Journal
ONCOIMMUNOLOGY
Volume 11, Issue 1, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/2162402X.2022.2127507
Keywords
Small extracellular vesicles; exosomes; CLL; tumor microenvironment; tumor immune escape; sEV-based biomarkers
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Funding
- Luxembourg National Research Fund (FNR)
- Fondation Cancer, Luxembourg [PRIDE15/10675146/CANBIO, INTER/DFG/16/11509946, C20/BM/14582635, C20/BM/14592342]
- Fonds National de la Recherche Scientifique (FNRS)-Televie [7.4509.20]
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Recently, small extracellular vesicles (sEVs) secreted from chronic lymphocytic leukemia (CLL) preclinical murine models were studied and found to selectively target CD8(+) T-cells, inducing cell exhaustion and inhibiting anti-tumor immune response. Furthermore, the gene expression of sEVs was correlated with patient treatment-free survival, overall survival, and clinical parameters.
Recently, small extracellular vesicles (sEVs) secreted in vivo from chronic lymphocytic leukemia (CLL) preclinical murine models were characterized. Leukemia microenvironment sEV (LME-sEVs) selectively target CD8(+) T-cells, inducing exhaustion and hampering anti-tumor immune response. Additionally, a sEV-related gene expression correlated with patient treatment-free survival, overall survival and clinical parameters.
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