Journal
NATURE MICROBIOLOGY
Volume 7, Issue 11, Pages 1756-+Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41564-022-01246-1
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Funding
- Singapore National Research Foundation [NRF2016NRF-NSFC002-013, NRF2018NRF-NSFC003SB-002]
- National Medical Research Council [STPRG-FY19-001, COVID19RF-003, COVID19RF-060, MOH-000535/MOH-OFYIRG19nov-0002, OFLCG19May-0034]
- Faculty of Medicine, Chulalongkorn University [RA(PO)002/64]
- King Chulalongkorn Memorial Hospital Fund for research [HA-64-3300-21-024]
- Biobank, Faculty of Medicine, Chulalongkorn University
- Bill and Melinda Gates award [INV-018944]
- National Institutes of Health [R01 AI138546]
- South African Medical Research Council [6084-CO-AP-2020]
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The study found that the Omicron variant of SARS-CoV-2 can escape neutralizing antibodies against the ancestral virus. Bat and pangolin sarbecoviruses showed less neutralization escape compared to the Omicron variant. This suggests that SARS-CoV-2 variants are evolving differently from animal sarbecoviruses under immune selection pressure.
The SARS-CoV-2 Omicron variant (B.1.1.529 lineage) escapes antibodies that neutralize the ancestral virus. We tested human serum panels from participants with differing infection and vaccination status using a multiplex surrogate virus neutralization assay targeting 20 sarbecoviruses. We found that bat and pangolin sarbecoviruses showed significantly less neutralization escape than the Omicron variant. We propose that SARS-CoV-2 variants have emerged under immune selection pressure and are evolving differently from animal sarbecoviruses.
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