4.6 Review

Advances in optogenetic studies of depressive-like behaviors and underlying neural circuit mechanisms

Related references

Note: Only part of the references are listed.
Article Neurosciences

Glucocorticoid Receptor-Dependent Astrocytes Mediate Stress Vulnerability

Cheng-Lin Lu et al.

Summary: Astrocytic glucocorticoid receptors (GRs) play a crucial role in stress response, and reduced expression of GRs in astrocytes leads to stress vulnerability. GRs in astrocytes are more sensitive to stress compared to those in neurons.

BIOLOGICAL PSYCHIATRY (2022)

Article Neurosciences

Optogenetic stimulation of lateral hypothalamic orexin/dynorphin inputs in the ventral tegmental area potentiates mesolimbic dopamine neurotransmission and promotes reward-seeking behaviours

Catherine S. Thomas et al.

Summary: Reward and reinforcement processes are critical for survival and propagation of genes, with mesolimbic dopamine playing a central role. Optogenetic stimulation of orexin/dynorphin inputs in the VTA potentiates dopamine release in the NAc core, resulting in real time and conditioned place preference as well as increased food cue-directed orientation. While dynorphin contributes to aversive conditioning, the rewarding effects of LH orexin/dynorphin stimulation in the VTA are primarily driven by orexin rather than dynorphin.

NEUROPSYCHOPHARMACOLOGY (2022)

Article Biochemistry & Molecular Biology

Article Ingested non-essential amino acids recruit brain orexin cells to suppress eating in mice

Paulius Viskaitis et al.

Summary: Ingested non-essential amino acids activate hypothalamic orexin/hypocretin neurons and shift behavior from eating to exploration. This effect is independent of the gut/brain communication pathway. The study also suggests that the reduction in food intake caused by non-essential amino acids is related to the modulation of food palatability.

CURRENT BIOLOGY (2022)

Article Biology

A discrete parasubthalamic nucleus subpopulation plays a critical role in appetite suppression

Jessica H. Kim et al.

Summary: Food intake behavior is regulated by a network of neuronal populations in the brain. The study identifies two subpopulations, PSTNTac1 and PSTNCRH, in the parasubthalamic nucleus (PSTN), which play different roles in appetite suppression. PSTNTac1 neurons reduce appetite by transmitting signals, while PSTNCRH neurons do not have this effect.

ELIFE (2022)

Review Neurosciences

Optogenetic and chemogenetic insights into the neurocircuitry of depression-like behaviour: A systematic review

Tom Biselli et al.

Summary: Major depressive disorder (MDD) and its treatment pose global health challenges. Optogenetics and chemogenetics have advanced MDD research by uncovering causal relationships between cell-type-specific control of neurons and depressive-like behavior in rodents.

EUROPEAN JOURNAL OF NEUROSCIENCE (2021)

Article Psychiatry

AgRP neurons trigger long-term potentiation and facilitate food seeking

Chunmei Wang et al.

Summary: Sufficient feeding is essential for animals' survival, and the neurobiological processes regulating food seeking behavior have been partially understood, in which the AgRP -> PVT circuit is crucial for food seeking.

TRANSLATIONAL PSYCHIATRY (2021)

Article Clinical Neurology

Insufficiency of ventral hippocampus to medial prefrontal cortex transmission explains antidepressant non-response

Mariusz Papp et al.

Summary: The study investigated the synergistic effects of chronic Venlafaxine and repeated optogenetic stimulation on antidepressant non-responsive rats, and found that the combination was effective in restoring normal behavior. While vHPC-mPFC OGS with VEN treatment supported the hypothesis of antidepressant non-responsiveness, dHPC-mPFC OGS alone was effective in improving behavior in the EPM and NOR tests.

JOURNAL OF PSYCHOPHARMACOLOGY (2021)

Article Cell Biology

Functional heterogeneity of POMC neurons relies on mTORC1 signaling

Nicolas Saucisse et al.

Summary: Blocking the energy sensor mTORC1 in POMC neurons can mimic a cellular negative energy state, leading to hyperphagia. The functional specificity of the GABA and glutamate subpopulations in POMC neurons relies on the activity of mTORC1.

CELL REPORTS (2021)

Review Medicine, General & Internal

The PRISMA 2020 statement: an updated guideline for reporting systematic reviews

Matthew J. Page et al.

Summary: The PRISMA statement was designed to help systematic reviewers transparently report the purpose, methods, and findings of their reviews. The updated PRISMA 2020 statement includes new reporting guidance, a 27-item checklist, an abstract checklist, and revised flow diagrams for reviews.

BMJ-BRITISH MEDICAL JOURNAL (2021)

Article Neurosciences

Dopaminergic Projection from Ventral Tegmental Area to Substantia Nigra Pars Reticulata Mediates Chronic Social Defeat Stress-Induced Hypolocomotion

Feng He et al.

Summary: The study found that chronic social defeat stress (CSDS) can affect the spontaneous locomotor activity of mice, but not their grip strength and forced locomotion ability.

MOLECULAR NEUROBIOLOGY (2021)

Article Clinical Neurology

Altered neural activity in the reward-related circuit and executive control network associated with amelioration of anhedonia in major depressive disorder by electroconvulsive therapy

Ting Zhang et al.

Summary: This study investigated the intrinsic brain functional alterations in patients with major depressive disorder before and after ECT, and found increased ALFF and DC in regions such as the bilateral dorsal medial prefrontal cortex. The results suggest that the amelioration of anhedonia following ECT may be related to changes in neural activity in the reward-related circuit and executive control network.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2021)

Article Endocrinology & Metabolism

MCH Neuron Activity Is Sufficient for Reward and Reinforces Feeding

Pelin Dilsiz et al.

NEUROENDOCRINOLOGY (2020)

Review Psychology

Depression's Unholy Trinity: Dysregulated Stress, Immunity, and the Microbiome

Joana S. Cruz-Pereira et al.

ANNUAL REVIEW OF PSYCHOLOGY, VOL 71 (2020)

Review Biochemistry & Molecular Biology

New era of optogenetics: from the central to peripheral nervous system

Xiang Xu et al.

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY (2020)

Review Biochemistry & Molecular Biology

Prefrontal cortex circuits in depression and anxiety: contribution of discrete neuronal populations and target regions

Brendan D. Hare et al.

MOLECULAR PSYCHIATRY (2020)

Article Neurosciences

Nesfatin-1 decreases the motivational and rewarding value of food

Riccardo Dore et al.

NEUROPSYCHOPHARMACOLOGY (2020)

Article Cell Biology

Social Behavior Is Modulated by Valence-Encoding mPFC-Amygdala Sub-circuitry

Wen-Chin Huang et al.

CELL REPORTS (2020)

Article Neurosciences

Activation of the ARCPOMC→MeA Projection Reduces Food Intake

Eunjin Kwon et al.

FRONTIERS IN NEURAL CIRCUITS (2020)

Meeting Abstract Clinical Neurology

Patients with major depressive disorder have lower cerebral serotonin 4 receptor binding than healthy controls

K. Koehler-Forsberg et al.

EUROPEAN NEUROPSYCHOPHARMACOLOGY (2020)

Review Clinical Neurology

Circuit Mechanisms of Reward, Anhedonia, and Depression

Anna Hoflich et al.

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2019)

Article Multidisciplinary Sciences

Ventral tegmental area astrocytes orchestrate avoidance and approach behavior

J. A. Gomez et al.

NATURE COMMUNICATIONS (2019)

Article Multidisciplinary Sciences

Unifying photocycle model for light adaptation and temporal evolution of cation conductance in channelrhodopsin-2

Jens Kuhne et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Neurosciences

Thermal constraints on in vivo optogenetic manipulations

Scott F. Owen et al.

NATURE NEUROSCIENCE (2019)

Article Neurosciences

A neural circuit for comorbid depressive symptoms in chronic pain

Wenjie Zhou et al.

NATURE NEUROSCIENCE (2019)

Article Behavioral Sciences

Anhedonia in depression symptomatology: Appetite dysregulation and defective brain reward processing

Roberto Coccurello

BEHAVIOURAL BRAIN RESEARCH (2019)

Review Clinical Neurology

Animal models of major depression: drawbacks and challenges

Barbara Planchez et al.

JOURNAL OF NEURAL TRANSMISSION (2019)

Article Multidisciplinary Sciences

Hierarchical organization of cortical and thalamic connectivity

Julie A. Harris et al.

NATURE (2019)

Review Neurosciences

The future of rodent models in depression research

Anand Gururajan et al.

NATURE REVIEWS NEUROSCIENCE (2019)

Article Multidisciplinary Sciences

Interacting neural ensembles in orbitofrontal cortex for social and feeding behaviour

Joshua H. Jennings et al.

NATURE (2019)

Article Multidisciplinary Sciences

Optogenetic stimulation of medial prefrontal cortex Drd1 neurons produces rapid and long-lasting antidepressant

Brendan D. Hare et al.

NATURE COMMUNICATIONS (2019)

Review Neurosciences

Next-Generation Tools to Study Autonomic Regulation In Vivo

Snigdha Mukerjee et al.

NEUROSCIENCE BULLETIN (2019)

Review Endocrinology & Metabolism

Regulation of Feeding-Related Behaviors by Arcuate Neuropeptide Y Neurons

Lei Zhang et al.

ENDOCRINOLOGY (2019)

Review Clinical Neurology

Anxiety, Depression, and the Microbiome: A Role for Gut Peptides

Gilliard Lach et al.

NEUROTHERAPEUTICS (2018)

Review Clinical Neurology

Neural basis of major depressive disorder: Beyond monoamine hypothesis

Shuken Boku et al.

PSYCHIATRY AND CLINICAL NEUROSCIENCES (2018)

Article Biochemistry & Molecular Biology

Astrocytic Activation Generates De Novo Neuronal Potentiation and Memory Enhancement

Adar Adamsky et al.

Article Neurosciences

Implantable, wireless device platforms for neuroscience research

Philipp Gutruf et al.

CURRENT OPINION IN NEUROBIOLOGY (2018)

Article Neurosciences

Brain Circuits Mediating Opposing Effects on Emotion and Pain

You-Qing Cai et al.

JOURNAL OF NEUROSCIENCE (2018)

Article Biochemistry & Molecular Biology

Stimulation of entorhinal cortex-dentate gyrus circuitry is antidepressive

Sanghee Yun et al.

NATURE MEDICINE (2018)

Review Behavioral Sciences

Treatment resistant depression: A multi-scale, systems biology approach

Huda Akil et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2018)

Article Multidisciplinary Sciences

A neural pathway controlling motivation to exert effort

Christophe D. Proulx et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Multidisciplinary Sciences

Targeted expression of step-function opsins in transgenic rats for optogenetic studies

Hiroyuki Igarashi et al.

SCIENTIFIC REPORTS (2018)

Article Multidisciplinary Sciences

Tailoring light delivery for optogenetics by modal demultiplexing in tapered optical fibers

Marco Pisanello et al.

SCIENTIFIC REPORTS (2018)

Article Biochemistry & Molecular Biology

Activation of temperature-sensitive TRPV1-like receptors in ARC POMC neurons reduces food intake

Jae Hoon Jeong et al.

PLOS BIOLOGY (2018)

Article Nanoscience & Nanotechnology

Flexible polyimide-based hybrid optoelectric neural interface with 16 channels of micro-LEDs and electrodes

Bowen Ji et al.

MICROSYSTEMS & NANOENGINEERING (2018)

Article Multidisciplinary Sciences

Mesopontine cholinergic inputs to midbrain dopamine neurons drive stress-induced depressive-like behaviors

Sebastian P. Fernandez et al.

NATURE COMMUNICATIONS (2018)

Review Neurosciences

Dysregulation of the Lateral Habenula in Major Depressive Disorder

Caroline A. Browne et al.

FRONTIERS IN SYNAPTIC NEUROSCIENCE (2018)

Review Neurosciences

Integration of optogenetics with complementary methodologies in systems neuroscience

Christina K. Kim et al.

NATURE REVIEWS NEUROSCIENCE (2017)

Review Clinical Neurology

Optogenetics: Applications in psychiatric research

Fukutoshi Shirai et al.

PSYCHIATRY AND CLINICAL NEUROSCIENCES (2017)

Article Multidisciplinary Sciences

Limiting habenular hyperactivity ameliorates maternal separation-driven depressive-like symptoms

Anna Tchenio et al.

NATURE COMMUNICATIONS (2017)

Article Biochemistry & Molecular Biology

Distinct Ventral Pallidal Neural Populations Mediate Separate Symptoms of Depression

Daniel Knowland et al.

Article Neurosciences

Optogenetic stimulation of astrocytes in the posterior hypothalamus increases sleep at night in C57BL/6J mice

Dheeraj Pelluru et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2016)

Article Multidisciplinary Sciences

Structural foundations of optogenetics: Determinants of channelrhodopsin ion selectivity

Andre Berndt et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Multidisciplinary Sciences

Prefrontal cortical regulation of brainwide circuit dynamics and reward-related behavior

Emily A. Ferenczi et al.

SCIENCE (2016)

Review Biochemistry & Molecular Biology

Dorsal Raphe Dopamine Neurons Represent the Experience of Social Isolation

Gillian A. Matthews et al.

Article Multidisciplinary Sciences

Target-specific modulation of the descending prefrontal cortex inputs to the dorsal raphe nucleus by cannabinoids

Sean D. Geddes et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Multidisciplinary Sciences

Activation of D2 dopamine receptor-expressing neurons in the nucleus accumbens increases motivation

Carina Soares-Cunha et al.

NATURE COMMUNICATIONS (2016)

Article Multidisciplinary Sciences

Ventral tegmental area glutamate neurons co-release GABA and promote positive reinforcement

Ji Hoon Yoo et al.

NATURE COMMUNICATIONS (2016)

Article Biochemistry & Molecular Biology

Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice

M. M. Sidor et al.

MOLECULAR PSYCHIATRY (2015)

Article Multidisciplinary Sciences

Activating positive memory engrams suppresses depression-like behaviour

Steve Ramirez et al.

NATURE (2015)

Article Neurosciences

Optogenetics: 10 years of microbial opsins in neuroscience

Karl Deisseroth

NATURE NEUROSCIENCE (2015)

Article Multidisciplinary Sciences

Optogenetic stimulation of infralimbic PFC reproduces ketamine's rapid and sustained antidepressant actions

Manabu Fuchikami et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Review Neurosciences

The ventral pallidum: Subregion-specific functional anatomy and roles in motivated behaviors

David H. Root et al.

PROGRESS IN NEUROBIOLOGY (2015)

Article Multidisciplinary Sciences

Refining deep brain stimulation to emulate optogenetic treatment of synaptic pathology

Meaghan Creed et al.

SCIENCE (2015)

Article Multidisciplinary Sciences

Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression

Rosemary C. Bagot et al.

NATURE COMMUNICATIONS (2015)

Article Multidisciplinary Sciences

Left brain cortical activity modulates stress effects on social behavior

Eunee Lee et al.

SCIENTIFIC REPORTS (2015)

Article Cell Biology

Activity of Raphe Serotonergic Neurons Controls Emotional Behaviors

Anne Teissier et al.

CELL REPORTS (2015)

Article Clinical Neurology

Dimensions in major depressive disorder and their relevance for treatment outcome

Elske Vrieze et al.

JOURNAL OF AFFECTIVE DISORDERS (2014)

Article Biochemical Research Methods

Targeting cells with single vectors using multiple-feature Boolean logic

Lief E. Fenno et al.

NATURE METHODS (2014)

Article Neurosciences

Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway

Jessica J. Walsh et al.

NATURE NEUROSCIENCE (2014)

Article Multidisciplinary Sciences

Enhancing Depression Mechanisms in Midbrain Dopamine Neurons Achieves Homeostatic Resilience

Allyson K. Friedman et al.

SCIENCE (2014)

Article Multidisciplinary Sciences

A glutamatergic reward input from the dorsal raphe to ventral tegmental area dopamine neurons

Jia Qi et al.

NATURE COMMUNICATIONS (2014)

Review Clinical Neurology

Update of sleep alterations in depression

Andres Barrera Medina et al.

SLEEP SCIENCE (2014)

Article Psychology, Clinical

Interpersonal Processes in Depression

Jennifer L. Hames et al.

ANNUAL REVIEW OF CLINICAL PSYCHOLOGY, VOL 9 (2013)

Article Medicine, Research & Experimental

Impaired periamygdaloid-cortex prodynorphin is characteristic of opiate addiction and depression

Sarah Ann R. Anderson et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Article Multidisciplinary Sciences

Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons

Dipesh Chaudhury et al.

NATURE (2013)

Article Multidisciplinary Sciences

Genetic identification of a neural circuit that suppresses appetite

Matthew E. Carter et al.

NATURE (2013)

Review Neurosciences

The brain reward circuitry in mood disorders

Scott J. Russo et al.

NATURE REVIEWS NEUROSCIENCE (2013)

Article Psychology, Developmental

Anhedonia Predicts Poorer Recovery Among Youth With Selective Serotonin Reuptake Inhibitor Treatment-Resistant Depression

Dana L. McMakin et al.

JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY (2012)

Editorial Material Clinical Neurology

Twenty-five years of deep brain stimulation: Celebrations and apprehensions

Marwan Hariz

MOVEMENT DISORDERS (2012)

Article Multidisciplinary Sciences

Deciphering a neuronal circuit that mediates appetite

Qi Wu et al.

NATURE (2012)

Article Multidisciplinary Sciences

Input-specific control of reward and aversion in the ventral tegmental area

Stephan Lammel et al.

NATURE (2012)

Article Neurosciences

Activation of VTA GABA Neurons Disrupts Reward Consumption

Ruud van Zessen et al.

NEURON (2012)

Article Neurosciences

Whole-Brain Mapping of Direct Inputs to Midbrain Dopamine Neurons

Mitsuko Watabe-Uchida et al.

NEURON (2012)

Article Psychiatry

Deep Brain Stimulation for Treatment-Resistant Depression: Follow-Up After 3 to 6 Years

Sidney H. Kennedy et al.

AMERICAN JOURNAL OF PSYCHIATRY (2011)

Review Neurosciences

The Development and Application of Optogenetics

Lief Fenno et al.

ANNUAL REVIEW OF NEUROSCIENCE, VOL 34 (2011)

Review Pharmacology & Pharmacy

GABAergic signaling by AgRP neurons prevents anorexia via a melanocortin-independent mechanism

Qi Wu et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2011)

Article Biochemical Research Methods

Optogenetics

Karl Deisseroth

NATURE METHODS (2011)

Article Neurosciences

Antidepressant Effect of Optogenetic Stimulation of the Medial Prefrontal Cortex

Herbert E. Covington et al.

JOURNAL OF NEUROSCIENCE (2010)

Article Neurosciences

Ultrafast optogenetic control

Lisa A. Gunaydin et al.

NATURE NEUROSCIENCE (2010)

Review Neurosciences

Are the Dorsal and Ventral Hippocampus Functionally Distinct Structures?

Michael S. Fanselow et al.

NEURON (2010)

Review Medicine, Research & Experimental

Targeted electrode-based modulation of neural circuits for depression

Helen S. Mayberg

JOURNAL OF CLINICAL INVESTIGATION (2009)

Article Multidisciplinary Sciences

Phasic Firing in Dopaminergic Neurons Is Sufficient for Behavioral Conditioning

Hsing-Chen Tsai et al.

SCIENCE (2009)

Article Multidisciplinary Sciences

The molecular neurobiology of depression

Vaishnav Krishnan et al.

NATURE (2008)

Review Psychiatry

The role of dopamine in the pathophysiology of depression

Boadie W. Dunlop et al.

ARCHIVES OF GENERAL PSYCHIATRY (2007)

Article Neurosciences

Millisecond-timescale, genetically targeted optical control of neural activity

ES Boyden et al.

NATURE NEUROSCIENCE (2005)

Review Neurosciences

Dopamine, learning and motivation

RA Wise

NATURE REVIEWS NEUROSCIENCE (2004)