DCC Mediated Direct Amidation of NSAID Naproxen, Ibuprofen and Ketoprofen with Secondary Amines

Direct and atom-economical amidation of nonsteroidal anti-inflammatory drugs naproxen ibuprofen and ketoprofen with a variety of secondary amines was effected using commercially available DCC under mild and open-air conditions. These prodrug amides were obtained in good to moderate yields ranging between 30-90 %.

Automated summary

A direct and atom-economic method was developed to accomplish the amidation of nonsteroidal anti-inflammatory drugs naproxen, ibuprofen and ketoprofen with various secondary amines using commercially available DCC under mild and open-air conditions. The prodrug amides were obtained with good to moderate yields ranging between 30-90%.