4.6 Article

Decreased resting-state neural signal in the left angular gyrus as a potential neuroimaging biomarker of schizophrenia: An amplitude of low-frequency fluctuation and support vector machine analysis

Related references

Note: Only part of the references are listed.
Article Neurosciences

Efficient optimization based thresholding technique for analysis of alzheimer MRIs

S. Prabha et al.

Summary: This study proposes an optimization-based segmentation technique to extract GM and WM tissues in patients with Alzheimer's disease. By classifying and calculating features from MRI images, using a support vector machine classifier. The results show that this optimization algorithm is more effective compared to other methods, assisting in the diagnosis and assessment of Alzheimer's disease.

INTERNATIONAL JOURNAL OF NEUROSCIENCE (2023)

Article Psychology, Clinical

Effects of polygenic risk of schizophrenia on interhemispheric callosal white matter integrity and frontotemporal functional connectivity in first-episode schizophrenia

Wenjun Su et al.

Summary: Schizophrenia is a severe psychiatric disorder with high heritability and polygenic architecture. Higher polygenic risk scores are associated with smaller grey matter volume, lower activation, and decreased functional connectivity in the brain. Additionally, higher polygenic risk scores are linked with disrupted white matter integrity and functional connectivity in patients with schizophrenia, particularly affecting the connections between frontotemporal regions.

PSYCHOLOGICAL MEDICINE (2023)

Article Psychology, Clinical

Shared and specific patterns of dynamic functional connectivity variability of striato-cortical circuitry in unmedicated bipolar and major depressive disorders

Guanmao Chen et al.

Summary: This study investigated the shared and specific patterns of dynamic functional connectivity (dFC) variability of the striato-cortical circuitry in bipolar disorder (BD) and major depressive disorder (MDD). The results showed that both BD and MDD patients had common dFC alterations in the dorsal striatal-sensorimotor and ventral striatal-cognitive circuitries, while MDD patients had specific dFC alterations in the ventral striatal-affective circuitry.

PSYCHOLOGICAL MEDICINE (2022)

Article Rheumatology

The effects of disease activity on neuronal and behavioural cognitive processes in systemic lupus erythematosus

Michelle Barraclough et al.

Summary: This study aimed to explore the effects of disease activity in systemic lupus erythematosus (SLE) on cognitive function while considering other potential mediators. The results showed that disease activity affected functional brain processes but had no impact on cognitive behavioral measures. Flaring SLE patients were found to have difficulty suppressing specific brain regions during a working memory task, which may lead to cognitive fatigue.

RHEUMATOLOGY (2022)

Article Psychiatry

(Attenuated) hallucinations join basic symptoms in a transdiagnostic network cluster analysis

Natalia Jimeno et al.

Summary: Hallucinations are characteristic symptoms of psychosis, but it is important to distinguish true psychotic hallucinations from other hallucinatory experiences. Network analysis of different symptoms revealed three clusters, and it was concluded that attenuated hallucinations should not be used to diagnose psychosis.

SCHIZOPHRENIA RESEARCH (2022)

Article Geriatrics & Gerontology

Abnormal Default Mode Network Homogeneity in Major Depressive Disorder With Gastrointestinal Symptoms at Rest

Meiqi Yan et al.

Summary: This study found that patients with major depressive disorder (MDD) who have gastrointestinal (GI) symptoms experience more severe depressive symptoms compared to those without GI symptoms. Distinct patterns in the default mode network (DMN) were also observed in MDD patients with GI symptoms, which can potentially serve as a brain imaging marker for differentiating patients with GI symptoms from those without GI symptoms.

FRONTIERS IN AGING NEUROSCIENCE (2022)

Article Medicine, General & Internal

Large-scale network dysfunction in a-Synucleinopathy: A meta-analysis of resting-state functional connectivity

Shi Tang et al.

Summary: A meta-analysis on network dysfunction in patients with alpha-Synucleinopathy revealed imbalanced connectivity in subcortical networks, cerebellum, and frontal networks related to motor functioning and cognitive control. Patients also exhibited hypoconnectivity in networks involved in cognition and attention, as well as abnormal connectivity between networks related to emotion regulation and processing.

EBIOMEDICINE (2022)

Article Clinical Neurology

Abnormal spontaneous neural activity as a potential predictor of early treatment response in patients with obsessive-compulsive disorder

Haohao Yan et al.

Summary: This study aimed to explore the value of early improvement in OCD patients after treatment with paroxetine and analyze potential imaging changes. The study found abnormal brain activities in OCD patients at baseline, and significantly decreased fALFF in the left precuneus after treatment. By analyzing fALFF, diagnostic models can be built and treatment response can be predicted.

JOURNAL OF AFFECTIVE DISORDERS (2022)

Article Neuroimaging

Anatomy and white-matter connections of the precuneus

Onur Tanglay et al.

Summary: The precuneus is a heterogeneous cortical region with five major types of connections present bilaterally. Short association fibers connect the gyri of the precuneus and to other brain regions, cingulum bundle parts connect to frontal and temporal lobes, middle longitudinal fasciculus connects to temporal regions, parietopontine fibers connect to pontine regions, and a commissural bundle connects the precuneus bilaterally.

BRAIN IMAGING AND BEHAVIOR (2022)

Article Chemistry, Multidisciplinary

Ratiometric 3D DNA Machine Combined with Machine Learning Algorithm for Ultrasensitive and High-Precision Screening of Early Urinary Diseases

Na Wu et al.

Summary: The study demonstrates a diagnosis protocol for ultrasensitive detection of uEVs and accurate classification of early urinary diseases by combining a ratiometric 3D DNA machine with machine learning. The biosensor offers a detection limit of 9.9 X 10(3) particles mL(-1) for uEVs and achieves high diagnostic accuracy using K-nearest neighbor and support vector machine algorithms. The protocol also provides 100% accurate visual identification of clinical uEV samples using a t-distributed stochastic neighbor embedding algorithm.

ACS NANO (2021)

Article Psychiatry

Comparison of resting-state spontaneous brain activity between treatment-naive schizophrenia and obsessive-compulsive disorder

Xiao-Man Yu et al.

Summary: Results showed that OCD patients had increased ALFF in certain brain regions compared to SZ patients and healthy controls, while SZ patients had higher DC in certain brain regions compared to HC. Additionally, there were correlations between brain activity and symptom severity in both SZ and OCD groups. The study suggests that SZ and OCD have similarities in some brain activity patterns but also exhibit distinct patterns in specific brain regions.

BMC PSYCHIATRY (2021)

Article Clinical Neurology

Altered resting-state functional connectivity of the right precuneus and cognition between depressed and non-depressed schizophrenia

Pingping Li et al.

Summary: The study found that the cognitive function of patients with depressed and non-depressed schizophrenia was worse compared to healthy controls, with no significant difference between the two subtypes. Patients with depressed schizophrenia showed poorer resting-state functional connectivity compared to non-depressed patients, and these connectivity changes correlated with different cognitive domains.

PSYCHIATRY RESEARCH-NEUROIMAGING (2021)

Article Clinical Neurology

Characterizing the subtype of anhedonia in major depressive disorder: A symptom-specific multimodal MRI study

Xiaodan Liu et al.

Summary: The study revealed distinct pathophysiological bases and imaging characteristics between anticipatory anhedonia and consummatory anhedonia in drug-naive MDD patients. Elevated ALFF in the left dorsal anterior cingulate cortex (dACC) was associated with anticipatory anhedonia, while reduced cortical thickness (CT) in the left rostral ACC and lateral orbitofrontal cortex (lOFC) was associated with consummatory anhedonia.

PSYCHIATRY RESEARCH-NEUROIMAGING (2021)

Article Biochemistry & Molecular Biology

Brain dysfunction of methamphetamine-associated psychosis in resting state: Approaching schizophrenia and critical role of right superior temporal deficit

Mei Yang et al.

Summary: The study compared brain functions between patients with Methamphetamine-associated psychosis (MAP) and schizophrenia during resting state, finding a common trend of brain alteration between the two disorders with more pronounced dysfunction in schizophrenia. A critical role of the right superior temporal gyrus deficit was observed in the association between Methamphetamine use and psychosis, indicating a potential target for interventions.

ADDICTION BIOLOGY (2021)

Article Biochemistry & Molecular Biology

Decreased left amygdala functional connectivity by cognitive-coping therapy in obsessive-compulsive disorder

Zongya Zhao et al.

Summary: This study found that both pCCT and CCT significantly reduced LA-FC in OCD patients, indicating that FCs play a role in OCD. Decreased LA-FC with the ACC or paracentral/parietal cortex may be a marker for pCCT response or for distinguishing OCD subtypes. Decreased LA-FC with the parietal region may be a common pathway for pCCT and CCT.

MOLECULAR PSYCHIATRY (2021)

Article Psychiatry

Changes in Default-Mode Network Associated With Childhood Trauma in Schizophrenia

Maria R. Dauvermann et al.

Summary: The study found widespread reductions in functional connectivity in patients with schizophrenia, including between left/right parietal lobes and other regions. Increased scores of childhood trauma were associated with reduced prefrontal-parietal connectivity and increased prefrontal-cerebellar connectivity in patients, which also predicted variation in behavioral measures of Theory of Mind.

SCHIZOPHRENIA BULLETIN (2021)

Article Psychiatry

Neuroanatomical correlates of reality monitoring in patients with schizophrenia and auditory hallucinations

Melanie Perret et al.

Summary: Impaired reality-monitoring abilities in schizophrenia patients with auditory hallucinations are associated with shorter right paracingulate sulcus and reduced gray-matter volume in temporal and parietal regions. Auditory hallucinations may affect this relationship.

EUROPEAN PSYCHIATRY (2021)

Review Clinical Neurology

Large-scale network abnormality in bipolar disorder: A multimodal meta-analysis of resting-state functional and structural magnetic resonance imaging studies

Jiaying Gong et al.

Summary: This study aimed to systematically compare brain connectivity and morphological differences in individuals with bipolar disorder and healthy controls. The results showed that patients with bipolar disorder exhibited either increased or decreased functional connectivity in brain networks, accompanied by changes in gray matter volume.

JOURNAL OF AFFECTIVE DISORDERS (2021)

Article Psychiatry

Absence of negative associations of insular and medial frontal gray matter volume with dissociative symptoms in schizophrenia

Huai-Hsuan Tseng et al.

Summary: This study identified complex interactions among dissociative symptoms, traumatic experiences, and brain volume in schizophrenia patients. Pathological dissociation was found to be related to specific brain volume changes, highlighting the importance of understanding the pathophysiological mechanisms of schizophrenia.

JOURNAL OF PSYCHIATRIC RESEARCH (2021)

Article Psychiatry

Fronto-parietal network function during cued visual search in the first-episode schizophrenia spectrum

Alfredo L. Sklar et al.

Summary: Cognitive impairments play a significant role in schizophrenia and are present at disease onset. Patients with first-episode schizophrenia spectrum exhibit greater right hemisphere brain activity despite worse performance compared to healthy controls. Stronger activity in specific brain regions is associated with faster responses, reduced negative symptoms, and improved community functioning in patients.

JOURNAL OF PSYCHIATRIC RESEARCH (2021)

Article Psychiatry

Reduced resting state functional connectivity in the hippocampus-midbrain-striatum network of schizophrenia patients

Shiral S. Gangadin et al.

Summary: Contemporary preclinical models suggest that abnormal functioning of a brain network involving the hippocampus, midbrain, and striatum is critical in schizophrenia. This study found that schizophrenia patients have lower functional connectivity in this network, particularly between the SUB and LS, and VTA and AS. Functioning of the hippocampus-midbrain-striatum network is significantly altered in the pathophysiology of schizophrenia.

JOURNAL OF PSYCHIATRIC RESEARCH (2021)

Article Neurosciences

Abnormal interhemispheric resting state functional connectivity in Parkinson's disease patients with impulse control disorders

Caiting Gan et al.

Summary: Impulse control disorders in Parkinson's disease may be related to misjudgment of rewards and inability to suppress inappropriate choices. Our study found significant asymmetry in functional connectivity in specific brain regions among PD patients with impulse control disorders, which are associated with reward processing and inhibitory control.

NPJ PARKINSONS DISEASE (2021)

Article Genetics & Heredity

Region-specific insular volumetric decreases in drug-naive, first-episode schizophrenia and their unaffected siblings

Huabing Li et al.

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS (2020)

Article Biochemistry & Molecular Biology

A neuroimaging biomarker for striatal dysfunction in schizophrenia

Ang Li et al.

NATURE MEDICINE (2020)

Article Neurosciences

Beyond the disconnectivity hypothesis of schizophrenia

Edmund T. Rolls et al.

CEREBRAL CORTEX (2020)

Article Clinical Neurology

Resting-state anticorrelated networks in Schizophrenia

Shukti Ramkiran et al.

PSYCHIATRY RESEARCH-NEUROIMAGING (2019)

Review Neurosciences

A Review of the Functional and Anatomical Default Mode Network in Schizophrenia

Mao-Lin Hu et al.

NEUROSCIENCE BULLETIN (2017)

Article Psychiatry

Hippocampal volume in first-episode schizophrenia and longitudinal course of the illness

Martin Hyza et al.

WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY (2016)

Review Neurosciences

The Brain's Default Mode Network

Marcus E. Raichle

ANNUAL REVIEW OF NEUROSCIENCE, VOL 38 (2015)

Review Psychiatry

Definition and description of schizophrenia in the DSM-5

Rajiv Tandon et al.

SCHIZOPHRENIA RESEARCH (2013)

Article Computer Science, Artificial Intelligence

LIBSVM: A Library for Support Vector Machines

Chih-Chung Chang et al.

ACM TRANSACTIONS ON INTELLIGENT SYSTEMS AND TECHNOLOGY (2011)

Article Psychiatry

Abnormal angular gyrus asymmetry in schizophrenia

M Niznikiewicz et al.

AMERICAN JOURNAL OF PSYCHIATRY (2000)