4.7 Article

Free, bioavailable 25-hydroxyvitamin D levels and their association with diabetic ketoacidosis in children with type 1 diabetes at diagnosis

Journal

FRONTIERS IN ENDOCRINOLOGY
Volume 13, Issue -, Pages -

Publisher

FRONTIERS MEDIA SA
DOI: 10.3389/fendo.2022.997631

Keywords

diabetes mellitus type 1; pediatrics; diabetic ketoacidosis (DKA); 25-hydroxyvitamin D (25OHD); vitamin D-binding protein

Funding

  1. National Research Foundation of Korea (NRF) - Korea government (Ministry of Science and ICT)
  2. NRF
  3. Seoul National University Hospital Research Fund
  4. [2019R 1F 1A1058922]
  5. [04-2019-3060]

Ask authors/readers for more resources

It was found that T1DM patients had lower total 25OHD levels but higher free 25OHD levels. Patients with DKA had significantly lower bioavailable 25OHD levels at diagnosis.
BackgroundConsidering the roles of 25-hydroxyvitamin D (25OHD) in glucose homeostasis and immune modulation, vitamin D deficiency may be related to the development of type 1 diabetes (T1DM) and diabetic ketoacidosis (DKA). We evaluated the total, free, bioavailable 25OHD levels and vitamin D binding protein (VDBP) levels and genotypes between T1DM patients and controls. MethodsThis retrospective, cross-sectional study included 84 children with T1DM (38 boys and 46 girls, 8.0 +/- 3.6 years) and 1:1 age- and sex-matched healthy controls. A multiplex liquid chromatography-tandem mass spectrometry-based assay was used to simultaneously measure vitamin D metabolites. ResultsPatients with T1DM had lower levels of total 25OHD (16.3 +/- 5.1 vs. 19.9 +/- 6.5 ng/mL, P< 0.001) and VDBP (146.0 +/- 27.8 vs. 224.9 +/- 36.1 mu g/mL, P = 0.001), but higher free 25OHD (8.0 +/- 2.5 vs. 6.5 +/- 2.3 pg/mL, P< 0.001) than controls. Patients who presented with DKA had lower levels of 25OHD in the total (15.0 +/- 4.6 vs. 17.6 +/- 5.2 ng/mL, P = 0.020), free (7.5 +/- 2.6 vs. 8.4 +/- 2.4 pg/mL, P = 0.059), and bioavailable (2.3 +/- 0.9 vs. 2.8 +/- 0.8 ng/mL, P = 0.014) forms than those without DKA at the T1DM diagnosis. The lower the total, free, and bioavailable 25OHD levels at diagnosis, the lower the pH and HCO3-. The proportions of the VDBP genotypes did not differ between the patients and controls. ConclusionPatients with T1DM had higher levels of free 25OHD than healthy children, despite lower levels of total 25OHD. However, patients with DKA exhibited lower levels of bioavailable 25OHD than those without DKA at the T1DM diagnosis. The lower the concentrations of free and bioavailable 25OHD, the more severe the acidosis at the initial T1DM presentation.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available