☆ 4.6 Article

EIF2S2 is a novel independent prognostic biomarker and correlated with immune infiltrates in hepatocellular carcinoma

FRONTIERS IN GENETICS (2022)

Related references

Note: Only part of the references are listed.

Review Oncology

Immunotherapies for hepatocellular carcinoma

Justin K. H. Liu et al.

Summary: Cases of hepatocellular carcinoma are rapidly rising, particularly in the Western world. Traditional treatment options are reserved for early stage patients, while recent scientific advances in cancer immunotherapy have brought new hope for advanced cases.

CANCER MEDICINE (2022)

Add to Collection

Article Medicine, General & Internal

Identification of PDCD1 and PDCD1LG2 as Prognostic Biomarkers and Associated with Immune Infiltration in Hepatocellular Carcinoma

Wang Li et al.

Summary: This study comprehensively investigated the prognostic significance of immune checkpoints in hepatocellular carcinoma (HCC) and their correlation with immune infiltration. The results indicated that PDCD1 and PDCD1LG2 are prognostic biomarkers in HCC and are related to immune infiltration.

INTERNATIONAL JOURNAL OF GENERAL MEDICINE (2022)

Add to Collection

Review Pharmacology & Pharmacy

Engineering interferons and interleukins for cancer immunotherapy

Patrick G. Holder et al.

Summary: Cytokines are potent immunoregulatory proteins that play important roles in cancer and have the potential for cancer immunotherapy. However, the use of cytokines as therapeutics has been limited by their complex biology and toxicities. Recent advances in immune checkpoint inhibitors and combination immunotherapies have reinvigorated interest in cytokines as therapeutics.

ADVANCED DRUG DELIVERY REVIEWS (2022)

Add to Collection

Article Medicine, Research & Experimental

Cancer cell's internal and external warriors: Autophagosomes and exosomes

V. A. Subramanian et al.

Summary: This article discusses the roles of autophagy and exosomes in the cancer cell's adaptation to the tumor microenvironment and how the two pathways are coordinately regulated to facilitate cancer cell survival.

LIFE SCIENCES (2022)

Add to Collection

Review Oncology

Addressing the worldwide hepatocellular carcinoma: epidemiology, prevention and management

Hrishikesh Samant et al.

Summary: Hepatocellular carcinoma (HCC) is the sixth most common cancer in the world with rising incidence. There has been substantial variation in prevalence of risk factors for HCC over the years, and early detection through surveillance is crucial for reducing mortality. Treatment options for HCC depend on the stage of the tumor and severity of underlying liver disease, with recent advances in therapy changing management for intermediate and advanced stages of HCC.

JOURNAL OF GASTROINTESTINAL ONCOLOGY (2021)

Add to Collection

Article Gastroenterology & Hepatology

Liver transarterial chemoembolization and sunitinib for unresectable hepatocellular carcinoma: Results of the PRODIGE 16 study

Anthony Turpin et al.

Summary: The study showed that TACE combined with sunitinib in patients with HCC who are not suitable for surgical resection was feasible and had good efficacy, with acceptable safety outcomes.

CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY (2021)

Add to Collection

Review Immunology

Immunobiology and immunotherapy of HCC: spotlight on innate and innate-like immune cells

Benjamin Ruf et al.

Summary: Immune-based therapies, particularly immune checkpoint inhibitors, have shown significant improvements in the treatment of hepatocellular carcinoma (HCC), but durable responses are limited to a subset of patients. Understanding the immunologic mechanisms shaping the unique tumor microenvironment of liver cancer is crucial for developing effective therapeutic strategies. Current research focuses on targeting immune cells within the liver to enhance the therapeutic potential of immunotherapeutic agents.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

Add to Collection

Review Immunology

The interactions between major immune effector cells and Hepatocellular Carcinoma: A systematic review

Markus Bo Schoenberg et al.

Summary: This review summarizes the interactions between major immune effector cells and HCC cells to provide new insights for HCC immunotherapy. The studies indicate that CD8(+) T lymphocytes and NK cells can inhibit HCC cells, but HCC cells can also lead to dysfunction of these effector cells through various mechanisms. Innovative approaches like organoids and direct contact cell co-culture are suggested for investigating the interactions and developing novel immunotherapy strategies.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

Add to Collection

Article Medicine, General & Internal

Development and validation of a robust immune-related risk signature for hepatocellular carcinoma

Zaoqu Liu et al.

Summary: This study developed a robust immune-related risk signature for hepatocellular carcinoma (HCC) based on immune-related genes, utilizing data from TCGA and ICGC databases. A predictive nomogram was built to reliably predict overall survival in HCC patients. The abnormal expression of immune-related risk genes was found to be correlated with HCC development, and the signature enriched an intensive immune phenotype.

MEDICINE (2021)

Add to Collection

Review Gastroenterology & Hepatology

Locoregional therapies in the era of molecular and immune treatments for hepatocellular carcinoma

Josep M. Llovet et al.

Summary: Locoregional therapies, including local ablation and transarterial chemoembolization, play a crucial role in the management of hepatocellular carcinoma. Recent studies have shown potential benefits of combining these local therapies with systemic treatments, such as molecular therapies, to enhance therapeutic effects.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2021)

Add to Collection

Review Immunology

Strategies to Improve the Antitumor Effect of Immunotherapy for Hepatocellular Carcinoma

Rui Xing et al.

Summary: Hepatocellular carcinoma (HCC) is a deadly malignancy diagnosed late with limited treatment options and poor prognosis. Combination therapies involving multiple ICIs, antiangiogenic drugs, and locoregional treatments have become a new strategy for HCC treatment, aiming to improve efficacy through synergistic effects.

FRONTIERS IN IMMUNOLOGY (2021)

Add to Collection

Article Multidisciplinary Sciences

Geriatric nutritional risk index predicts prognosis in hepatocellular carcinoma after hepatectomy: a propensity score matching analysis

Hiroki Kanno et al.

Summary: The study found that the geriatric nutritional risk index (GNRI) can be used to predict long-term outcomes in hepatocellular carcinoma after hepatectomy, with high GNRI associated with better recurrence-free survival and overall survival.

SCIENTIFIC REPORTS (2021)

Add to Collection

Review Gastroenterology & Hepatology

Epidemiology of non-alcoholic fatty liver disease and hepatocellular carcinoma

Zobair M. Younossi et al.

Summary: The prevalence of hepatocellular carcinoma (HCC) is rising globally, especially in patients with non-alcoholic fatty liver disease (NAFLD) due to obesity and type 2 diabetes epidemics. Lack of awareness about NAFLD-related HCC results in late diagnosis and low survival rates.

JHEP REPORTS (2021)

Add to Collection

Article Oncology

Identification of Potential Biomarkers From Hepatocellular Carcinoma With MT1 Deletion

Ruohao Zhang et al.

Summary: This study demonstrated that MT1-deletion can act as an independent prognostic factor in HCC. By analyzing the CNV data of 79 Guangxi HCC patients, it was found that the expression of four MT1s were down-regulated in HCC. The hub genes identified, such as TTK, BUB1, NR1I2, CYP8B1, were associated with the prognosis of HCC with MT1-deletion.

PATHOLOGY & ONCOLOGY RESEARCH (2021)

Add to Collection

Review Gastroenterology & Hepatology

Epidemiology and surveillance for hepatocellular carcinoma: New trends

Amit G. Singal et al.

JOURNAL OF HEPATOLOGY (2020)

Add to Collection

Article Biotechnology & Applied Microbiology

RBP EIF2S2 Promotes Tumorigenesis and Progression by Regulating MYC-Mediated Inhibition via FHIT-Related Enhancers

Jiwei Zhang et al.

MOLECULAR THERAPY (2020)

Add to Collection

Article Biochemistry & Molecular Biology

TIMER2.0 for analysis of tumor-infiltrating immune cells

Taiwen Li et al.

NUCLEIC ACIDS RESEARCH (2020)

Add to Collection

Review Medicine, General & Internal

Autophagy in Human Diseases

Noboru Mizushima et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Add to Collection

Review Oncology

LAG-3: from molecular functions to clinical applications

Takumi Maruhashi et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

Add to Collection

Article Oncology

Prognostic implications of alcohol dehydrogenases in hepatocellular carcinoma

Xiangye Liu et al.

BMC CANCER (2020)

Add to Collection

Article Oncology

Synergizing sunitinib and radiofrequency ablation to treat hepatocellular cancer by triggering the antitumor immune response

Xiaoqiang Qi et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

Add to Collection

Article Gastroenterology & Hepatology

Integrating the Epigenome to Identify Drivers of Hepatocellular Carcinoma

Ryan A. Hlady et al.

HEPATOLOGY (2019)

Add to Collection

Review Gastroenterology & Hepatology

Biomarkers: What Role Do They Play (If Any) for Diagnosis, Prognosis and Tumor Response Prediction for Hepatocellular Carcinoma?

James J. Harding et al.

DIGESTIVE DISEASES AND SCIENCES (2019)

Add to Collection

Review Gastroenterology & Hepatology

Hepatocellular carcinoma in the setting of alcohol-related liver disease

Nathalie Ganne-Carrie et al.

JOURNAL OF HEPATOLOGY (2019)

Add to Collection

Review Medicine, General & Internal

Hepatocellular Carcinoma

Augusto Villanueva

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Add to Collection

Review Gastroenterology & Hepatology

Hepatocellular carcinoma: Mechanisms of progression and immunotherapy

Yu Jiang et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2019)

Add to Collection

Article Gastroenterology & Hepatology

Epidemiology and Management of Hepatocellular Carcinoma

Laura Kulik et al.

GASTROENTEROLOGY (2019)

Add to Collection

Article Medicine, General & Internal

MiR-506 Promotes Natural Killer Cell Cytotoxicity against Human Hepatocellular Carcinoma Cells by Targeting STAT3

Zhixiong Su et al.

YONSEI MEDICAL JOURNAL (2019)

Add to Collection

Article Oncology

The PI3K/Akt/GSK-3β/ROS/eIF2B pathway promotes breast cancer growth and metastasis via suppression of NK cell cytotoxicity and tumor cell susceptibility

Fengjiao Jin et al.

CANCER BIOLOGY & MEDICINE (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Chitosan-coated doxorubicin nano-particles drug delivery system inhibits cell growth of liver cancer via p53/PRC1 pathway

Bai-liang Ye et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Add to Collection

Article Oncology

eIF2β, a subunit of translation-initiation factor EIF2, is a potential therapeutic target for non-small cell lung cancer

Ichidai Tanaka et al.

CANCER SCIENCE (2018)

Add to Collection

Review Immunology

PD-1/PD-L1 in disease

Nyanbol Kuol et al.

IMMUNOTHERAPY (2018)

Add to Collection

Review Immunology

The immunology of hepatocellular carcinoma

Marc Ringelhan et al.

NATURE IMMUNOLOGY (2018)

Add to Collection

Article Multidisciplinary Sciences

Deviations of the immune cell landscape between healthy liver and hepatocellular carcinoma

Nataliya Rohr-Udilova et al.

SCIENTIFIC REPORTS (2018)

Add to Collection

Review Medicine, General & Internal

Prognostic value of tumor-infiltrating lymphocytes in hepatocellular carcinoma A meta-analysis

Wei Ding et al.

MEDICINE (2018)

Add to Collection

Review Oncology

Immunotherapy of Hepatocellular Carcinoma: Facts and Hopes

Mercedes Inarrairaegui et al.

CLINICAL CANCER RESEARCH (2018)

Add to Collection

Review Oncology

Sunitinib in kidney cancer: 10 years of experience and development

Elise Nassif et al.

EXPERT REVIEW OF ANTICANCER THERAPY (2017)

Add to Collection

Review Oncology

Immune cells in liver regeneration

Na Li et al.

ONCOTARGET (2017)

Add to Collection

Review Immunology

Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation

Ana C. Anderson et al.

IMMUNITY (2016)

Add to Collection

Article Multidisciplinary Sciences

Crystal structure of eukaryotic translation initiation factor 2B

Kazuhiro Kashiwagi et al.

NATURE (2016)

Add to Collection

Article Oncology

BTLA identifies dysfunctional PD-1-expressing CD4(+) T cells in human hepatocellular carcinoma

Qiyi Zhao et al.

ONCOIMMUNOLOGY (2016)

Add to Collection

Article Oncology

High CHMP4B expression is associated with accelerated cell proliferation and resistance to doxorubicin in hepatocellular carcinoma

Baoying Hu et al.

TUMOR BIOLOGY (2015)

Add to Collection

Article Multidisciplinary Sciences

pRRophetic: An R Package for Prediction of Clinical Chemotherapeutic Response from Tumor Gene Expression Levels

Paul Geeleher et al.

PLOS ONE (2014)

Add to Collection

Article Biochemistry & Molecular Biology

hABCF3, a TPD52L2 interacting partner, enhances the proliferation of human liver cancer cell lines in vitro

Juan Zhou et al.

MOLECULAR BIOLOGY REPORTS (2013)

Add to Collection

Review Cell Biology

Innate Immune Cells in Liver Inflammation

Evaggelia Liaskou et al.

MEDIATORS OF INFLAMMATION (2012)

Add to Collection

Article Biotechnology & Applied Microbiology

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

Guangchuang Yu et al.

OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY (2012)

Add to Collection

Article Biochemical Research Methods

pROC: an open-source package for R and S plus to analyze and compare ROC curves

Xavier Robin et al.

BMC BIOINFORMATICS (2011)

Add to Collection

Article Oncology

Phase I clinical trial of hepatic arterial infusion of paclitaxel in patients with advanced cancer and dominant liver involvement

Apostolia M. Tsimberidou et al.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2011)

Add to Collection

Article Biochemistry & Molecular Biology

Deletion of eIF2beta suppresses testicular cancer incidence and causes recessive lethality in agouti-yellow mice

Jason D. Heaney et al.

HUMAN MOLECULAR GENETICS (2009)

Add to Collection

Review Immunology

Plasticity of CD4+ T Cell Lineage Differentiation

Liang Zhou et al.

IMMUNITY (2009)

Add to Collection

Review Multidisciplinary Sciences

Cancer-related inflammation

Alberto Mantovani et al.

NATURE (2008)

Add to Collection

Article Biochemical Research Methods

Proteome analysis of apoptosis signaling by S-trityl-L-cysteine, a potent reversible inhibitor of human mitotic kinesin Eg5

Frank Kozielski et al.

PROTEOMICS (2008)

Add to Collection

Article Oncology

Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment

Anuradha Budhu et al.

CANCER CELL (2006)

Add to Collection

© Peeref 2019-2024. All rights reserved.