4.6 Article

Recurrent NOMO1 Gene Deletion Is a Potential Clinical Marker in Early-Onset Colorectal Cancer and Is Involved in the Regulation of Cell Migration

Related references

Note: Only part of the references are listed.
Article Gastroenterology & Hepatology

Deleting the β-catenin degradation domain in mouse hepatocytes drives hepatocellular carcinoma or hepatoblastoma-like tumor growth

Robin Loesch et al.

Summary: The study explored the relationship between the deletion of exon 3 in the CTNNBI gene and liver tumor development, and compared it with the mutation in exon 15 of the APC gene. The results showed that both mutation models could generate tumors similar to human liver cancer, providing a powerful preclinical model.

JOURNAL OF HEPATOLOGY (2022)

Article Cell Biology

A requirement for p120-catenin in the metastasis of invasive ductal breast cancer

Sarah J. Kurley et al.

Summary: The study shows that p120 plays a positive role in the tumor microenvironment and metastatic colonization of distant sites, while its downregulation in primary tumors indirectly enhances metastatic dissemination.

JOURNAL OF CELL SCIENCE (2021)

Article Gastroenterology & Hepatology

Risk factors and clinical characteristics of early-onset colorectal cancer vs. late-onset colorectal cancer: a case-case study

Milena Di Leo et al.

Summary: Early-onset colorectal cancer (eoCRC) patients have longer delay time from symptom onset to diagnosis compared to late-onset CRC (loCRC) patients. There are differences in sex, symptoms, family history, smoking habit, alcohol intake, and BMI between the two groups. Rectal localization is more common in eoCRC, and having a family history or hereditary cancer syndromes increases the risk of developing eoCRC.

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY (2021)

Review Gastroenterology & Hepatology

An Update on the Epidemiology, Molecular Characterization, Diagnosis, and Screening Strategies for Early-Onset Colorectal Cancer

Andrea N. Burnett-Hartman et al.

Summary: The rising incidence and mortality of early-onset colorectal cancer have prompted intense research into its epidemiology and characteristics. This review provides an update on early-onset CRC, focusing on epidemiology, molecular characterization, symptoms, and screening.

GASTROENTEROLOGY (2021)

Article Oncology

Rising incidence of early-onset colorectal cancer - a call to action

Naohiko Akimoto et al.

Summary: The global incidence of early-onset colorectal cancer is on the rise, potentially due to factors such as diet, obesity, lack of exercise, and antibiotic use. Early-onset CRC differs clinically, pathologically, and molecularly from later-onset CRC. Further research spanning childhood and young adulthood is necessary to enhance understanding and management of this disease.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Review Oncology

P120 and E-cadherin: Double-edged swords in tumor metastasis

Jan-Hendrik Venhuizen et al.

SEMINARS IN CANCER BIOLOGY (2020)

Editorial Material Gastroenterology & Hepatology

Distinct Molecular Phenotype of Sporadic Colorectal Cancers Among Young Patients Based on Multiomics Analysis

Andreana N. Holowatyj et al.

GASTROENTEROLOGY (2020)

Article Biochemistry & Molecular Biology

Establishment of a conditional Nomo1 mouse model by CRISPR/Cas9 technology

Ignacio Garcia-Tunon et al.

MOLECULAR BIOLOGY REPORTS (2020)

Article Oncology

Clinical and molecular characterization of early-onset colorectal cancer

Alexandra N. Willauer et al.

CANCER (2019)

Article Immunology

Lamin B1 loss promotes lung cancer development and metastasis by epigenetic derepression of RET

Yanhan Jia et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2019)

Article Biochemistry & Molecular Biology

WebGestalt 2019: gene set analysis toolkit with revamped UIs and APIs

Yuxing Liao et al.

NUCLEIC ACIDS RESEARCH (2019)

Review Oncology

Early-onset colorectal cancer in young individuals

Gianluca Mauri et al.

MOLECULAR ONCOLOGY (2019)

Article Medicine, Research & Experimental

Up-regulation of PCOLCE by TWIST1 promotes metastasis in Osteosarcoma

Shang Wang et al.

THERANOSTICS (2019)

Article Biochemical Research Methods

Online Parallel Accumulation Serial Fragmentation (PASEF) with a Novel Trapped on Mobility Mass Spectrometer

Florian Meier et al.

MOLECULAR & CELLULAR PROTEOMICS (2018)

Article Gastroenterology & Hepatology

Global patterns and trends in colorectal cancer incidence and mortality

Melina Arnold et al.

Article Oncology

NOMO-1 gene is deleted in early-onset colorectal cancer

Jose Perea et al.

ONCOTARGET (2017)

Review Biochemistry & Molecular Biology

p120-catenin in canonical Wnt signaling

Mireia Dunach et al.

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY (2017)

Review Oncology

Plasticity underlies tumor progression: role of Nodal signaling

Thomas M. Bodenstine et al.

CANCER AND METASTASIS REVIEWS (2016)

Article Oncology

P120ctn may participate in epithelial-mesenchymal transition in OSCC

C. Zhong et al.

INDIAN JOURNAL OF CANCER (2016)

Article Biochemical Research Methods

Plug-and-play analysis of the human phosphoproteome by targeted high-resolution mass spectrometry

Robert T. Lawrence et al.

NATURE METHODS (2016)

Article Oncology

P120ctn may participate in epithelial-mesenchymal transition in OSCC

C. Zhong et al.

INDIAN JOURNAL OF CANCER (2016)

Article Biochemistry & Molecular Biology

Dynamic regulation of the cancer stem cell compartment by Cripto-1 in colorectal cancer

F. Francescangeli et al.

CELL DEATH AND DIFFERENTIATION (2015)

Article Pathology

Age at Onset Should Be a Major Criterion for Subclassification of Colorectal Cancer

Jose Perea et al.

JOURNAL OF MOLECULAR DIAGNOSTICS (2014)

Article Biotechnology & Applied Microbiology

Nodal Promotes the Self-Renewal of Human Colon Cancer Stem Cells via an Autocrine Manner through Smad2/3 Signaling Pathway

Yuehua Gong et al.

BIOMED RESEARCH INTERNATIONAL (2014)

Article Oncology

CCN2 promotes keratinocyte adhesion and migration via integrin α5β1

Elizabeth Kiwanuka et al.

EXPERIMENTAL CELL RESEARCH (2013)

Review Biochemistry & Molecular Biology

Nodal signalling in embryogenesis and tumourigenesis

Daniela F. Quail et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2013)

Article Biochemical Research Methods

Genome engineering using the CRISPR-Cas9 system

F. Ann Ran et al.

NATURE PROTOCOLS (2013)

Article Biochemistry & Molecular Biology

CCN1: a novel inflammation-regulated biphasic immune cell migration modulator

Madlen Loebel et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2012)

Article Multidisciplinary Sciences

Comprehensive molecular characterization of human colon and rectal cancer

Donna M. Muzny et al.

NATURE (2012)

Article Biochemistry & Molecular Biology

Transmembrane Protein 147 (TMEM147) Is a Novel Component of the Nicalin-NOMO Protein Complex

Ulf Dettmer et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Biotechnology & Applied Microbiology

Differential expression analysis for sequence count data

Simon Anders et al.

GENOME BIOLOGY (2010)

Article Cell Biology

Regulation of human cripto-1 gene expression by TGF-β1 and BMP-4 in embryonal and colon cancer cells

Mario Mancino et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2008)

Article Biochemical Research Methods

Analyzing real-time PCR data by the comparative C-T method

Thomas D. Schmittgen et al.

NATURE PROTOCOLS (2008)

Article Biochemistry & Molecular Biology

The nicastrin-like protein nicalin regulates assembly and stability of the nicalin-nodal modulator (NOMO) membrane protein complex

Christof Haffner et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Review Developmental Biology

Nodal signaling: developmental roles and regulation

Michael M. Shen

DEVELOPMENT (2007)

Review Oncology

Role of transforming growth factor beta in human cancer

RL Elliott et al.

JOURNAL OF CLINICAL ONCOLOGY (2005)

Article Biochemistry & Molecular Biology

Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data

MH Dai et al.

NUCLEIC ACIDS RESEARCH (2005)

Article Biochemistry & Molecular Biology

Nicalin and its binding partner Nomo are novel Nodal signaling antagonists

C Haffner et al.

EMBO JOURNAL (2004)

Article Mathematical & Computational Biology

Exploration, normalization, and summaries of high density oligonucleotide array probe level data

RA Irizarry et al.

BIOSTATISTICS (2003)