Journal
FRONTIERS IN ENDOCRINOLOGY
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fendo.2022.973058
Keywords
protein kinase C; diabetes mellitus; diabetic microvascular complications; microvascular; review
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Funding
- National Natural Science Foundation of China [81904025, 82104907]
- Fundamental Research Funds for the Central public welfare research institutes Grant [ZZ13-YQ-016, ZZ13-YQ-016-C1]
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Protein kinase C (PKC) plays a crucial role in the development of diabetic microvascular complications by becoming activated under high-glucose conditions, leading to the accumulation of redox stress. This activation affects various types of cells in the microvasculature, resulting in changes in blood flow, microvascular permeability, extracellular matrix accumulation, basement thickening, and angiogenesis.
Protein kinase C (PKC) is a family of serine/threonine protein kinases, the activation of which plays an important role in the development of diabetic microvascular complications. The activation of PKC under high-glucose conditions stimulates redox reactions and leads to an accumulation of redox stress. As a result, various types of cells in the microvasculature are influenced, leading to changes in blood flow, microvascular permeability, extracellular matrix accumulation, basement thickening and angiogenesis. Structural and functional disorders further exacerbate diabetic microvascular complications. Here, we review the roles of PKC in the development of diabetic microvascular complications, presenting evidence from experiments and clinical trials.
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