Journal
FRONTIERS IN GENETICS
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fgene.2022.984273
Keywords
anoikis; model; bioinformatics; prognosis; HNSCC
Categories
Funding
- Southwestern Medical University
- [2020XSJG-C01-21]
Ask authors/readers for more resources
This study constructed a prognostic model for HNSCC using anoikis-related genes (ANRGs) and found differential immune status and drug sensitivity between high-risk and low-risk groups. In addition, through DCA analysis, the researchers demonstrated the potential clinical benefit of the model in the clinical practice.
Background: Head and neck squamous cell carcinoma (HNSCC) is a highly aggressive disease with a poor prognosis for advanced tumors. Anoikis play a key role in cancer metastasis, facilitating the detachment and survival of cancer cells from the primary tumor site. However, few studies have focused on the role of anoikis in HNSC, especially on the prognosis. Methods: Anoikis-related genes (ANRGs) integrated from Genecards and Harmonizome portals were used to identify HNSCC subtypes and to construct a prognostic model for HNSCC patients. Also, we explored the immune microenvironment and enrichment pathways between different subtypes. Finally, we provide clinical experts with a novel nomogram based on ANRGs, with DCA curves indicating the potential clinical benefit of the model for clinical strategies. Results: We identified 69 survival-related HNSCC anoikis-related DEGs, from which 7 genes were selected to construct prognostic models. The prognostic risk score was identified as an independent prognostic factor. Functional analysis showed that these high and low risk groups had different immune status and drug sensitivity. Next risk scores were combined with HNSCC clinicopathological features together to construct a nomogram, and DCA analysis showed that the model could benefit patients from clinical treatment strategies. Conclusion: The predictive seven-gene signature and nomogram established in this study can assist clinicians in selecting personalized treatment for patients with HNSCC.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available