Journal
EBIOMEDICINE
Volume 85, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.ebiom.2022.104319
Keywords
Gallbladder cancer; Single-cell RNA sequencing; Human endogenous retrovirus; Enhancer; Immune checkpoint; HERVH
Funding
- National Natural Science Foundation of China [31970176, 81972256]
- Innovation Capacity Building Project of Jiangsu province [BM2020019]
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This study investigates the role of human endogenous retroviruses in gallbladder cancer, aiming to find new diagnostic and therapeutic approaches.
Background Gallbladder cancer (GBC), the most common malignancy of the biliary tract, shows late diagnosis and low survival rate and requires continued search for new diagnostic biomarkers and therapeutic targets. Human endogenous retroviruses (HERVs) are specifically prone to be reactivated in diverse cancers and are implicated in cancer progression and immunotherapy.
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