Design principles of bioinspired interfaces for biomedical applications in therapeutics and imaging

In the past two decades, we have witnessed rapid developments in nanotechnology, especially in biomedical applications such as drug delivery, biosensing, and bioimaging. The most commonly used nanomaterials in biomedical applications are nanoparticles, which serve as carriers for various therapeutic and contrast reagents. Since nanomaterials are in direct contact with biological samples, biocompatibility is one of the most important issues for the fabrication and synthesis of nanomaterials for biomedical applications. To achieve specific recognition of biomolecules for targeted delivery and biomolecular sensing, it is common practice to engineer the surfaces of nanomaterials with recognition moieties. This mini-review summarizes different approaches for engineering the interfaces of nanomaterials to improve their biocompatibility and specific recognition properties. We also focus on design strategies that mimic biological systems such as cell membranes of red blood cells, leukocytes, platelets, cancer cells, and bacteria.

Automated summary

In the past two decades, there have been significant advancements in nanotechnology, specifically in biomedical applications. Biocompatibility is a critical factor in the fabrication and synthesis of nanomaterials for biomedical use, and surface engineering is commonly used to improve their specific recognition properties. This mini-review provides an overview of different approaches and design strategies for enhancing the interfaces of nanomaterials.