4.2 Article

Endovascular therapy in acute anterior circulation large vessel occlusive patients with a large infarct core (ANGEL-ASPECT): protocol of a multicentre randomised trial

Related references

Note: Only part of the references are listed.
Article Neuroimaging

Endovascular reperfusion outcomes in patients with a stroke and low ASPECTS is highly dependent on baseline infarct volumes

Mehdi Bouslama et al.

Summary: This study aimed to compare the outcomes of patients undergoing ET based on baseline infarct volumes in low and high ASPECTS categories. The results showed that outcomes may vary significantly within the same ASPECTS category depending on infarct volume, and patients with ASPECTS <= 5 but baseline infarct volumes <= 70 cc may achieve independence in nearly 40% of cases.

JOURNAL OF NEUROINTERVENTIONAL SURGERY (2022)

Article Clinical Neurology

A randomized controlled trial to optimize patient's selection for endovascular treatment in acute ischemic stroke (SELECT2): Study protocol

Amrou Sarraj et al.

Summary: This study aims to demonstrate the efficacy and safety of endovascular thrombectomy in patients with large core strokes and to determine if there is heterogeneity of treatment effect based on imaging modality. The primary outcome is the distribution of 90-day mRS scores, with secondary outcomes including functional independence rate, safety, and imaging outcomes. The SELECT2 trial may provide randomized evidence to expand endovascular thrombectomy eligibility to a larger population.

INTERNATIONAL JOURNAL OF STROKE (2022)

Editorial Material Neuroimaging

Selection criteria for large core trials: rationale for the ANGEL-ASPECT study design

Zeguang Ren et al.

JOURNAL OF NEUROINTERVENTIONAL SURGERY (2022)

Review Clinical Neurology

Mechanical Thrombectomy in Patients with a Large Ischemic Volume at Presentation: Systematic Review and Meta-Analysis

Basile Kerleroux et al.

Summary: The study revealed that mechanical thrombectomy (MT) treatment in patients with acute ischemic stroke significantly decreased the risk of unfavorable functional outcomes at 90 days and also reduced mortality rates.

JOURNAL OF STROKE (2021)

Editorial Material Neuroimaging

Select wisely: the ethical challenge of defining large core with perfusion in the early time window

Ashutosh P. Jadhav et al.

JOURNAL OF NEUROINTERVENTIONAL SURGERY (2021)

Editorial Material Neuroimaging

SELECTion criteria for large core trials: dogma or data?

Amrou Sarraj et al.

JOURNAL OF NEUROINTERVENTIONAL SURGERY (2021)

Article Clinical Neurology

Perfusion Imaging and Clinical Outcome in Acute Ischemic Stroke with Large Core

Pierre Seners et al.

Summary: Mechanical thrombectomy (MT) may benefit acute stroke patients with large core when perfusion imaging shows a higher amount of penumbra. The study suggests that perfusion imaging can help identify which patients are suitable for MT based on the amount of salvageable tissue. Further randomized studies are needed to confirm these findings.

ANNALS OF NEUROLOGY (2021)

Article Clinical Neurology

Thrombectomy in Extensive Stroke May Not Be Beneficial and Is Associated With Increased Risk for Hemorrhage

Lukas Meyer et al.

Summary: This study evaluates the benefit of endovascular treatment (EVT) for patients with extensive baseline stroke compared with best medical treatment, finding that EVT may not be beneficial for low Alberta Stroke Program Early CT Score anterior circulation stroke patients, especially in the elderly. However, first- or second-pass complete recanalization seems to reveal a clinical benefit of EVT, highlighting the vulnerability of the low Alberta Stroke Program Early CT Score subgroup.

STROKE (2021)

Article Medicine, General & Internal

Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging

G. W. Albers et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Medicine, General & Internal

Endovascular Therapy for Ischemic Stroke with Perfusion-Imaging Selection

B. C. V. Campbell et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)