Journal
FRONTIERS IN ENDOCRINOLOGY
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fendo.2022.1042511
Keywords
leptin; experimental autoimmune thyroiditis (EAT); JAK2; STAT3 pathway; leptin receptor antagonist; NOD; ShiLtJ mouse
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Funding
- National Natural Science Foundation of China [82070288]
- Science & Technology Department of Sichuan Province [22ZDYF3805]
- Health Commission of Sichuan Province [21PJ100]
- Office of Science and Technology and Intellectual Property of Luzhou [22YYJC0088]
- Talent Development Project of The Affiliated Hospital of Southwest Medical University [20062]
- Affiliated Stomatological Hospital of Southwest Medical University [2022Y02]
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Allo-aca has been shown to reduce thyroid injury in EAT mice by altering the differentiation of Treg/Th17 cells, providing a novel approach to treating and ameliorating Hashimoto's thyroiditis.
Leptin has been found to be involved in the development and progression of many autoimmune diseases. As an organ-specific autoimmune disease, the pathogenesis of Hashimoto's thyroiditis has not been fully elucidated. It has been reported that serum leptin level is increased in Hashimoto's thyroiditis, but other studies have not shown any difference. We replicated a mouse model of experimental autoimmune thyroiditis (EAT) with a high-iodine diet and found that injection of the leptin receptor antagonist Allo-aca reduced thyroid follicle destruction and inflammatory cell infiltration in EAT mice, and thyroxine and thyroid autoimmune antibody levels. Further investigation revealed that Allo-aca promotes the differentiation of Treg cells and inhibits the differentiation of Th17 cells. We believe that Allo-aca can alter the differentiation of Treg/Th17 cells by inhibiting the leptin signaling pathway, thereby alleviating thyroid injury in EAT mice. Interfering with the leptin signaling pathway may be a novel new approach to treat treating and ameliorating Hashimoto's thyroiditis.
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