

Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCR zeta/CD28 receptor

J Maher et al.

NATURE BIOTECHNOLOGY (2002)

Article Biotechnology & Applied Microbiology

Systematic determination of the packaging limit of lentiviral vectors

M Kumar et al.

HUMAN GENE THERAPY (2001)