Journal
JOURNAL OF CLINICAL MEDICINE
Volume 11, Issue 19, Pages -Publisher
MDPI
DOI: 10.3390/jcm11195711
Keywords
morbidity; infant mortality; risk factor; omphalocele; outcome
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This study aimed to identify the main risk factors associated with an unfavorable prognosis in the case of omphalocele. The results showed that neonates who developed sepsis, acute renal failure, associated abnormalities, hemorrhagic disease, or received conservative treatment had an increased risk of death. Prematurity also increased the risk of death. All six independent variables contributed to 61.0% of the risk of death. The logistic regression model showed a good diagnostic accuracy in predicting the contribution of the variables to the risk of death. The study highlights the need for significant efforts to eliminate the risk factors for death in omphalocele patients.
Omphalocele is a congenital abdominal wall defect with a constant incidence in recent decades, sometimes representing a real burden for neonatal intensive care units due to prolonged hospitalization and the evolution to death. In our study, we aimed to detect the main risk factors of an unfavorable evolution in the case of omphalocele. Methods: Retrospective cohort study of all neonates with omphalocele treated in our tertiary pediatric hospital during the last three decades; from 158 patients, 139 patients were eligible for the study. We tried to determine the risk of death using logistic regression model. Results: If the neonate develops sepsis, then there is an increased risk (13.03 times) of evolution to death. Similarly, the risk of death is 10.82 times higher in the case of developing acute renal failure, 6.28 times higher in the case of associated abnormalities, 5.54 in the case of developing hemorrhagic disease, and 3.78 in the case of conservative treatment (applied for giant omphalocele or severe chromosomal abnormalities). Prematurity increases by 3.62 times the risk of death. All six independent variables contributed 61.0% to the risk of death. The area under the ROC curve is 0.91, meaning that the diagnostic accuracy of our logistic regression model is very good for predicting the contribution of the six independent variables to the risk of death. Conclusion: Although in the past 30 years we witnessed several improvements in the antenatal diagnosis and management of omphalocele, survival rate remained constant, 47.5% overall. Much effort is still needed to eliminate the risk factors for death in this condition.
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