☆ 4.6 Article

Identification of functional TF-miRNA-hub gene regulatory network associated with ovarian endometriosis

FRONTIERS IN GENETICS (2022)

Related references

Note: Only part of the references are listed.

Review Biology

Promising therapeutic targets of endometriosis obtained from microRNA studies

Kaei Nasu et al.

Summary: Endometriosis, affecting 6-10% of women of reproductive age, involves aberrant microRNA (miRNA) expressions in its pathogenesis, regulating specific characteristics in endometriotic cells and targeting downstream molecules. Imbalance between tumorigenic and tumoristatic miRNAs may determine the progression of the disease and the response to treatment. Further exploration of endometriosis-associated miRNAs could provide insights into the pathogenesis and novel therapeutic development.

MEDICAL MOLECULAR MORPHOLOGY (2022)

Add to Collection

Article Biochemistry & Molecular Biology

miRTarBase update 2022: an informative resource for experimentally validated miRNA-target interactions

Hsi-Yuan Huang et al.

Summary: miRTarBase is a large biological database that provides experimentally verified miRNA-target interactions, making it one of the most research-friendly MTI databases with comprehensive and experimentally verified annotations.

NUCLEIC ACIDS RESEARCH (2022)

Add to Collection

Article Cell Biology

Endometrial stromal cell ferroptosis promotes angiogenesis in endometriosis

Guojing Li et al.

Summary: Endometriosis, a chronic disorder characterized by abnormal distribution of tissue, can cause iron overload and oxidative stress. The study found that ferroptosis of endometrial stromal cells can trigger the secretion of cytokines, promoting angiogenesis in adjacent lesions. VEGFA and IL8, important angiogenic factors, are upregulated in ectopic lesions. These findings provide a rationale for clinical practice and drug development for endometriosis.

CELL DEATH DISCOVERY (2022)

Add to Collection

Article Medicine, General & Internal

Differential Expression of Tissular miRNA-155 in Pediatric Gastritis

Sasaran Maria Oana et al.

Summary: This study aimed to assess the differential expression of miR-155 in relation to pediatric gastritis. The results showed that miR-155 expression was increased in patients with gastritis but did not significantly differ from controls. The authors concluded that pediatric gastritis increases miR-155 expression, but this does not greatly impact its prognostic role.

JOURNAL OF CLINICAL MEDICINE (2022)

Add to Collection

Review Biochemistry & Molecular Biology

Ferroptosis as a novel form of regulated cell death: Implications in the pathogenesis, oncometabolism and treatment of human cancer

Feifei Pu et al.

Summary: The treatment of cancer involves surgical excision, radiotherapy, and chemotherapy. Chemotherapy drugs interfere with tumor growth and induce cancer cell death. Ferroptosis, a newly discovered iron-dependent type of cell death, is negatively correlated with cancer development and primarily caused by an abnormal increase in iron-dependent reactive oxygen species and the imbalance of redox homeostasis.

GENES & DISEASES (2022)

Add to Collection

Review Obstetrics & Gynecology

Postoperative hormonal treatment for prevention of endometrioma recurrence after ovarian cystectomy: a systematic review and network meta-analysis

R. Wattanayingcharoenchai et al.

Summary: This study compared and ranked the efficacy of different hormonal regimens in preventing endometrioma recurrence after conservative surgery. The results indicated that long-term hormonal treatment, such as LNG-IUS, was more effective in reducing the risk of recurrence compared to expectant management.

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY (2021)

Add to Collection

Review Developmental Biology

The role of hypoxia in the development and progression of endometriosis

Wan-Ning Li et al.

Summary: Endometriosis is a benign gynecological disease affecting approximately 10% of women of reproductive age, leading to symptoms such as dysmenorrhea, dyspareunia, and infertility. Hypoxia plays a critical role in the disease phenotypes of endometriosis, influencing factors such as adhesion ability, estrogen biosynthesis, proinflammatory cytokines, angiogenic ability, and immune functions. Targeting HIF and downstream effectors may offer potential therapeutic options for endometriosis treatment.

REPRODUCTION (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Targeting Hypoxia-Inducible Factor-1-Mediated Metastasis for Cancer Therapy

Zhaowu Ma et al.

Summary: Hypoxia plays a crucial role in the tumor microenvironment, correlating with tumor metastasis and prognosis. HIF-1α, a key molecule, is involved in multiple crucial steps in the metastatic cascade. Currently, researchers are focusing on potential pharmacological interventions and developing HIF-1 inhibitors to block tumor metastasis.

ANTIOXIDANTS & REDOX SIGNALING (2021)

Add to Collection

Article Obstetrics & Gynecology

Erastin induces ferroptosis via ferroportin-mediated iron accumulation in endometriosis

Yajie Li et al.

Summary: Summary: Erastin can induce ferroptosis to regress endometriotic lesions. EESCs are more susceptible to erastin treatment compared to NESCs.

HUMAN REPRODUCTION (2021)

Add to Collection

Article Obstetrics & Gynecology

Risk of cardiovascular outcomes among women with endometriosis in the United Kingdom: a retrospective matched cohort study

K. Okoth et al.

Summary: The study shows that women with endometriosis have a higher risk of cardiovascular outcomes compared to those without the condition, particularly in terms of ischemic heart disease, cerebrovascular disease, and heart failure. Although the incidence of endometriosis has decreased over the years, the prevalence of the condition has been on the rise.

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY (2021)

Add to Collection

Review Medicine, Research & Experimental

CD9, a tetraspanin target for cancer therapy?

Aurelio Lorico et al.

Summary: In this review, the history of CD9 involvement in oncogenesis and cancer metastasis is briefly discussed, highlighting its potential value as a tumor-associated antigenic target. CD9 has been identified as a favorable prognostic marker or predictor of metastatic potential depending on the cancer type. Besides its use as an antigenic biomarker, CD9 plays a role in intercellular communication under physiological and pathological conditions, notably in the establishment of cancer metastases.

EXPERIMENTAL BIOLOGY AND MEDICINE (2021)

Add to Collection

Article Medicine, General & Internal

Endometriosis is a chronic systemic disease: clinical challenges and novel innovations

Hugh S Taylor et al.

LANCET (2021)

Add to Collection

Article Multidisciplinary Sciences

Construction of a TF-miRNA-gene feed-forward loop network predicts biomarkers and potential drugs for myasthenia gravis

Chunrui Bo et al.

Summary: The study constructed a TF-miRNA-gene network and identified potential drugs for myasthenia gravis by analyzing regulatory motifs, pathways, and GO enrichment. The CFMSN revealed key transcription factors and miRNAs related to MG, highlighting the potential for novel treatments.

SCIENTIFIC REPORTS (2021)

Add to Collection

Article Multidisciplinary Sciences

Identification of hub genes and transcription factor-miRNA-mRNA pathways in mice and human renal ischemia-reperfusion injury

Peng Ke et al.

Summary: In this study, 15 hub genes and multiple TF-miRNA-mRNA pathways were identified in renal IRI, aiding in the understanding of molecular and regulatory mechanisms. Junb-miR-223-Ranbp3l, Cebpb-miR-223-Ranbp3l, Cebpb-miR-21Ranbp3l, and Cebpb-miR-181b-Bsnd were highlighted as the most important pathways, with Spp1, Fos, Timp1, Tnc, Fosl2, and Junb as key hub genes. Potential negative feedback loops in renal IRI were identified, including Fosl2-miR-155, Fosl2-miR-146a, Cebpb-miR-155, and Mafk-miR-25.

PEERJ (2021)

Add to Collection

Article Biochemistry & Molecular Biology

miRNAs and lncRNAs: Potential Non-Invasive Biomarkers for Endometriosis

Ioana Maria Maier et al.

Summary: Numerous studies have explored the mechanism and manifestation of endometriosis, highlighting the need for non-invasive diagnostic methods like miRNAs and lncRNAs to diagnose the condition early and alleviate patient suffering. Multiple clinical trials suggest that miRNA can serve as a non-invasive diagnostic tool for differentiating endometriosis stages.

BIOMEDICINES (2021)

Add to Collection

Article Cell Biology

Iron overload in endometriosis peritoneal fluid induces early embryo ferroptosis mediated by HMOX1

Shishi Li et al.

Summary: The study found that iron overload in the peritoneal fluid of endometriosis patients can lead to abnormalities in mouse embryo development, mainly through disrupting blastocyst formation, inducing lipid peroxidation, and causing mitochondrial damage to induce embryonic ferroptosis. Furthermore, the ferroptosis inhibitor Fer-1 can alleviate the cytotoxicity caused by iron overload.

CELL DEATH DISCOVERY (2021)

Add to Collection

Article Oncology

Hypoxia-induced lactate dehydrogenase A protects cells from apoptosis in endometriosis

Jinyan Zheng et al.

Summary: High expression of LDHA was found in endometriotic tissues, indicating a significant role in the pathogenesis of endometriosis. Hypoxia treatment induced LDHA expression, and silencing of LDHA promoted impaired mitochondrial function and apoptosis while inhibiting migration and glycolysis.

MOLECULAR MEDICINE REPORTS (2021)

Add to Collection

Article Medicine, General & Internal

Screening differentially expressed genes between endometriosis and ovarian cancer to find new biomarkers for endometriosis

Zhenzhen Lu et al.

Summary: This study identified potential therapeutic biomarkers for endometriosis by analyzing endometriosis and ovarian cancer datasets, validated key genes associated with recurrence and survival, and screened relevant therapeutic agents and potential therapeutic targets.

ANNALS OF MEDICINE (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Endometriosis: Etiology, pathobiology, and therapeutic prospects

Philippa T. K. Saunders et al.

Summary: Endometriosis is a common condition associated with infertility that causes chronic pain in women. The exact cause and natural history are still uncertain, but hormonal, neurological, and immunological factors are believed to play a role in the development of symptoms. Current interventions have limited efficacy with high rates of symptom recurrence.

CELL (2021)

Add to Collection

Article Biochemistry & Molecular Biology

MiRNA 34-a regulate SIRT-1 and Foxo-1 expression in endometriosis

Noha A. Rezk et al.

Summary: The study revealed that SIRT-1 and Bcl-xL genes were significantly up-regulated in endometrial tissue of endometriotic patients, while miRNA34-a, p53, Bax, Bcl-2, and FoxO-1 were down-regulated. There was an inverse relationship between the expressions of SIRT-1, Bcl-xL genes and miR-34a, p53, Bax, Bcl-2, and FoxO-1.

NON-CODING RNA RESEARCH (2021)

Add to Collection

Article Medicine, Research & Experimental

The miR-25-3p/Sp1 pathway is dysregulated in ovarian endometriosis

Licong Shen et al.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH (2020)

Add to Collection

Article Medicine, Research & Experimental

Overexpressed circ-RPL15 predicts poor survival and promotes the progression of gastric cancer via regulating miR-502-3p/OLFM4/STAT3 pathway

Yutao Li et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

Add to Collection

Article Medicine, General & Internal

MiR-155 and MiR-665 role as potential non-invasive biomarkers for hepatocellular carcinoma in Egyptian patients with chronic hepatitis C virus infection

Amal Ahmed Mohamed et al.

JOURNAL OF TRANSLATIONAL INTERNAL MEDICINE (2020)

Add to Collection

Article Oncology

miR-93-5p enhances migration and invasion by targeting RGMB in squamous cell carcinoma of the head and neck

Shuiting Zhang et al.

JOURNAL OF CANCER (2020)

Add to Collection

Review Reproductive Biology

MicroRNAs in endometriosis: biological function and emerging biomarker candidates

Sarah Bjorkman et al.

BIOLOGY OF REPRODUCTION (2019)

Add to Collection

Article Biochemistry & Molecular Biology

c-Myc, RMRP, and miR-34a-5p form a positive-feedback loop to regulate cell proliferation and apoptosis in multiple myeloma

Xichun Xiao et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

Add to Collection

Article Obstetrics & Gynecology

Plasma miRNAs as biomarkers for endometriosis

A. Vanhie et al.

HUMAN REPRODUCTION (2019)

Add to Collection

Review Endocrinology & Metabolism

Rethinking mechanisms, diagnosis and management of endometriosis

Charles Chapron et al.

NATURE REVIEWS ENDOCRINOLOGY (2019)

Add to Collection

Review Biochemistry & Molecular Biology

Endometriosis and cancer

Hiroaki Kajiyama et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

Add to Collection

Review Cell Biology

An overview of microRNAs: Biology, functions, therapeutics, and analysis methods

Kioomars Saliminejad et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

Add to Collection

Article Allergy

MicroRNA

Thomas X. Lu et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)

Add to Collection

Article Endocrinology & Metabolism

Integration analysis of microRNA and mRNA paired expression profiling identifies deregulated microRNA-transcription factor-gene regulatory networks in ovarian endometriosis

Luyang Zhao et al.

REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY (2018)

Add to Collection

Review Biochemistry & Molecular Biology

Emerging Principles of Gene Expression Programs and Their Regulation

Scott D. Pope et al.

MOLECULAR CELL (2018)

Add to Collection

Article Integrative & Complementary Medicine

Understanding the Role of Gui-Zhi-Fu-Ling-Capsules (Chinese Medicine) for Treatment of Endometriosis in the Rat Model: Using NMR Based Metabolomics

Jue Zhou et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2018)

Add to Collection

Review Oncology

Lactate dehydrogenase A: A key player in carcinogenesis and potential target in cancer therapy

Yangbo Feng et al.

CANCER MEDICINE (2018)

Add to Collection

Review Immunology

CD9 Tetraspanin: A New Pathway for the Regulation of Inflammation?

Carole Brosseau et al.

FRONTIERS IN IMMUNOLOGY (2018)

Add to Collection

Article Obstetrics & Gynecology

Ovarian cyst removal influences ovarian reserve dependent on histology, size and type of operation

Melanie Henes et al.

WOMENS HEALTH (2018)

Add to Collection

Article Engineering, Mechanical

Complex mechanics of the heterogeneous extracellular matrix in cancer

Andrea Malandrino et al.

EXTREME MECHANICS LETTERS (2018)

Add to Collection

Review Reproductive Biology

Is the oocyte quality affected by endometriosis? A review of the literature

Ana Maria Sanchez et al.

JOURNAL OF OVARIAN RESEARCH (2017)

Add to Collection

Review Biochemistry & Molecular Biology

Reprogramming of central carbon metabolism in cancer stem cells

Tin Lok Wong et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2017)

Add to Collection

Article Cell Biology

MiR-485-3p and miR-485-5p suppress breast cancer cell metastasis by inhibiting PGC-1α expression

C. Lou et al.

CELL DEATH & DISEASE (2016)

Add to Collection

Review Medicine, General & Internal

Blood biomarkers for the non-invasive diagnosis of endometriosis

Vicki Nisenblat et al.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2016)

Add to Collection

Letter Biochemical Research Methods

miRWalk2.0: a comprehensive atlas of microRNA-target interactions

Harsh Dweep et al.

NATURE METHODS (2015)

Add to Collection

Article Endocrinology & Metabolism

Enhanced epithelial to mesenchymal transition (EMT) and upregulated MYC in ectopic lesions contribute independently to endometriosis

Katharina Proestling et al.

REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY (2015)

Add to Collection

Article Biochemical Research Methods

Transcription factor and microRNA co-regulatory loops: important regulatory motifs in biological processes and diseases

Hong-Mei Zhang et al.

BRIEFINGS IN BIOINFORMATICS (2015)

Add to Collection

Article Mathematical & Computational Biology

cytoHubba: identifying hub objects and sub-networks from complex interactome

Chia-Hao Chin et al.

BMC SYSTEMS BIOLOGY (2014)

Add to Collection

Article Cardiac & Cardiovascular Systems

Elevated microRNA-155 promotes foam cell formation by targeting HBP1 in atherogenesis

Fu-Ju Tian et al.

CARDIOVASCULAR RESEARCH (2014)

Add to Collection

Article Developmental Biology

Menstrual blood-derived stromal stem cells from women with and without endometriosis reveal different phenotypic and functional characteristics

Shohreh Nikoo et al.

MOLECULAR HUMAN REPRODUCTION (2014)

Add to Collection

Review Endocrinology & Metabolism

Endometriosis: pathogenesis and treatment

Paolo Vercellini et al.

NATURE REVIEWS ENDOCRINOLOGY (2014)

Add to Collection

Review Endocrinology & Metabolism

Molecular aspects of development and regulation of endometriosis

Yana B. Aznaurova et al.

REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY (2014)

Add to Collection

Article Obstetrics & Gynecology

The effect of endometriosis on in vitro fertilisation outcome: a systematic review and meta-analysis

H. M. Harb et al.

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY (2013)

Add to Collection

Article Obstetrics & Gynecology

Pathogenesis and pathophysiology of endometriosis

Richard O. Burney et al.

FERTILITY AND STERILITY (2012)

Add to Collection

Article Biotechnology & Applied Microbiology

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

Guangchuang Yu et al.

OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY (2012)

Add to Collection

Article Food Science & Technology

Decreased expression of aromatase in the Ishikawa and RL95-2 cells by the isoflavone, puerarin, is associated with inhibition of c-jun expression and AP-1 activity

Yanwei Li et al.

FOOD AND CHEMICAL TOXICOLOGY (2008)

Add to Collection

Article Endocrinology & Metabolism

Upstream stimulatory factor-2 regulates steroidogenic factor-1 expression in endometriosis

Hiroki Utsunomiya et al.

MOLECULAR ENDOCRINOLOGY (2008)

Add to Collection

Article Biochemistry & Molecular Biology

Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1α and HIF-2α expression in lung epithelial cells -: Implication of natural antisense HIF-1α

T Uchida et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Add to Collection

Article Obstetrics & Gynecology

Diagnostic delay in women with pain and endometriosis

GK Husby et al.

ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA (2003)

Add to Collection

Review Biochemistry & Molecular Biology

Regulation of angiogenesis by hypoxia: role of the HIF system

CW Pugh et al.

NATURE MEDICINE (2003)

Add to Collection

© Peeref 2019-2024. All rights reserved.