Journal
CARCINOGENESIS
Volume 36, Issue 10, Pages 1085-1093Publisher
OXFORD UNIV PRESS
DOI: 10.1093/carcin/bgv123
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Funding
- NIH [R01 DK47297]
- NCI [R01 CA184820, P01 CA77839]
- National Colorectal Cancer Research Alliance (NCCRA)
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Chronic inflammation contributes to cancer development via multiple mechanisms. One potential mechanism is that chronic inflammation can generate an immunosuppressive microenvironment that allows advantages for tumor formation and progression. The immunosuppressive environment in certain chronic inflammatory diseases and solid cancers is characterized by accumulation of proinflammatory mediators, infiltration of immune suppressor cells and activation of immune checkpoint pathways in effector T cells. In this review, we highlight recent advances in our understanding of how immunosuppression contributes to cancer and how proinflammatory mediators induce the immunosuppressive microenvironment via induction of immunosuppressive cells and activation of immune checkpoint pathways.
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