The association between cerebrospinal ferritin and soluble triggering receptor expressed on myeloid cells 2 along Alzheimer's continuum

Article Engineering, Biomedical

Precise gene delivery systems with detachable albumin shell remodeling dysfunctional microglia by TREM2 for treatment of Alzheimer's disease

Pengzhen Wang et al.

Summary: The microglia-targeted gene delivery system presented in this study provides a promising approach for Alzheimer's disease therapy by reversing dysfunctional microglia and improving cognitive function.

BIOMATERIALS (2022)

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Article Clinical Neurology

Regional brain iron associated with deterioration in Alzheimer's disease: A large cohort study and theoretical significance

Scott Ayton et al.

Summary: This paper proposes an updated version of the iron hypothesis in Alzheimer's disease, suggesting that brain iron levels are associated with disease progression and may play a role in neurodegeneration. Further research is needed to validate the hypothesis.

ALZHEIMERS & DEMENTIA (2021)

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Article Clinical Neurology

Association of CSF sTREM2, a marker of microglia activation, with cholinergic basal forebrain volume in major depressive disorder

Stefan Teipel et al.

Summary: The study found an association between lower CSF sTREM2 levels at 3 years follow up and MDD, indicating a potential link to central cholinergic system integrity. Limitations included a relatively small sample size and inability to stratify effects for different antidepressant treatments.

JOURNAL OF AFFECTIVE DISORDERS (2021)

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Article Neurosciences

Iron loading is a prominent feature of activated microglia in Alzheimer's disease patients

Boyd Kenkhuis et al.

Summary: Brain iron accumulation accelerates disease progression in Alzheimer patients with amyloid-beta. Activated microglia with increased iron accumulation influence the functional phenotype of cells, especially in conjunction with amyloid-beta. Spatial analysis showed that iron-accumulating microglia predominantly infiltrated A beta-plaques in the brain.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2021)

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Article Neurosciences

TREM2 stems the flow of AD pathology

Katherine Whalley

NATURE REVIEWS NEUROSCIENCE (2021)

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Article Multidisciplinary Sciences

Iron activates microglia and directly stimulates indoleamine-2,3-dioxygenase activity in the N171-82Q mouse model of Huntington's disease

David W. Donley et al.

Summary: This study demonstrates that dietary iron is an important activator of microglia and the KP pathway in the HD model, partially through a direct effect on IDO. Neonatal iron supplementation can promote neurodegeneration and result in additional microglial activation in adults, altering KP metabolite profiles and promoting HD neurodegeneration.

PLOS ONE (2021)

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Article Neurosciences