Journal
FRONTIERS IN ENDOCRINOLOGY
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fendo.2022.1017387
Keywords
peridroplet mitochondria; lipid droplets; diabetic nephropathy; mitochondria; beta-oxidation
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Funding
- National Natural Science Foundation of China
- [81900069]
- [82000697]
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This review summarizes the molecular mechanisms of renal lipid deposition in diabetic nephropathy and discusses the potential of peridroplet mitochondria as a therapeutic target.
Diabetic nephropathy (DN) involves serious lipid metabolism disorder, and renal ectopic lipid deposition aggravates DN progression. However, the molecular mechanism of renal lipid deposition in DN remains unclear. Lipid droplets (LDs) are lipid pools in cells that change dynamically in response to the cellular energy needs. The LDs and mitochondria are connected through a part of the mitochondria known as the peridroplet mitochondria (PDM). In this review, we summarize the definition, detection methods, and function of the PDM. Finally, we discuss the research status of PDM in DN and the possibility of its use as a therapeutic target.
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