4.7 Review

Advances and Remaining Challenges in the Treatment for Borderline Resectable and Locally Advanced Pancreatic Ductal Adenocarcinoma

Related references

Note: Only part of the references are listed.
Article Surgery

An evaluation of adjuvant chemotherapy following neoadjuvant chemotherapy and resection for borderline resectable and locally advanced pancreatic cancer

Chunmeng Zhang et al.

Summary: Adjuvant therapy (AT) following neoadjuvant therapy (NAT) and curative-intent resection does not improve overall survival in borderline resectable and locally advanced pancreatic cancer patients, except in cases with positive margins.

AMERICAN JOURNAL OF SURGERY (2022)

Article Oncology

Socioeconomic Disparities in Pancreas Cancer Resection and Survival in the Veterans Health Administration

Jonathan Pastrana Del Valle et al.

Summary: In the VHA system, factors such as race, marital status, and employment status are associated with pancreatic cancer resection, while geographic region and employment status are associated with survival after resection. However, factors like race, Hispanic ethnicity, marital status, and Social Deprivation Index are not independently associated with survival after resection. Further studies are needed to explore the basis for these inequities.

ANNALS OF SURGICAL ONCOLOGY (2022)

Review Oncology

Disparities in Access to Oncologic Care in Pancreatic Cancer: A Systematic Review

Annabelle L. Fonseca et al.

Summary: This article critically assesses and summarizes disparities in access to oncologic therapies for pancreatic cancer through a systematic review. The results show significant sociodemographic disparities in pancreatic cancer care, and multiple factors contribute to these disparities.

ANNALS OF SURGICAL ONCOLOGY (2022)

Article Oncology

High local failure rates despite high margin-negative resection rates in a cohort of borderline resectable and locally advanced pancreatic cancer patients treated with stereotactic body radiation therapy following multi-agent chemotherapy

Colin Hill et al.

Summary: Most BRPC/LAPC patients treated with induction multi-agent chemotherapy followed by SBRT successfully achieved R0 resection, however, locoregional failure remained common, indicating the need for further optimization of radiation delivery in this context.

CANCER MEDICINE (2022)

Article Oncology

Efficacy of Preoperative mFOLFIRINOX vs mFOLFIRINOX Plus Hypofractionated Radiotherapy for Borderline Resectable Adenocarcinoma of the Pancreas The A021501 Phase 2 Randomized Clinical Trial

Matthew H. G. Katz et al.

Summary: This randomized clinical trial found that treatment with neoadjuvant modified FOLFIRINOX alone was associated with favorable overall survival (OS) in patients with borderline resectable pancreatic ductal adenocarcinoma (PDAC) compared with treatment with modified FOLFIRINOX plus hypofractionated radiotherapy. Therefore, modified FOLFIRINOX represents a reference regimen in this setting.

JAMA ONCOLOGY (2022)

Article Surgery

Comparing neoadjuvant chemotherapy with or without radiation therapy for pancreatic ductal adenocarcinoma: National Cancer Database cohort analysis

Atsushi Oba et al.

Summary: This study evaluated the treatment outcome of neoadjuvant radiotherapy (RT) compared to neoadjuvant chemotherapy (NAC) in patients with pancreatic ductal adenocarcinoma (PDAC). Despite its association with negative margin resection, neoadjuvant chemoradiotherapy did not show a survival benefit over neoadjuvant chemotherapy and had a higher 90-day mortality rate.

BRITISH JOURNAL OF SURGERY (2022)

Article Oncology

Racial Disparity in Pancreatoduodenectomy for Borderline Resectable Pancreatic Adenocarcinoma

George Molina et al.

Summary: Analysis of data from patients with borderline resectable pancreatic adenocarcinoma showed that non-White patients were less likely to undergo pancreatic resection compared to White patients. This racial disparity was attributed to variation in care within hospitals, but disappeared if non-White patients received neoadjuvant therapy.

ANNALS OF SURGICAL ONCOLOGY (2021)

Article Oncology

Intraoperative Radiation Mitigates the Effect of Microscopically Positive Tumor Margins on Survival Among Pancreatic Adenocarcinoma Patients Treated with Neoadjuvant FOLFIRINOX and Chemoradiation

Yurie Sekigami et al.

Summary: The study analyzed the prognostic impact of R1 resection in PDAC patients who received total neoadjuvant therapy and intraoperative radiotherapy, finding that in patients who underwent radiotherapy, R1 resection did not have a significant impact on DFS and OS compared to the non-radiotherapy group.

ANNALS OF SURGICAL ONCOLOGY (2021)

Article Oncology

Adjuvant Chemotherapy After Neoadjuvant Chemotherapy for Pancreatic Cancer is Associated with Improved Survival for Patients with Low-Risk Pathology

Elizabeth J. Olecki et al.

Summary: This study examined the benefit of adjuvant chemotherapy (AT) for patients with pancreatic adenocarcinoma after completion of neoadjuvant chemotherapy (NT) and surgical resection. The results showed a significant survival benefit for subgroups with low-risk pathologic features, suggesting the addition of AT after NT may be beneficial for these patients.

ANNALS OF SURGICAL ONCOLOGY (2021)

Article Oncology

Multi-agent neoadjuvant chemotherapy improves survival in early-stage pancreatic cancer: A National Cancer Database analysis

Aileen Deng et al.

Summary: In patients with stage I/II pancreatic adenocarcinoma, multi-agent neoadjuvant therapy (MA NAT) showed improved median overall survival (mOS) compared to upfront resection and all other chemotherapy sequences, except the combination of neoadjuvant and adjuvant therapy. This suggests the potential benefit of using multi-agent neoadjuvant therapy in these patients.

EUROPEAN JOURNAL OF CANCER (2021)

Article Oncology

Pancreatic Adenocarcinoma, Version 2.2021

Margaret A. Tempero et al.

Summary: Pancreatic cancer is the fourth leading cause of cancer-related death in the United States, with a major challenge being advanced disease at diagnosis. While survival rates have not significantly changed, newer treatments, including targeted therapies, offer hope for patients. The manuscript focuses on systemic therapy approaches for locally advanced and metastatic disease.

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK (2021)

Article Oncology

Disparities in the Use of Neoadjuvant Therapy for Resectable Pancreatic Ductal Adenocarcinoma

Jordan M. Cloyd et al.

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK (2020)

Article Multidisciplinary Sciences

The actual 5-year survivors of pancreatic ductal adenocarcinoma based on real-world data

Axel Bengtsson et al.

SCIENTIFIC REPORTS (2020)

Review Gastroenterology & Hepatology

Neoadjuvant Treatment for Borderline Resectable Pancreatic Ductal Adenocarcinoma

Benedikt Kaufmann et al.

DIGESTIVE SURGERY (2019)

Article Oncology

Neoadjuvant therapy and pancreatic cancer: a national cancer database analysis

Ravi Shridhar et al.

JOURNAL OF GASTROINTESTINAL ONCOLOGY (2019)

Article Oncology

Intraoperative Radiotherapy in the Era of Intensive Neoadjuvant Chemotherapy and Chemoradiotherapy for Pancreatic Adenocarcinoma

Florence K. Keane et al.

AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS (2018)

Article Medicine, General & Internal

FOLFIRINOX or Gemcitabine as Adjuvant Therapy for Pancreatic Cancer

T. Conroy et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Radiology, Nuclear Medicine & Medical Imaging

CT evaluation after neoadjuvant FOLFIRINOX chemotherapy for borderline and locally advanced pancreatic adenocarcinoma

Mathilde Wagner et al.

EUROPEAN RADIOLOGY (2017)

Article Radiology, Nuclear Medicine & Medical Imaging

An evaluation of the accuracy of CT when determining resectability of pancreatic head adenocarcinoma after neoadjuvant treatment

Christophe Cassinotto et al.

EUROPEAN JOURNAL OF RADIOLOGY (2013)

Editorial Material Oncology

Pretreatment Assessment of Resectable and Borderline Resectable Pancreatic Cancer: Expert Consensus Statement

Mark P. Callery et al.

ANNALS OF SURGICAL ONCOLOGY (2009)

Article Surgery

Borderline resectable pancreatic cancer: The importance of this emerging stage of disease

Matthew H. G. Katz et al.

JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS (2008)

Article Surgery

National failure to operate on early stage pancreatic cancer

Karl Y. Bilimoria et al.

ANNALS OF SURGERY (2007)