4.8 Article

Single-cell multiomics identifies clinically relevant mesenchymal stem-like cells and key regulators for MPNST malignancy

Related references

Note: Only part of the references are listed.
Article Oncology

Targeting MARCO and IL37R on Immunosuppressive Macrophages in Lung Cancer Blocks Regulatory T Cells and Supports Cytotoxic Lymphocyte Function

Linnea La Fleur et al.

Summary: The research revealed the correlation between MARCO-expressing TAMs and poor clinical outcomes in patients with non-small cell lung cancer. These TAMs block the antitumor activities of NK cells and T cells, and gain an immune-suppressive phenotype through the release of IL37. Targeting MARCO or IL37R may remodel the immune-suppressive microenvironment in lung cancer patients.

CANCER RESEARCH (2021)

Review Oncology

Systemic Options for Malignant Peripheral Nerve Sheath Tumors

Ayesha Hassan et al.

Summary: Malignant peripheral nerve sheath tumors (MPNSTs) are rare mesenchymal neoplasms that pose a therapeutic challenge due to lack of effective targeted therapy. Although standard chemotherapy regimens exist, there is a particular need for novel therapeutic strategies, especially for neurofibromatosis type 1 (NF1)-associated MPNST.

CURRENT TREATMENT OPTIONS IN ONCOLOGY (2021)

Article Genetics & Heredity

ArchR is a scalable software package for integrative single-cell chromatin accessibility analysis

Jeffrey M. Granja et al.

Summary: ArchR is a software suite for single-cell chromatin accessibility analysis in R, allowing fast and comprehensive analysis and processing of single-cell chromatin accessibility data, providing multiple analysis functions, and capable of handling large amounts of single-cell data in a short period of time.

NATURE GENETICS (2021)

Article Multidisciplinary Sciences

Reactivation of the pluripotency program precedes formation of the cranial neural crest

Antoine Zalc et al.

Summary: A neuroepithelial precursor population characterized by pluripotency transcription factors is essential for craniofacial development, giving rise to cranial neural crest cells. Through transient reactivation of the pluripotency factor Oct4, cranial neural crest cells expand their developmental potential to differentiate into mesenchymal cells. The open chromatin landscapes of Oct4(+) CNCC precursors resemble those of epiblast stem cells, suggesting priming for mesenchymal programs.

SCIENCE (2021)

Article Multidisciplinary Sciences

Inference and analysis of cell-cell communication using CellChat

Suoqin Jin et al.

Summary: By constructing an interaction database and developing the tool CellChat, the authors quantitatively inferred and analyzed cell-cell communication networks, revealing important signaling inputs and outputs between cells, and achieved classification of conserved and context-specific pathways.

NATURE COMMUNICATIONS (2021)

Article Cell & Tissue Engineering

Stem-like cells drive NF1-associated MPNST functional heterogeneity and tumor progression

Daochun Sun et al.

Summary: NF1-associated MPNSTs originate from benign peripheral nerve neurofibromas and a rare stem-cell-like cell population within MPNSTs plays a crucial role in tumor initiation and relapse. By isolating and characterizing these cells, a cancer stem cell-specific gene expression signature has been identified, with potential therapeutic implications. Targeting cancer stem cells in combination with antimitotic chemotherapy shows promise in inhibiting tumor growth and prolonging survival, with implications for MPNST therapy development.

CELL STEM CELL (2021)

Article Oncology

Single-cell analyses reveal YAP/TAZ as regulators of stemness and cell plasticity in glioblastoma

Martina Castellan et al.

Summary: The study identified YAP/TAZ coactivators as master regulators of GSCs in glioblastoma, essential for tumor maintenance. Their inhibition locks GBM cells into a non-tumorigenic state, preventing regeneration of GSC-like cells.

NATURE CANCER (2021)

Review Biochemistry & Molecular Biology

YAP/TAZ: Drivers of Tumor Growth, Metastasis, and Resistance to Therapy

Barry J. Thompson

BIOESSAYS (2020)

Review Genetics & Heredity

Clinical implications of intratumor heterogeneity: challenges and opportunities

Santiago Ramon y Cajal et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2020)

Article Multidisciplinary Sciences

Single-cell transcriptional diversity is a hallmark of developmental potential

Gunsagar S. Gulati et al.

SCIENCE (2020)

Article Biochemistry & Molecular Biology

Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer

Lei Zhang et al.

Article Multidisciplinary Sciences

Redefining the heterogeneity of peripheral nerve cells in health and autoimmunity

Jolien Wolbert et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Oncology

A framework for advancing our understanding of cancer-associated fibroblasts

Erik Sahai et al.

NATURE REVIEWS CANCER (2020)

Review Oncology

Malignant Peripheral Nerve Sheath Tumors: From Epigenome to Bedside

Justin Korfhage et al.

MOLECULAR CANCER RESEARCH (2019)

Article Biotechnology & Applied Microbiology

Determining cell type abundance and expression from bulk tissues with digital cytometry

Aaron M. Newman et al.

NATURE BIOTECHNOLOGY (2019)

Article Biochemistry & Molecular Biology

Comprehensive Integration of Single-Cell Data

Tim Stuart et al.

Article Biochemistry & Molecular Biology

An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma

Cyril Neftel et al.

Review Biochemistry & Molecular Biology

TGF--Mediated Epithelial-Mesenchymal Transition and Cancer Metastasis

Yang Hao et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Cell Biology

Reconstruction of the Global Neural Crest Gene Regulatory Network In Vivo

Ruth M. Williams et al.

DEVELOPMENTAL CELL (2019)

Article Cell & Tissue Engineering

Mesenchymal Precursor Cells in Adult Nerves Contribute to Mammalian Tissue Repair and Regeneration

Matthew J. Carr et al.

CELL STEM CELL (2019)

Article Biotechnology & Applied Microbiology

Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics

Kelly Street et al.

BMC GENOMICS (2018)

Article Biochemistry & Molecular Biology

OmicsNet: a web-based tool for creation and visual analysis of biological networks in 3D space

Guangyan Zhou et al.

NUCLEIC ACIDS RESEARCH (2018)

Article Oncology

Cancer cell plasticity: Impact on tumor progression and therapy response

Victoria da Silva-Diz et al.

SEMINARS IN CANCER BIOLOGY (2018)

Article Biochemistry & Molecular Biology

MEG3 Long Noncoding RNA Contributes to the Epigenetic Regulation of Epithelial-Mesenchymal Transition in Lung Cancer Cell Lines

Minoru Terashima et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

Review Oncology

EMT, CSCs, and drug resistance: the mechanistic link and clinical implications

Tsukasa Shibue et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2017)

Article Biochemistry & Molecular Biology

DGIdb 3.0: a redesign and expansion of the drug–gene interaction database

Kelsy C Cotto et al.

NUCLEIC ACIDS RESEARCH (2017)

Article Multidisciplinary Sciences

The genomic landscape of malignant peripheral nerve sheath tumors: diverse drivers of Ras pathway activation

Andrew S. Brohl et al.

SCIENTIFIC REPORTS (2017)

Article Biochemical Research Methods

Scater: pre-processing, quality control, normalization and visualization of single-cell RNA-seq data in R

Davis J. McCarthy et al.

BIOINFORMATICS (2017)

Review Oncology

EMT, cell plasticity and metastasis

Christine L. Chaffer et al.

CANCER AND METASTASIS REVIEWS (2016)

Article Multidisciplinary Sciences

Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma

Itay Tirosh et al.

NATURE (2016)

Review Oncology

Nestin as a marker of cancer stem cells

Jakub Neradil et al.

CANCER SCIENCE (2015)

Article Biochemistry & Molecular Biology

Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets

Evan Z. Macosko et al.

Article Biochemistry & Molecular Biology

The EMT activator ZEB1 promotes tumor growth and determines differential response to chemotherapy in mantle cell lymphoma

E. Sanchez-Tillo et al.

CELL DEATH AND DIFFERENTIATION (2014)

Article Oncology

Malignant Peripheral Nerve Sheath Tumors

Mohamad Farid et al.

ONCOLOGIST (2014)

Review Biochemistry & Molecular Biology

Microenvironmental regulation of tumor progression and metastasis

Daniela F. Quail et al.

NATURE MEDICINE (2013)

Article Multidisciplinary Sciences

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

A Subramanian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemistry & Molecular Biology

Diaphanous-related formins bridge Rho GTPase and Src tyrosine kinase signaling

T Tominaga et al.

MOLECULAR CELL (2000)