4.7 Article

Salmonella-mediated blood-brain barrier penetration, tumor homing and tumor microenvironment regulation for enhanced chemo/bacterial glioma therapy

Related references

Note: Only part of the references are listed.
Article Chemistry, Multidisciplinary

Smart Nanomedicine to Enable Crossing Blood-Brain Barrier Delivery of Checkpoint Blockade Antibody for Immunotherapy of Glioma

Hairong Wang et al.

Summary: In this study, a BBB-crossing copolymer was successfully fabricated using a choline analogue MPC, leading to efficient delivery of ICB therapy in a glioma model and significantly prolonging animal survival.

ACS NANO (2022)

Article Pharmacology & Pharmacy

The impact of protein corona on the biological behavior of targeting nanomedicines

Masoud Farshbaf et al.

Summary: In order to successfully translate targeting nanomedicines from bench to bedside, it is necessary to address the common issues of rapid clearance and off-target accumulation. This phenomenon, known as protein corona (PC) formation, occurs when targeting nanoparticles encounter the bloodstream and interact with plasma proteins. The present review discusses the impact of PC on the biological behavior of targeting nanomedicines, as well as the best simulated environment and latest characterization techniques for PC analysis. The article also highlights recent progress in manipulating nano-bio interfaces to achieve optimal therapeutic outcomes.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

Article Chemistry, Multidisciplinary

Macrophage-targeted nanomedicine for chronic diseases immunotherapy

Yuejia Song et al.

Summary: This review summarizes the recent progress of macrophage-targeted nanomedicine for chronic diseases immunotherapy. The origin, polarization, and biological functions of macrophages are introduced. The disorder of macrophages in different chronic diseases is reviewed, and the pathological contributions of macrophages in representative diseases are discussed in detail. Strategies to regulate macrophages for disease immunotherapy, with a focus on bio-functional nanomaterials, are summarized. Methods for macrophage-targeting delivery nanosystems are discussed. Finally, the potential clinical translation and the development of novel macrophage-targeting nanomedicine for precise, effective, and biosafe therapy are speculated.

CHINESE CHEMICAL LETTERS (2022)

Article Chemistry, Multidisciplinary

PSMA-targeted nanoparticles for specific penetration of blood-brain tumor barrier and combined therapy of brain metastases

Jiang Ni et al.

Summary: Breast cancer brain metastases (BCBM) are a major cause of morbidity and mortality among breast cancer patients because systemic drug therapy is often ineffective due to poor penetration through the blood-brain tumor barrier (BTB). This study found a nanotechnology approach that can overcome the BTB and target BCBM effectively, showing promising results in preclinical studies.

JOURNAL OF CONTROLLED RELEASE (2021)

Article Pharmacology & Pharmacy

Escape from abluminal LRP1-mediated clearance for boosted nanoparticle brain delivery and brain metastasis treatment

Naveed Ullah Khan et al.

Summary: Breast cancer brain metastases (BCBMs) are challenging due to their intracranial location and limited response to chemotherapy. Research has shown promising results with nanoparticles (NPs-K-s-A) targeting LRP1 and MMP1 to overcome the blood-brain barrier and enhance drug delivery, leading to improved therapeutic outcomes in mice with BCBMs. This fusion peptide-based drug delivery strategy shows potential for clinical management of BCBMs.

ACTA PHARMACEUTICA SINICA B (2021)

Article Chemistry, Multidisciplinary

Trojan Horse Salmonella Enabling Tumor Homing of Silver Nanoparticles via Neutrophil Infiltration for Synergistic Tumor Therapy and Enhanced Biosafety

Ze Mi et al.

Summary: Researchers enhanced the efficacy and biosafety of Salmonella by using silver nanoparticles, enabling tumor-targeting AgNPs to exert multiple functions in the tumor and ultimately eliminate the tumor with high biosafety.

NANO LETTERS (2021)

Article Chemistry, Multidisciplinary

A Virus-Mimicking Nucleic Acid Nanogel Reprograms Microglia and Macrophages for Glioblastoma Therapy

Xihui Gao et al.

Summary: Immunotherapy is a promising approach for treating cancers, but its effectiveness in glioblastoma treatment is limited due to the immunosuppressive tumor microenvironment. A virus-mimicking membrane-coated nucleic acid nanogel, Vir-Gel, has been developed to reprogram microglia and macrophages from a pro-invasive M2 phenotype to an anti-tumor M1 phenotype. This approach significantly enhances the targetability and cell uptake efficiency of therapeutic miRNA, demonstrating improved tumor inhibition efficacy.

ADVANCED MATERIALS (2021)

Article Medicine, Research & Experimental

Neutrophils as an emerging therapeutic target and tool for cancer therapy

Md Abdus Subhan et al.

Summary: This review elucidates the dual function of neutrophils in cancer treatment, highlighting their potential for drug delivery and targeting in pre-clinical models.

LIFE SCIENCES (2021)

Article Nanoscience & Nanotechnology

Immunostimulant hydrogel for the inhibition of malignant glioma relapse post-resection

Jing Zhang et al.

Summary: The study introduces an injectable hydrogel system that stimulates tumoricidal immunity after GBM surgical resection, effectively reducing its recurrence. This system induces immunogenic cell death and sustained T-cell infiltration to attack residual tumor cells, significantly suppressing postoperative GBM recurrence.

NATURE NANOTECHNOLOGY (2021)

Review Chemistry, Multidisciplinary

Rethinking CRITID Procedure of Brain Targeting Drug Delivery: Circulation, Blood Brain Barrier Recognition, Intracellular Transport, Diseased Cell Targeting, Internalization, and Drug Release

Shaobo Ruan et al.

Summary: This review analyzes the typical delivery process of nanoparticle-based brain-targeting drug delivery systems, proposing a six-step CRITID delivery cascade to provide a deep understanding of the issues and requirements for designing efficient and specific systems. Strategies for troubleshooting these issues are reviewed and state-of-the-art design features are highlighted to guide the development of more effective brain-targeting drug delivery systems.

ADVANCED SCIENCE (2021)

Article Engineering, Biomedical

The protein corona hampers the transcytosis of transferrin-modified nanoparticles through blood-brain barrier and attenuates their targeting ability to brain tumor

Wei Xiao et al.

Summary: The modification of targeting ligands on nanoparticles is expected to enhance therapeutic delivery to diseased tissues, but the protein corona formed when exposed to the blood stream can hinder this process. Research shows that the protein corona has different impacts on receptor targeting, lysosomal escape, and protein transcytosis in BBB. After crossing the BBB, transferrin retains its targeting specificity towards brain tumor cells.

BIOMATERIALS (2021)

Article Chemistry, Multidisciplinary

Unmasking CSF protein corona: Effect on targeting capacity of nanoparticles

Yazhen Wang et al.

Summary: The formation of protein corona from cerebrospinal fluid can impact the targeting capability of nanoparticles, leading to the loss of active targeting specificity and alteration of their cellular uptake pathways.

JOURNAL OF CONTROLLED RELEASE (2021)

Review Engineering, Biomedical

Neutrophil and Nanoparticles Delivery to Tumor: Is It Going to Carry That Weight?

Daniil A. Vishnevskiy et al.

Summary: The application of cell carriers for transporting nanodrugs to tumors, particularly neutrophils, shows great potential. However, several conceptual and technical issues need to be addressed for successful clinical translation of this technology.

ADVANCED HEALTHCARE MATERIALS (2021)

Article Engineering, Biomedical

Sialic acid conjugate-modified liposomes enable tumor homing of epirubicin via neutrophil/monocyte infiltration for tumor therapy

Junqiang Ding et al.

Summary: The study developed a novel nano-platform for tumor therapy by utilizing neutrophils and monocytes as drug carriers, achieving enhanced tumor targeting efficiency through liposome modification. The research provided potential clinical applications and contributed to the development of a new drug delivery platform for cancer treatment.

ACTA BIOMATERIALIA (2021)

Article Engineering, Biomedical

Inflammatory tumor microenvironment responsive neutrophil exosomes-based drug delivery system for targeted glioma therapy

Jun Wang et al.

Summary: NEs-Exos system exhibits neutrophil-like chemotactic function and BBB penetration capability, efficiently suppressing tumor growth and prolonging survival time in a glioma mouse model.

BIOMATERIALS (2021)

Article Oncology

Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma

Toshiro Hara et al.

Summary: The mesenchymal subtype of glioblastoma is believed to be influenced by both cancer cell-intrinsic alterations and external cellular interactions, with macrophages inducing a transition of glioblastoma cells into mesenchymal-like states. This transition is mediated by macrophage-derived oncostatin M (OSM) interacting with its receptors on glioblastoma cells, leading to the activation of STAT3. This study also reveals that mesenchymal-like glioblastoma states are associated with increased expression of a mesenchymal program in macrophages and enhanced cytotoxicity of T cells, suggesting potential therapeutic implications.

CANCER CELL (2021)

Editorial Material Oncology

Macrophage-tumor cell intertwine drives the transition into a mesenchymal-like cellular state of glioblastoma

Zhihong Chen et al.

Summary: The study demonstrates that macrophages can induce a transition of glioblastoma cells into a mesenchymal-like cellular state, which is associated with an increased mesenchymal program in macrophages themselves and enhanced cytotoxicity of T cells.

CANCER CELL (2021)

Article Chemistry, Multidisciplinary

Selective transferrin coating as a facile strategy to fabricate BBB-permeable and targeted vesicles for potent RNAi therapy of brain metastatic breast cancer in vivo

Yaohua Wei et al.

Summary: Transferrinfunctionalized chimeric polymersomes carrying siRNA against polo-like kinase 1 (Tf@TBP-CPs-siPLK1) showed significant efficacy in treating brain metastatic breast cancer by promoting blood-brain barrier penetration and high tumor cell specificity.

JOURNAL OF CONTROLLED RELEASE (2021)

Article Chemistry, Multidisciplinary

Phototherapy Facilitates Tumor Recruitment and Activation of Natural Killer T cells for Potent Cancer Immunotherapy

Min Li et al.

Summary: The study demonstrates that the use of photothermal therapy can enhance the antitumor ability of adoptively transferred NKT cells, leading to excellent growth inhibition of local tumors and efficient rejection of distant tumors. It also triggers long-term immunological memory to prevent tumor recurrence, showing promising potential for cancer immunotherapy.

NANO LETTERS (2021)

Article Multidisciplinary Sciences

Synergistic effect of tumor chemo-immunotherapy induced by leukocyte-hitchhiking thermal-sensitive micelles

Jing Qi et al.

Summary: The study introduces E-selectin-modified thermal-sensitive micelles loaded with doxorubicin and an adenosine A2 receptor antagonist to enhance chemotherapy-induced anti-tumor immune responses. This strategy not only increases the tumor accumulation of drugs by hitchhiking with leukocytes, but also improves the immunotherapeutic effects of chemotherapy drugs.

NATURE COMMUNICATIONS (2021)

Article Biochemistry & Molecular Biology

FNDC5 alleviates oxidative stress and cardiomyocyte apoptosis in doxorubicin-induced cardiotoxicity via activating AKT

Xin Zhang et al.

CELL DEATH AND DIFFERENTIATION (2020)

Article Multidisciplinary Sciences

Mechanisms and therapeutic implications of hypermutation in gliomas

Mehdi Touat et al.

NATURE (2020)

Article Chemistry, Multidisciplinary

Bacterial outer membrane vesicles as a platform for biomedical applications: An update

Min Li et al.

JOURNAL OF CONTROLLED RELEASE (2020)

Review Engineering, Biomedical

Bacteria-Derived Nanoparticles: Multifunctional Containers for Diagnostic and Therapeutic Applications

Lin Liu et al.

ADVANCED HEALTHCARE MATERIALS (2020)

Article Multidisciplinary Sciences

A new painkiller nanomedicine to bypass the blood-brain barrier and the use of morphine

Jiao Feng et al.

SCIENCE ADVANCES (2019)

Article Multidisciplinary Sciences

Glutamatergic synaptic input to glioma cells drives brain tumour progression

Varun Venkataramani et al.

NATURE (2019)

Review Microbiology

Types and origins of bacterial membrane vesicles

Masanori Toyofuku et al.

NATURE REVIEWS MICROBIOLOGY (2019)

Article Chemistry, Multidisciplinary

Neutrophil-Based Drug Delivery Systems

Dafeng Chu et al.

ADVANCED MATERIALS (2018)

Review Biochemistry & Molecular Biology

Understanding the tumor immune microenvironment (TIME) for effective therapy

Mikhail Binnewies et al.

NATURE MEDICINE (2018)

Review Oncology

Tumour-targeting bacteria engineered to fight cancer

Shibin Zhou et al.

NATURE REVIEWS CANCER (2018)

Review Immunology

Neutrophils in Homeostasis, Immunity, and Cancer

Jose Angel Nicolas-Avila et al.

IMMUNITY (2017)

Review Immunology

Salmonella infection: Interplay between the bacteria and host immune system

Jonathan R. Kurtz et al.

IMMUNOLOGY LETTERS (2017)

Article Nanoscience & Nanotechnology

Neutrophil-mediated anticancer drug delivery for suppression of postoperative malignant glioma recurrence

Jingwei Xue et al.

NATURE NANOTECHNOLOGY (2017)

Review Pharmacology & Pharmacy

The design of peptide-amphiphiles as functional ligands for liposomal anticancer drug and gene delivery

Huihui Kuang et al.

ADVANCED DRUG DELIVERY REVIEWS (2017)

Article Chemistry, Multidisciplinary

Nanoparticles Coated with Neutrophil Membranes Can Effectively Treat Cancer Metastasis

Ting Kang et al.

ACS NANO (2017)

Article Multidisciplinary Sciences

A Salmonella nanoparticle mimic overcomes multidrug resistance in tumours

Regino Mercado-Lubo et al.

NATURE COMMUNICATIONS (2016)

Review Pharmacology & Pharmacy

Progress and perspectives on targeting nanoparticles for brain drug delivery

Huile Gao

ACTA PHARMACEUTICA SINICA B (2016)

Article Gastroenterology & Hepatology

Optimizing &ITSalmonella enterica&IT serovar Typhimurium for bacteria-mediated tumor therapy

Sebastian Felgner et al.

GUT MICROBES (2016)

Article Biotechnology & Applied Microbiology

Engineering of Bacteria for the Visualization of Targeted Delivery of a Cytolytic Anticancer Agent

Sheng-Nan Jiang et al.

MOLECULAR THERAPY (2013)

Review Immunology

Neutrophil recruitment and function in health and inflammation

Elzbieta Kolaczkowska et al.

NATURE REVIEWS IMMUNOLOGY (2013)

Article Cell Biology

Coupled for Cross-Presentation in Tumor Immunotherapy

Baoxu Pang et al.

SCIENCE TRANSLATIONAL MEDICINE (2010)

Article Oncology

Containment of tumor-colonizing bacteria by host neutrophils

Kathrin Westphal et al.

CANCER RESEARCH (2008)

Review Multidisciplinary Sciences

Cancer-related inflammation

Alberto Mantovani et al.

NATURE (2008)