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Depression and Quality of Life in Patients with Gliomas: A Narrative Review

Journal

JOURNAL OF CLINICAL MEDICINE
Volume 11, Issue 16, Pages -

Publisher

MDPI
DOI: 10.3390/jcm11164811

Keywords

glioma; depression; quality of life; mood disorders; antidepressants

Funding

  1. National Natural Science Foundation of China [81472860]
  2. Key R&D project of Hunan Province [2020DK2002]
  3. advanced talent introduction fund of Jishou University [91602-111900]
  4. Key Project of Developmental Biology and Breeding from Hunan Province [2022XKQ0205]

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Depression is a common complication in patients with gliomas, and it can severely affect their psychological well-being and quality of life. Risk factors for depression in these patients include female sex, unmarried status, low education level, high tumor grade, and a history of mental illness. Antidepressant use can improve the prognosis of patients with gliomas.
In patients with gliomas, depression is a common complication that may cause severe psychological barriers and deteriorate the patient's quality of life (QoL). Currently, the Hospital Anxiety and Depression Scale (HADS) is the most commonly used tool to diagnose depression in patients with gliomas. Female sex, unmarried status, low education level, high tumor grade, and a history of mental illness may increase the risks of depression and depressive symptoms in patients with gliomas. The QoL of patients with gliomas can be directly reduced by depression. Therefore, the evaluation and intervention of mood disorders could improve the overall QoL of patients with gliomas. Antidepressant use has become a treatment strategy for patients with gliomas and comorbid depression. This narrative review summarizes the current issues related to depression in patients with gliomas, including the prevalence, risk factors, and diagnostic criteria of depression as well as changes in QoL caused by comorbid depression and antidepressant use. The purpose of this review is to guide clinicians to assess the psychological status of patients with gliomas and to provide clinicians and oncologists with a new treatment strategy to improve the prognosis of such patients.

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