4.7 Article

Human Milk Oligosaccharide Utilization in Intestinal Bifidobacteria Is Governed by Global Transcriptional Regulator NagR

Related references

Note: Only part of the references are listed.
Article Biotechnology & Applied Microbiology

Fucosylated Human Milk Oligosaccharide Foraging within the Species Bifidobacterium pseudocatenulatum Is Driven by Glycosyl Hydrolase Content and Specificity

Guy Shani et al.

Summary: This study identifies key gene differences among Bifidobacterium pseudocatenulatum isolates that may impact whether a microbe successfully colonizes an infant gut. The presence or absence of specific alpha-fucosidases seems to direct the strain-specific fucosylated HMO utilization pattern among bifidobacteria. Such knowledge furthers our understanding of how diet drives bacterial colonization of the infant gut.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2022)

Article Biotechnology & Applied Microbiology

Diversification of a Fucosyllactose Transporter within the Genus Bifidobacterium

Miriam N. Ojima et al.

Summary: In this study, the authors examined the HMO consumption phenotypes of two bifidobacterial species and found that the diversity of the FL transporter led to uptake specificities of fucosylated sugars ranging from simple trisaccharides to complex hexasaccharides. These findings explain the adaptation and proliferation of bifidobacteria in the competitive and HMO-rich infant gut environment.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2022)

Article Pediatrics

B. infantis EVC001 Is Well-Tolerated and Improves Human Milk Oligosaccharide Utilization in Preterm Infants in the Neonatal Intensive Care Unit

Sarah Bajorek et al.

Summary: B. infantis EVC001 is effective in colonizing the preterm infant gut and improving the utilization of human milk. The study showed that EVC001 infants had higher levels of B. infantis and better utilization of human milk oligosaccharides.

FRONTIERS IN PEDIATRICS (2022)

Article Microbiology

Dosing a synbiotic of human milk oligosaccharides and B. infantis leads to reversible engraftment in healthy adult microbiomes without antibiotics

Julie E. Button et al.

Summary: By pairing infant gut microbe B. infantis with human milk oligosaccharides (HMO) in a synbiotic approach, we found that B. infantis can engraft into the healthy adult gut and significantly influence the metabolites. This synbiotic method also shows promising results in complex microbial environments.

CELL HOST & MICROBE (2022)

Article Cell Biology

Bifidobacterium infantis treatment promotes weight gain in Bangladeshi infants with severe acute malnutrition

Michael J. Barratt et al.

Summary: Disrupted development of the gut microbiota is a contributing cause of childhood malnutrition. An experiment found that giving B. infantis combined with LNT can increase the abundance of B. infantis subspecies in infants with severe acute malnutrition and promote weight gain, but the effect is still much lower than in healthy controls. A B. infantis strain, Bg_2D9, with superior fitness may have potential in treating malnourished infants.

SCIENCE TRANSLATIONAL MEDICINE (2022)

Article Nutrition & Dietetics

Bifidobacterium Species Colonization in Infancy: A Global Cross-Sectional Comparison by Population History of Breastfeeding

Diana H. Taft et al.

Summary: Bifidobacterium colonization patterns in breastfed infants are related to a country's history of breastfeeding. This study emphasizes the importance of considering historical and cultural influences on the prevalence of gut commensals and understanding bacteria transmission patterns.

NUTRIENTS (2022)

Article Ecology

Priority effects shape the structure of infant-type Bifidobacterium communities on human milk oligosaccharides

Miriam N. Ojima et al.

Summary: This study applied assembly theory to investigate the formation of bifidobacterial communities in the infant gut. The results showed that arrival order and sugar consumption phenotypes significantly affected community formation. Bifidobacterium bifidum and Bifidobacterium longum subsp. infantis dominated through inhibitory priority effects, while Bifidobacterium breve benefited from facilitative priority effects and utilized a specific degradant to dominate. This study highlights the importance of initial community assembly and its impact on the maturation trajectory of the infant gut microbiota.

ISME JOURNAL (2022)

Article Multidisciplinary Sciences

Robust variation in infant gut microbiome assembly across a spectrum of lifestyles

Matthew R. Olm et al.

Summary: This research found significant differences in infant microbiome between industrialized countries and the Hadza tribe in non-industrialized nations, with close associations between lifestyle and microbiome distribution and function between mother-infant pairs.

SCIENCE (2022)

Article Pediatrics

Impact of Probiotic B. infantis EVC001 Feeding in Premature Infants on the Gut Microbiome, Nosocomially Acquired Antibiotic Resistance, and Enteric Inflammation

Marielle Nguyen et al.

Summary: The study found that feeding B. infantis EVC001 in preterm infants can significantly improve gut microbiota, reduce intestinal inflammation, facilitate the utilization of human milk oligosaccharides, and decrease the presence of antibiotic resistance genes.

FRONTIERS IN PEDIATRICS (2021)

Review Biochemistry & Molecular Biology

The genus Bifidobacterium: from genomics to functionality of an important component of the mammalian gut microbiota

Giulia Alessandri et al.

Summary: Members of the genus Bifidobacterium are dominant symbiotic inhabitants of the mammalian gastrointestinal tract, colonizing their elective niche through genetic strategies to adapt to the highly competitive environment.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2021)

Article Microbiology

Bifidobacterium species associated with breastfeeding produce aromatic lactic acids in the infant gut

Martin F. Laursen et al.

Summary: Breastfeeding-associated Bifidobacterium species can convert aromatic amino acids into aromatic lactic acids via an unrecognized enzyme, potentially impacting infant immune function. Longitudinal study of Danish infants showed that faecal concentrations of aromatic lactic acids are positively correlated with specific Bifidobacterium species abundance containing the enzyme. These microbial metabolites may have implications for early life immune function.

NATURE MICROBIOLOGY (2021)

Article Biochemistry & Molecular Biology

Bifidobacteria-mediated immune system imprinting early in life

Bethany M. Henrick et al.

Summary: Early immune-microbe interactions play a role in the development of allergies, asthma, and inflammatory diseases. Breastfeeding promotes healthier immune-microbe relationships by providing necessary nutrients to beneficial microbes. The lack of bifidobacteria and genes required for HMO utilization can lead to systemic inflammation and immune dysregulation in early life.
Article Gastroenterology & Hepatology

Next-generation prebiotic promotes selective growth of bifidobacteria, suppressing Clostridioides difficile

Rika Hirano et al.

Summary: The study identified Gal-beta 1,4-Rha as a next-generation prebiotic candidate that selectively promotes the growth of beneficial bacteria like Bifidobacterium without stimulating the growth of other prominent bacteria and pathogens. This prebiotic was found to suppress the growth of the enteric pathogen Clostridioides difficile, indicating its potential for preventing infections and improving gut health.

GUT MICROBES (2021)

Article Microbiology

Structure of a Core Promoter in Bifidobacterium longum NCC2705

Tomoya Kozakai et al.

JOURNAL OF BACTERIOLOGY (2020)

Article Multidisciplinary Sciences

Effects of microbiota-directed foods in gnotobiotic animals and undernourished children

Jeanette L. Gehrig et al.

SCIENCE (2019)

Article Public, Environmental & Occupational Health

Early-life gut microbiome modulation reduces the abundance of antibiotic-resistant bacteria

Giorgio Casaburi et al.

ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL (2019)

Article Multidisciplinary Sciences

Evolutionary adaptation in fucosyllactose uptake systems supports bifidobacteria-infant symbiosis

Mikiyasu Sakanaka et al.

SCIENCE ADVANCES (2019)

Article Cell Biology

Variable gene expression and parasite load predict treatment outcome in cutaneous leishmaniasis

Camila Farias Amorim et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

Article Multidisciplinary Sciences

The human gut microbiome in early-onset type 1 diabetes from the TEDDY study

Tommi Vatanen et al.

NATURE (2018)

Article Biotechnology & Applied Microbiology

Global transcriptional landscape and promoter mapping of the gut commensal Bifidobacterium breve UCC2003

Francesca Bottacini et al.

BMC GENOMICS (2017)

Article Biochemistry & Molecular Biology

Identification and characterization of a sulfoglycosidase from Bifidobacterium bifidum implicated in mucin glycan utilization

Toshihiko Katoh et al.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2017)

Article Biotechnology & Applied Microbiology

Glycosulfatase-Encoding Gene Cluster in Bifidobacterium breve UCC2003

Muireann Egan et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2016)

Article Multidisciplinary Sciences

A key genetic factor for fucosyllactose utilization affects infant gut microbiota development

Takahiro Matsuki et al.

NATURE COMMUNICATIONS (2016)

Article Microbiology

Transcriptional Regulation of Carbohydrate Utilization Pathways in the Bifidobacterium Genus

Matvei S. Khoroshkin et al.

FRONTIERS IN MICROBIOLOGY (2016)

Article Biochemistry & Molecular Biology

limma powers differential expression analyses for RNA-sequencing and microarray studies

Matthew E. Ritchie et al.

NUCLEIC ACIDS RESEARCH (2015)

Article Multidisciplinary Sciences

Dose-Response Analysis Using R

Christian Ritz et al.

PLOS ONE (2015)

Article Multidisciplinary Sciences

Persistent gut microbiota immaturity in malnourished Bangladeshi children

Sathish Subramanian et al.

NATURE (2014)

Article Microbiology

Comparative genomics and evolution of regulons of the Lacl-family transcription factors

Dmitry A. Ravcheev et al.

FRONTIERS IN MICROBIOLOGY (2014)

Article Biotechnology & Applied Microbiology

Comparison of the Compositions of the Stool Microbiotas of Infants Fed Goat Milk Formula, Cow Milk-Based Formula, or Breast Milk

Gerald W. Tannock et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2013)

Article Biochemistry & Molecular Biology

Functional diversification of ROK-family transcriptional regulators of sugar catabolism in the Thermotogae phylum

Marat D. Kazanov et al.

NUCLEIC ACIDS RESEARCH (2013)

Article Biotechnology & Applied Microbiology

Bifidobacterium longum subsp infantis ATCC 15697 α-Fucosidases Are Active on Fucosylated Human Milk Oligosaccharides

David A. Sela et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2012)

Review Biochemistry & Molecular Biology

Human milk oligosaccharides: Every baby needs a sugar mama

Lars Bode

GLYCOBIOLOGY (2012)

Article Biochemistry & Molecular Biology

Use of ChIP-Seq data for the design of a multiple promoter-alignment method

Ionas Erb et al.

NUCLEIC ACIDS RESEARCH (2012)

Article Biochemistry & Molecular Biology

Control of Proteobacterial Central Carbon Metabolism by the HexR Transcriptional Regulator A CASE STUDY IN SHEWANELLA ONEIDENSIS

Semen A. Leyn et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

Physiology of Consumption of Human Milk Oligosaccharides by Infant Gut-associated Bifidobacteria

Sadaki Asakuma et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

An Infant-associated Bacterial Commensal Utilizes Breast Milk Sialyloligosaccharides

David A. Sela et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Biotechnology & Applied Microbiology

Distribution of In Vitro Fermentation Ability of Lacto-N-Biose I, a Major Building Block of Human Milk Oligosaccharides, in Bifidobacterial Strains

Jin-zhong Xiao et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2010)

Article Biochemical Research Methods

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

Mark D. Robinson et al.

BIOINFORMATICS (2010)

Article Biochemistry & Molecular Biology

Dissecting the in Vivo Metabolic Potential of Two Human Gut Acetogens

Federico E. Rey et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

RegPrecise: a database of curated genomic inferences of transcriptional regulatory interactions in prokaryotes

Pavel S. Novichkov et al.

NUCLEIC ACIDS RESEARCH (2010)

Article Multidisciplinary Sciences

Genome analysis of Bifidobacterium bifidum PRL2010 reveals metabolic pathways for host-derived glycan foraging

Francesca Turroni et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Biotechnology & Applied Microbiology

Bifidobacterium bifidum lacto-N-biosidase, a critical enzyme for the degradation of human milk oligosaccharides with a type 1 structure

Jun Wada et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2008)

Article Multidisciplinary Sciences

The genome sequence of Bifidobacterium longum subsp infantis reveals adaptations for milk utilization within the infant microbiome

D. A. Sela et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Review Microbiology

Cytoplasmic steps of peptidoglycan biosynthesis

Helene Barreteau et al.

FEMS MICROBIOLOGY REVIEWS (2008)

Article Biotechnology & Applied Microbiology

Identification of N-acetylhexosamine 1-kinase in the complete lacto-N-biose I/Galacto-N-Biose metabolic pathway in Bifidobactetium longum

Mamoru Nishimoto et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2007)

Article Biotechnology & Applied Microbiology

Novel putative galactose operon involving lacto-N-biose phosphorylase in Bifidobacterium longum

M Kitaoka et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2005)

Article Biochemistry & Molecular Biology

WebLogo: A sequence logo generator

GE Crooks et al.

GENOME RESEARCH (2004)

Article Biochemistry & Molecular Biology

Software for analysis of bacterial genomes

AA Mironov et al.

MOLECULAR BIOLOGY (2000)