Journal
JOURNAL OF CLINICAL MEDICINE
Volume 11, Issue 20, Pages -Publisher
MDPI
DOI: 10.3390/jcm11206139
Keywords
BTKi; Bruton tyrosine kinase; multiple sclerosis; autoimmune disease; cancer; B-cell; treatment
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BTK is an important protein that plays a key role in cellular signaling and is involved in the development of various diseases, including malignancies and autoimmune disorders. Understanding its function and developing BTK inhibitors offer promising therapeutic options for these conditions.
Bruton's tyrosine kinase (BTK) is an important protein belonging to the tyrosine kinase family that plays a key role in the intracellular signaling and proliferation, migration, and survival of normal and malignant B-lymphocytes and myeloid cells. Understanding the role of BTK in the B-cell signaling pathway has led to the development of BTK inhibitors (BTKi) as effective therapies for malignancies of myeloid origin and exploration as a promising therapeutic option for other cancers. Given its central function in B-cell receptor signaling, inhibition of BTK is an attractive approach for the treatment of a wide variety of autoimmune diseases that involve aberrant B-cell function including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and multiple sclerosis (MS). Here, we review the role of BTK in different cell signaling pathways, the development of BTKi in B-cell malignancies, and their emerging role in the treatment of MS and other autoimmune disorders.
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