☆ 4.8 Article

POU2AF2/C11orf53 functions as a coactivator of POU2F3 by maintaining chromatin accessibility and enhancer activity

SCIENCE ADVANCES (2022)

Related references

Note: Only part of the references are listed.

Article Multidisciplinary Sciences

OCA-T1 and OCA-T2 are coactivators of POU2F3 in the tuft cell lineage

Xiaoli S. Wu et al.

Summary: Tuft cells are rare chemosensory cells that play a role in coordinating immune and neural responses to foreign pathogens. Recent studies have shown their involvement in small-cell lung cancer. This study reveals the critical role of POU2F3-OCA-T complex in tuft cell identity and its potential as a molecular vulnerability in small-cell lung cancer.

NATURE (2022)

Add to Collection

Article Medicine, General & Internal

Small-cell lung cancer

Charles M. Rudin et al.

Summary: Small-cell lung cancer is a type of lung cancer characterized by high proliferative rate, early metastasis, and poor prognosis, strongly associated with tobacco carcinogens. Most patients are diagnosed with metastatic disease, with only a small fraction having potentially curative earlier-stage disease. Genomic profiling reveals extensive chromosomal rearrangements and high mutation burden in SCLC, often involving inactivation of TP53 and RB1 tumor suppressor genes.

NATURE REVIEWS DISEASE PRIMERS (2021)

Add to Collection

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Add to Collection

Review Oncology

Molecular profiles of small cell lung cancer subtypes: Therapeutic implications

Anna Schwendenwein et al.

Summary: Small cell lung cancer (SCLC) is a highly lethal subtype of lung cancer characterized by rapid doubling time and high propensity to metastasize. Recent research has shown intratumoral heterogeneity within SCLC, leading to the development of novel subtype-specific classifications based on neuroendocrine and molecular features, which may have important implications for clinical treatment.

MOLECULAR THERAPY-ONCOLYTICS (2021)

Add to Collection

Article Multidisciplinary Sciences

Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes

Christina M. Bebber et al.

Summary: The loss of TP53 and RB1 in treatment-naive small cell lung cancer (SCLC) indicates a need to inactivate cell death pathways prior to therapy. This study identifies non-neuroendocrine (NE) SCLC as vulnerable to ferroptosis and neuroendocrine (NE) SCLC as susceptible to TRX pathway inhibition, with combining these treatments showing promise in overcoming subtype plasticity in SCLC.

NATURE COMMUNICATIONS (2021)

Add to Collection

Article Oncology

PAX9 Determines Epigenetic State Transition and Cell Fate in Cancer

Zibo Zhao et al.

Summary: This study highlights the oncogenic function of the PAX9/NuRD complex epigenetic axis in human SCLC and suggests that reactivating primed enhancers may be a potential therapeutic strategy for treating SCLC expressing high levels of PAX9, offering insights into personalized therapeutic approaches targeting the PAX9-regulated network in small cell lung cancer.

CANCER RESEARCH (2021)

Add to Collection

Article Genetics & Heredity

ASXL3 bridges BRD4 to BAP1 complex and governs enhancer activity in small cell lung cancer

Aileen Patricia Szczepanski et al.

GENOME MEDICINE (2020)

Add to Collection

Article Cell Biology

SCLC-CellMiner: A Resource for Small Cell Lung Cancer Cell Line Genomics and Pharmacology Based on Genomic Signatures

Camille Tlemsani et al.

CELL REPORTS (2020)

Add to Collection

Article Oncology

Cancer treatment and survivorship statistics, 2019

Kimberly D. Miller et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2019)

Add to Collection

Correction Oncology

Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data (vol 19, pg 289, 2019)

Charles M. Rudin et al.

NATURE REVIEWS CANCER (2019)

Add to Collection

Article Cell Biology

POU2F3 is a master regulator of a tuft cell-like variant of small cell lung cancer

Yu-Han Huang et al.

GENES & DEVELOPMENT (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy

Lu Wang et al.

NATURE MEDICINE (2018)

Add to Collection

Article Oncology

Intertumoral Heterogeneity in SCLC Is Influenced by the Cell Type of Origin

Dian Yang et al.

CANCER DISCOVERY (2018)

Add to Collection

Article Oncology

Small cell lung cancer tumors and preclinical models display heterogeneity of neuroendocrine phenotypes

Wei Zhang et al.

TRANSLATIONAL LUNG CANCER RESEARCH (2018)

Add to Collection

Article Oncology

Vulnerability of Small-Cell Lung Cancer to Apoptosis Induced by the Combination of BET Bromodomain Proteins and BCL2 Inhibitors

Lloyd T. Lam et al.

MOLECULAR CANCER THERAPEUTICS (2017)

Add to Collection

Review Oncology

Small-cell lung cancer: what we know, what we need to know and the path forward

Adi F. Gazdar et al.

NATURE REVIEWS CANCER (2017)

Add to Collection

Article Oncology

Chemosensitive Relapse in Small Cell Lung Cancer Proceeds through an EZH2-SLFN11 Axis

Eric E. Gardner et al.

CANCER CELL (2017)

Add to Collection

Article Immunology

Oct1 and OCA-B are selectively required for CD4 memory T cell function

Arvind Shakya et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2015)

Add to Collection

Article Oncology

Sensitivity of Small Cell Lung Cancer to BET Inhibition Is Mediated by Regulation of ASCL1 Gene Expression

Ryan Lenhart et al.

MOLECULAR CANCER THERAPEUTICS (2015)

Add to Collection

Article Medicine, Research & Experimental

Functional analysis of the nuclear localization signal of the POU transcription factor Skn-1a in epidermal keratinocytes

Ryuta Moritsugu et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2014)

Add to Collection

Review Genetics & Heredity

Mutations in regulators of the epigenome and their connections to global chromatin patterns in cancer

Christoph Plass et al.

NATURE REVIEWS GENETICS (2013)

Add to Collection

Correction Biochemistry & Molecular Biology

Gene expression profiling identifies molecular subtypes of gliomas (vol 22, pg 4918, 2003)

R. Shai et al.

ONCOGENE (2006)

Add to Collection

Article Oncology

Gene expression profiling identifies molecular subtypes of inflammatory breast cancer

F Bertucci et al.

CANCER RESEARCH (2005)

Add to Collection

Article Biochemistry & Molecular Biology

Oct-2 regulates CD36 gene expression via a consensus octamer, which excludes the co-activator OBF-1

P Shore et al.

NUCLEIC ACIDS RESEARCH (2002)

Add to Collection

© Peeref 2019-2024. All rights reserved.