☆ 4.6 Article

Identification and validation of a novel cellular senescence-related lncRNA prognostic signature for predicting immunotherapy response in stomach adenocarcinoma

FRONTIERS IN GENETICS (2022)

Related references

Note: Only part of the references are listed.

Review Oncology

Hallmarks of Cancer: New Dimensions

Douglas Hanahan

Summary: The concept of the hallmarks of cancer is a tool for simplifying the complexity of cancer phenotypes and genotypes into basic principles. This article proposes phenotypic plasticity and disrupted differentiation as distinct hallmark capabilities, and discusses nonmutational epigenetic reprogramming and polymorphic microbiomes as enabling characteristics. Additionally, the importance of senescent cells in the tumor microenvironment is highlighted. The integrative concept of the hallmarks of cancer helps in understanding the mechanisms of cancer development and applying that knowledge to cancer medicine.

CANCER DISCOVERY (2022)

Add to Collection

Article Immunology

Molecular Characteristics, Clinical Significance, and Cancer Immune Interactions of Angiogenesis-Associated Genes in Gastric Cancer

Xin Qing et al.

Summary: This study systematically assessed the association between angiogenesis and gastric cancer (GC). The authors identified two molecular subtypes and determined the correlation between angiogenesis-associated genes mutations, clinicopathological characteristics, prognosis, immune cell infiltration, and tumor microenvironment. They established an AAG_score for predicting overall survival (OS) and created a reliable nomogram for clinical viability. The study provides insights into the characteristics of TME and potential immunotherapy strategies in GC.

FRONTIERS IN IMMUNOLOGY (2022)

Add to Collection

Article Genetics & Heredity

Prognostic Ferroptosis-Related lncRNA Signatures Associated With Immunotherapy and Chemotherapy Responses in Patients With Stomach Cancer

Donlin Lai et al.

Summary: This study investigates the combined effects of ferroptosis and lncRNAs on the prognosis and therapy of stomach cancer. A prognostic model consisting of 10 ferroptosis-related lncRNAs was constructed and validated. The model had guiding significance for prognosis and personalized therapy, helping to identify stomach cancer patients who might benefit from immunotherapy and guiding the selection of personalized chemotherapeutic drugs. The study also revealed differences in immune response and sensitivity to certain chemotherapy drugs among different risk groups.

FRONTIERS IN GENETICS (2022)

Add to Collection

Article Genetics & Heredity

A Necroptosis-Related lncRNA-Based Signature to Predict Prognosis and Probe Molecular Characteristics of Stomach Adenocarcinoma

Lianghua Luo et al.

Summary: A 12-NRLs signature was developed to improve the prognosis prediction of STAD patients, with significant implications for clinical applications.

FRONTIERS IN GENETICS (2022)

Add to Collection

Article Medicine, General & Internal

Construction of a Prognostic Signature of 10 Autophagy-Related lncRNAs in Gastric Cancer

Wenwen Wang et al.

Summary: This study established a prognostic feature composed of 10 autophagy-related lncRNAs (ARlncs) for gastric cancer (GC) patients. The feature could predict the survival rate of patients and guide immunotherapies and precise treatments.

INTERNATIONAL JOURNAL OF GENERAL MEDICINE (2022)

Add to Collection

Article Biology

Identification of Autophagy- and Ferroptosis-Related lncRNAs Functioned through Immune-Related Pathways in Head and Neck Squamous Carcinoma

Qi Guo et al.

Summary: This study identifies specific long non-coding RNAs (lncRNAs) in head and neck squamous cell carcinoma (HNSC) patients that are significantly associated with patient prognosis, functioning through immune-related pathways. The findings contribute to understanding the interplay among autophagy, ferroptosis, and tumor immunity in HNSC, and may provide potential prognostic biomarkers and targets for tumor immunotherapy.

LIFE-BASEL (2021)

Add to Collection

Article Biochemistry & Molecular Biology

lncRNA ADAMTS9-AS1 promotes bladder cancer cell invasion, migration, and inhibits apoptosis and autophagy through PI3K/AKT/mTOR signaling pathway

Guoqing Yang et al.

Summary: The study revealed that the high expression of ADAMTS9-AS1 in bladder cancer promotes cell proliferation, migration, and invasion while reducing apoptosis and autophagy. It was also observed that ADAMTS9-AS1 may regulate these processes through the PI3K/AKT/mTOR signaling pathway. Targeting ADAMTS9-AS1 could be a potential therapeutic approach for treating bladder cancer.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2021)

Add to Collection

Article Biotechnology & Applied Microbiology

Identification of a Nine Immune-Related lncRNA Signature as a Novel Diagnostic Biomarker for Hepatocellular Carcinoma

Mengqin Yuan et al.

Summary: This study identified a nine-lncRNA signature with potential prognostic value for patients with HCC, which could be used as a new biomarker for the diagnosis and immunotherapy of HCC. The risk score based on the expression of these lncRNAs was associated with the prognosis of HCC patients, and immune-related mechanisms were found to be involved in the progression of HCC.

BIOMED RESEARCH INTERNATIONAL (2021)

Add to Collection

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Add to Collection

Article Biotechnology & Applied Microbiology

Identification and Construction of a Long Noncoding RNA Prognostic Risk Model for Stomach Adenocarcinoma Patients

Zhiqiang Zha et al.

Summary: In this study, a lncRNA-based prognostic risk model for STAD patients was constructed using TCGA data. Four differentially expressed lncRNAs were identified, and a prognostic model was established. GO and KEGG analysis confirmed the significance of the selected lncRNA in tumorigenesis.

DISEASE MARKERS (2021)

Add to Collection

Article Oncology

LINC00460/DHX9/IGF2BP2 complex promotes colorectal cancer proliferation and metastasis by mediating HMGA1 mRNA stability depending on m6A modification

Pingfu Hou et al.

Summary: The study found that LINC00460 is upregulated in CRC and high expression is associated with poor survival rates. LINC00460 interacts with IGF2BP2 and DHX9 to enhance the stability of HMGA1 mRNA through m6A modification, promoting cell proliferation, migration, and invasion in CRC.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

Add to Collection

Article Pharmacology & Pharmacy

Development and clinical validation of a novel 9-gene prognostic model based on multi-omics in pancreatic adenocarcinoma

Dafeng Xu et al.

Summary: This study integrated genomic mutated genes and prognosis-related genes to construct a predictive model with 9 characteristic genes, which could help identify samples at risk and demonstrated superior overall predictive performance in training and external validation cohorts.

PHARMACOLOGICAL RESEARCH (2021)

Add to Collection

Article Genetics & Heredity

Inflammation-Related Long Non-Coding RNA Signature Predicts the Prognosis of Gastric Carcinoma

ShuQiao Zhang et al.

Summary: A novel inflammation-related lncRNAs signature was developed to predict the prognosis of gastric carcinoma patients, showing a correlation between high-risk inflammation-related lncRNAs signature and poor prognosis. The utility of the inflammation-related lncRNAs signature in predicting gastric carcinoma prognosis was supported by an AUC of 0.788, with further immune and tumor-related pathway analysis revealing differences between low and high-risk groups.

FRONTIERS IN GENETICS (2021)

Add to Collection

Review Oncology

T-cell intrinsic Toll-like receptor signaling: implications for cancer immunotherapy and CAR T-cells

Yasmin Nouri et al.

Summary: TLRs expressed within T-cells serve as important costimulatory and regulatory molecules that enhance T-cell function and memory, while incorporating TLR signaling domains into CAR T-cells allows for the specific exploitation of T-cell intrinsic TLR function, presenting a new opportunity for cancer immunotherapies.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Add to Collection

Article Medicine, General & Internal

A Novel Autophagy-Related lncRNA Prognostic Signature Associated with Immune Microenvironment and Survival Outcomes of Gastric Cancer Patients

Di Chen et al.

Summary: This study identified a prognostic signature of 5 autophagy-related lncRNAs in gastric cancer, which serves as an independent prognostic indicator with higher prediction efficiency than other clinicopathological parameters. Patients with high-risk scores exhibited a stronger immunosuppressive microenvironment compared to low-risk patients. Enrichment analysis of co-expressed mRNAs indicated significant enrichment of autophagy-related signaling pathways. PCA and GSEA further revealed distinct autophagy and immune status between high-risk and low-risk groups.

INTERNATIONAL JOURNAL OF GENERAL MEDICINE (2021)

Add to Collection

Article Oncology

Applying immune-related lncRNA pairs to construct a prognostic signature and predict the immune landscape of stomach adenocarcinoma

Yujiao Wang et al.

Summary: In this study, an immune-related lncRNA pair signature consisting of 8 irlncRNA pairs was constructed for stomach adenocarcinoma (STAD) patients, showing strong prognostic predictive value through external validation. The risk score was identified as an independent prognostic factor, and significant differences in immune cell infiltration, response to drug treatments, and tumor mutation burden (TMB) were observed between patients with high and low risk scores.

EXPERT REVIEW OF ANTICANCER THERAPY (2021)

Add to Collection

Review Cell Biology

Toll-Like Receptor Signaling in the Establishment and Function of the Immune System

Jahnavi Aluri et al.

Summary: Toll-like receptors (TLRs) are important in the development of the immune system, aberrant TLR signaling is associated with hematopoietic and immune system dysfunction. Variants in TLR signaling-associated genes may affect infection susceptibilities and immune defects.

CELLS (2021)

Add to Collection

Article Oncology

Effects of Inflammation on the Immune Microenvironment in Gastric Cancer

Weidan Zhao et al.

Summary: By establishing the inflammatory response model score Riskscore, the study revealed the relationship between inflammation-related genes and immune gene expression in the development and progression of gastric cancer. The prognosis significantly differed between high- and low-risk groups, with the high-risk group showing lower survival rates and times. These findings contribute to improving prognosis prediction for gastric cancer and provide new insights for immunotherapy in gastric cancer patients.

FRONTIERS IN ONCOLOGY (2021)

Add to Collection

Review Oncology

RNA in cancer

Gregory J. Goodall et al.

Summary: Recent findings have shown that RNA processing is systematically altered in cancer, with mutations in RNA splicing factor genes and the shortening of 3' untranslated regions widely observed. Additionally, evidence suggests that other types of RNAs, including circular RNAs, can contribute to tumorigenesis.

NATURE REVIEWS CANCER (2021)

Add to Collection

Review Medicine, General & Internal

Prognostic significance of LINC00460 overexpression in solid tumours: a meta-analysis

Chen Dai et al.

POSTGRADUATE MEDICAL JOURNAL (2020)

Add to Collection

Article Medicine, Research & Experimental

Upregulation of lncRNA LINC00460 Facilitates GC Progression through Epigenetically Silencing CCNG2 by EZH2/LSD1 and Indicates Poor Outcomes

Jiebin Yang et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2020)

Add to Collection

Review Immunology

Relationships Between Immune Landscapes, Genetic Subtypes and Responses to Immunotherapy in Colorectal Cancer

Emilie Picard et al.

FRONTIERS IN IMMUNOLOGY (2020)

Add to Collection

Article Cell Biology

A novel lncRNA PLK4 up-regulated by talazoparib represses hepatocellular carcinoma progression by promoting YAP-mediated cell senescence

Yan Jia et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

Add to Collection

Review Biochemistry & Molecular Biology

Long non-coding RNAs towards precision medicine in gastric cancer: early diagnosis, treatment, and drug resistance

Li Yuan et al.

MOLECULAR CANCER (2020)

Add to Collection

Article Multidisciplinary Sciences

Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I

Keisuke Yamamoto et al.

NATURE (2020)

Add to Collection

Article Oncology

Gastric cancer risk-scoring system based on analysis of a competing endogenous RNA network

Min Liu et al.

TRANSLATIONAL CANCER RESEARCH (2020)

Add to Collection

Article Immunology

SnapShot: TP53 status and macrophages infiltration in TCGA-analyzed tumors

Amr Ahmed El-Arabey et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

Add to Collection

Article Cell Biology

Long non-coding RNA ADAMTS9-AS1 suppresses colorectal cancer by inhibiting the Wnt/β-catenin signalling pathway and is a potential diagnostic biomarker

Ning Li et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

Add to Collection

Article Medicine, General & Internal

Gastric cancer

Elizabeth C Smyth et al.

LANCET (2020)

Add to Collection

Article Cell Biology

LncRNA ADAMTS9-AS1, as prognostic marker, promotes cell proliferation and EMT in colorectal cancer

Wanjing Chen et al.

HUMAN CELL (2020)

Add to Collection

Article Oncology

A three-lncRNA signature of pretreatment biopsies predicts pathological response and outcome in esophageal squamous cell carcinoma with neoadjuvant chemoradiotherapy

Chaoqi Zhang et al.

CLINICAL AND TRANSLATIONAL MEDICINE (2020)

Add to Collection

Review Immunology

Tumor-Associated Macrophages in Tumor Immunity

Yueyun Pan et al.

FRONTIERS IN IMMUNOLOGY (2020)

Add to Collection

Review Cell Biology

On the evolution of cellular senescence

Axel Kowald et al.

AGING CELL (2020)

Add to Collection

Review Cell Biology

Cancer-associated fibroblasts in tumor microenvironment - Accomplices in tumor malignancy

Zehuan Liao et al.

CELLULAR IMMUNOLOGY (2019)

Add to Collection

Review Physiology

CELLULAR SENESCENCE: AGING, CANCER, AND INJURY

Arianna Calcinotto et al.

PHYSIOLOGICAL REVIEWS (2019)

Add to Collection

Article Multidisciplinary Sciences

The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype

Priya Hari et al.

SCIENCE ADVANCES (2019)

Add to Collection

Article Oncology

Combination of TMB and CNA Stratifies Prognostic and Predictive Responses to Immunotherapy Across Metastatic Cancer

Li Liu et al.

CLINICAL CANCER RESEARCH (2019)

Add to Collection

Article Oncology

LncRNA LINC00460 promotes EMT in head and neck squamous cell carcinoma by facilitating peroxiredoxin-1 into the nucleus

Yingying Jiang et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

Add to Collection

Article Cell Biology

Cellular senescence induced by S100A9 in mesenchymal stromal cells through NLRP3 inflammasome activation

Lei Shi et al.

AGING-US (2019)

Add to Collection

Article Medicine, Research & Experimental

LINC00460 promotes hepatocellular carcinoma development through sponging miR-485-5p to up-regulate PAK1

Janfei Tu et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Add to Collection

Review Biotechnology & Applied Microbiology

Immunotherapy for gastric cancer: dilemmas and prospect

Qingfang Zhao et al.

BRIEFINGS IN FUNCTIONAL GENOMICS (2019)

Add to Collection

Article Multidisciplinary Sciences

Senescence-associated reprogramming promotes cancer stemness

Maja Milanovic et al.

NATURE (2018)

Add to Collection

Article Cell Biology

Negative Regulation of Cytokine Signaling in Immunity

Akihiko Yoshimura et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response

Peng Jiang et al.

NATURE MEDICINE (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Maftools: efficient and comprehensive analysis of somatic variants in cancer

Anand Mayakonda et al.

GENOME RESEARCH (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Targeting LINC00673 expression triggers cellular senescence in lung cancer

Anna Roth et al.

RNA BIOLOGY (2018)

Add to Collection

Letter Medicine, General & Internal

Tumor Mutational Burden and Response Rate to PD-1 Inhibition

Mark Yarchoan et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Add to Collection

Review Cell Biology

Cellular senescence impact on immune cell fate and function

Rita Vicente et al.

AGING CELL (2016)

Add to Collection

Article Oncology

Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression

Tobias Eggert et al.

CANCER CELL (2016)

Add to Collection

Article Biochemistry & Molecular Biology

NF-κB-HOTAIR axis links DNA damage response, chemoresistance and cellular senescence in ovarian cancer

A. R. Ozes et al.

ONCOGENE (2016)

Add to Collection

Article Biochemistry & Molecular Biology

limma powers differential expression analyses for RNA-sequencing and microarray studies

Matthew E. Ritchie et al.

NUCLEIC ACIDS RESEARCH (2015)

Add to Collection

Review Immunology

Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity

Jason W. Griffith et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 32 (2014)

Add to Collection

Review Immunology

NOD1 and NOD2: Signaling, Host Defense, and Inflammatory Disease

Roberta Caruso et al.

IMMUNITY (2014)

Add to Collection

Article Biochemical Research Methods

GSVA: gene set variation analysis for microarray and RNA-Seq data

Sonja Haenzelmann et al.

BMC BIOINFORMATICS (2013)

Add to Collection

Article Oncology

p53-Mediated Senescence Impairs the Apoptotic Response to Chemotherapy and Clinical Outcome in Breast Cancer

James G. Jackson et al.

CANCER CELL (2012)

Add to Collection

Article Oncology

Tumor Stroma-Derived TGF-β Limits Myc-Driven Lymphomagenesis via Suv39h1-Dependent Senescence

Maurice Reimann et al.

CANCER CELL (2010)

Add to Collection

Article Biotechnology & Applied Microbiology

What is principal component analysis?

Markus Ringner

NATURE BIOTECHNOLOGY (2008)

Add to Collection

Article Biochemistry & Molecular Biology

Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence

Jean-Philippe Coppe et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Add to Collection

Article Multidisciplinary Sciences

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

A Subramanian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Add to Collection

Article Multidisciplinary Sciences

Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging

A Krtolica et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

Add to Collection

© Peeref 2019-2024. All rights reserved.