Inhibitors of soluble epoxide hydrolase on acute lung injury: a meta-analysis of preclinical studies

Introduction This study investigated the effects of soluble epoxide hydrolase (sEH) inhibitors on acute lung injury (ALI) using the measure of meta-analysis. Methods Relative publications were systematic reviewed and retrieved by searching electronic databases including the Cochrane Library, PubMed, China National Knowledge Infrastructure, Wanfang Data, and Google Scholar. Results Seven animal studies were included in this meta-analysis. Our result showed that the lung injury scores (SMD = - 2.31, 95% CI - 3.50 to - 1.12) and lung wet to dry weight ratios (WMD-1.44, 95% CI - 1.69 to - 1.18) were reduced in sEH inhibitors-treated animals compared with control. The mortality was improved by sEH inhibitors at 48 h (RR = 0.62, 95% CI 0.42 to 0.92), 72 h, and 120 h, but not at 24 h (RR = 0.59, 95% CI 0.35 to 1.01) and 96 h, after induction of ALI model. Conclusions The sEH inhibitor is a potent candidate of pharmacological agents for ALI/acute respiratory distress syndrome, as its effects on improvement of lung injury and mortality in preclinical researches.

Automated summary

This study investigated the effects of sEH inhibitors on ALI using meta-analysis. The results showed that sEH inhibitors can reduce lung injury scores and lung wet to dry weight ratios in animal models. The study also found that the mortality rate was improved by sEH inhibitors after 48 hours, 72 hours, and 120 hours, but not at 24 hours and 96 hours.