Journal
CHEMISTRYSELECT
Volume 7, Issue 38, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.202203291
Keywords
Antibacterial effects; Deep eutectic solvent; Green synthesis; Pellizzari-type reactions; 1; 2; 4-Triazole
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Funding
- University of Zabol [UOZ-GR-4711]
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A new one-pot method for the synthesis of 3-amino-1,2,4-triazole derivatives was proposed using choline chloride/urea as a solvent and reagent. This method has the advantages of being eco-friendly, low-cost, and efficient, and the synthesized triazoles showed antimicrobial activity against various bacterial strains.
In this study, a new one-pot method was proposed for the synthesis of novel and known 3-amino-1,2,4-triazole derivatives in choline chloride/urea (1 : 2) as a biodegradable, nontoxic, biorenewable and inexpensive solvent and reagent. It efficiently catalyzed the reaction between alkyl/aryl hydrazides with urea. Some of the advantages of the proposed method are: eco-friendly and low-cost procedure, easy work-up and purification, good to excellent product yields and acceptable reaction times. This method can be a model for Pellizzari-type reactions. Antimicrobial activity of the synthesized 1,2,4-triazoles were evaluated against five Gram-positive and three Gram-negative pathogenic bacteria via Kirby-Bauer disk diffusion method. Triazoles containing 3-bromophenyl and 4-(tert-butyl)phenyl substituents were the most effective antibacterial agents against all tested bacterial strains.
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