Journal
JOURNAL FOR IMMUNOTHERAPY OF CANCER
Volume 10, Issue 9, Pages -Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/jitc-2021-002976
Keywords
Cytokines; Macrophages; Tumor Microenvironment; Metabolic Networks and Pathways; Tumor Biomarkers
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Funding
- NUHS [A-0002469-00-00]
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Regular exercise may have significant implications for tumor and stromal cells in the tumor microenvironment by modulating iron bioavailability, transport, and metabolism, affecting multiple tumor-autonomous and stromal cell responses.
Despite accumulating evidence that supports the beneficial effects of physical exercise in inhibiting cancer progression, whether exercise modulates its effects through systemic and cellular changes in iron metabolism and immune-tumor crosstalk is unknown. Cancer cells have greater metabolic requirements than normal cells, with their survival and proliferation depending largely on iron bioavailability. Although iron is an essential mineral for mitogenesis, it also participates in a form of iron-dependent programmed cell death termed ferroptosis. In this short hypothesis paper, we speculate that modulating iron bioavailability, transport and metabolism with regular exercise can have significant implications for tumor and stromal cells in the tumor microenvironment, by affecting multiple tumor-autonomous and stromal cell responses.
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