4.7 Article

Hypoxia-driven metabolic reprogramming of adipocytes fuels cancer cell proliferation

Related references

Note: Only part of the references are listed.
Review Oncology

The adipocyte microenvironment and cancer

Abir Mukherjee et al.

Summary: Tumor cells interact with adipocytes to convert them into cancer-associated adipocytes, supporting tumor growth. Tumors can stimulate lipolysis in adipocytes and uptake of fatty acids for various cellular processes.

CANCER AND METASTASIS REVIEWS (2022)

Article Biochemistry & Molecular Biology

Adipocyte-derived exosomes may promote breast cancer progression in type 2 diabetes

Naser Jafari et al.

Summary: The study found that vesicles shed by adipocytes from type 2 diabetes patients or insulin-resistant individuals contain protein TSP5 that promotes EMT in breast cancer cells, potentially worsening the prognosis for breast cancer patients. Additionally, the gene expression in these vesicles can affect the prognosis of breast cancer patients.

SCIENCE SIGNALING (2021)

Review Biochemistry & Molecular Biology

Cancer-Associated Adipocytes in Breast Cancer: Causes and Consequences

Ilona Rybinska et al.

Summary: Breast cancer progression is heavily influenced by the interaction between tumor cells and cancer-associated adipocytes (CAAs), and understanding the molecular pathways related to adipocyte differentiation is crucial for devising new therapeutic interventions. Recent studies have highlighted the mechanisms through which CAAs impact breast cancer progression, including adipokine regulation, metabolic reprogramming, extracellular matrix remodeling, and immune cell modulation.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Oncology

Tumour fatty acid metabolism in the context of therapy resistance and obesity

Andrew J. Hoy et al.

Summary: This review discusses the mechanistic links between fatty acid metabolism in cancer cells and disease behavior and therapy resistance, emphasizing the importance of factors such as lipid synthesis, storage, and catabolism in supporting tumorigenesis and treatment resistance. The role of membrane fatty acid composition is increasingly appreciated for promoting cell survival and limiting lipotoxicity and ferroptosis, while tumor cells exhibit plasticity in response to metabolic signals, such as obesity and cancer therapeutics, to promote aggressive, treatment-resistant disease. The study also highlights the impact of obesity-associated changes in host fatty acid metabolism on the tumor microenvironment and cancer cell behavior.

NATURE REVIEWS CANCER (2021)

Review Multidisciplinary Sciences

Metabolic reprogramming and cancer progression

Brandon Faubert et al.

SCIENCE (2020)

Article Cell Biology

A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate

Wenshan Wang et al.

CELL METABOLISM (2019)

Article Cell Biology

Cancer Lipid Metabolism Confers Antiangiogenic Drug Resistance

Hideki Iwamoto et al.

CELL METABOLISM (2018)

Article Multidisciplinary Sciences

Targeting metastasis-initiating cells through the fatty acid receptor CD36

Gloria Pascual et al.

NATURE (2017)

Article Medicine, Research & Experimental

Mammary adipocytes stimulate breast cancer invasion through metabolic remodeling of tumor cells

Yuan Yuan Wang et al.

JCI INSIGHT (2017)

Review Oncology

The biology and function of fibroblasts in cancer

Raghu Kalluri

NATURE REVIEWS CANCER (2016)

Article Endocrinology & Metabolism

Adipocyte Pseudohypoxia Suppresses Lipolysis and Facilitates Benign Adipose Tissue Expansion

Zoi Michailidou et al.

DIABETES (2015)

Review Endocrinology & Metabolism

Obesity and cancer-mechanisms underlying tumour progression and recurrence

Jiyoung Park et al.

NATURE REVIEWS ENDOCRINOLOGY (2014)

Review Medicine, General & Internal

Tumour oxygenation: implications for breast cancer prognosis

H. Rundqvist et al.

JOURNAL OF INTERNAL MEDICINE (2013)

Article Multidisciplinary Sciences

Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids

Jurre J. Kamphorst et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Biochemistry & Molecular Biology

Mitochondrial stress causes increased succination of proteins in adipocytes in response to glucotoxicity

Norma Frizzell et al.

BIOCHEMICAL JOURNAL (2012)

Article Multidisciplinary Sciences

Hypoxic Conditions Induce a Cancer-Like Phenotype in Human Breast Epithelial Cells

Marica Vaapil et al.

PLOS ONE (2012)

Article Multidisciplinary Sciences

Dichotomous effects of VEGF-A on adipose tissue dysfunction

Kai Sun et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Multidisciplinary Sciences

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

Bin-Zhi Qian et al.

NATURE (2011)

Article Biochemistry & Molecular Biology

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

Kristin M. Nieman et al.

NATURE MEDICINE (2011)

Article Multidisciplinary Sciences

Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

Ralph J. DeBerardinis et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Multidisciplinary Sciences

Adipose-specific peroxisome proliferator-activated receptor γ knockout causes insulin resistance in fat and liver but not in muscle

WM He et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Review Oncology

Hypoxia - A key regulatory factor in tumour growth

AL Harris

NATURE REVIEWS CANCER (2002)

Article Biochemistry & Molecular Biology

Hypoxia inhibits G1/S transition through regulation of p27 expression

LB Gardner et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

Article Endocrinology & Metabolism

Characterization of a human preadipocyte cell strain with high capacity for adipose differentiation

M Wabitsch et al.

INTERNATIONAL JOURNAL OF OBESITY (2001)