4.8 Article

Improved intratumoral penetration of IL12 immunocytokine enhances the antitumor efficacy

Related references

Note: Only part of the references are listed.
Review Oncology

Harnessing cytokines and chemokines for cancer therapy

David J. Propper et al.

Summary: Cytokines play a crucial role in cancer development and progression. While cytokines have been studied for their therapeutic potential in oncology, clinical trials have shown limited efficacy. However, the advent of immunotherapies and a better understanding of the tumor microenvironment have opened up new possibilities for harnessing cytokine networks in cancer treatment.

NATURE REVIEWS CLINICAL ONCOLOGY (2022)

Review Pharmacology & Pharmacy

Therapeutic antibodies - natural and pathological barriers and strategies to overcome them

Yara Al Ojaimi et al.

Summary: Antibody-based therapeutics have become an important class of drugs, with over 120 recombinant antibodies approved or under review. The field of antibody therapy is expected to grow rapidly in 2021-2022, fueled by the global response to the SARS-CoV2 pandemic and the disclosure of numerous anti-SARS-CoV2 antibodies. In addition to intravenous delivery, alternative routes of administration have been developed to enhance therapeutic efficacy and patient comfort. Understanding the barriers antibodies face upon entering the body is essential for optimizing their delivery and improving treatment outcomes.

PHARMACOLOGY & THERAPEUTICS (2022)

Review Pharmacology & Pharmacy

Engineering interferons and interleukins for cancer immunotherapy

Patrick G. Holder et al.

Summary: Cytokines are potent immunoregulatory proteins that play important roles in cancer and have the potential for cancer immunotherapy. However, the use of cytokines as therapeutics has been limited by their complex biology and toxicities. Recent advances in immune checkpoint inhibitors and combination immunotherapies have reinvigorated interest in cytokines as therapeutics.

ADVANCED DRUG DELIVERY REVIEWS (2022)

Article Chemistry, Multidisciplinary

Intratumoral delivery of IL-12 and IL-27 mRNA using lipid nanoparticles for cancer immunotherapy

Jin-Qing Liu et al.

Summary: Localized therapy that delivers immune stimulatory cytokines directly to tumors improves therapeutic efficacy without causing systemic toxicity.

JOURNAL OF CONTROLLED RELEASE (2022)

Article Biochemistry & Molecular Biology

Antibody-mediated delivery of a viral MHC-I epitope into the cytosol of target tumor cells repurposes virus-specific CD8+ T cells for cancer immunotherapy

Keunok Jung et al.

Summary: A new antibody technology has been developed to deliver viral epitopes into tumor cells, aiding immune cells to more effectively attack tumor cells.

MOLECULAR CANCER (2022)

Article Biotechnology & Applied Microbiology

A highly stable human single-domain antibody-drug conjugate exhibits superior penetration and treatment of solid tumors

Yanling Wu et al.

Summary: This study reports the identification of a fully human single-domain antibody (UdAb), n501, which shows high stability and strong tumor penetration. The findings suggest that UdAb-based antibody-drug conjugates have the potential to be effective antitumor therapeutics for solid tumors.

MOLECULAR THERAPY (2022)

Article Immunology

Engineering of Humanized Antibodies Against Human Interleukin 5 Receptor Alpha Subunit That Cause Potent Antibody-Dependent Cell-Mediated Cytotoxicity

Jung-Eun Kim et al.

Summary: Patients with severe eosinophilic asthma often experience frequent exacerbations, but targeting IL-5 and IL-5 receptor alpha with antibodies has shown promise in controlling eosinophilia. A new humanized anti-IL-5R alpha Ab, with stronger affinity and potent biological activity compared to a clinically relevant benralizumab analogue, has been developed as a potential alternative therapy for SEA.

FRONTIERS IN IMMUNOLOGY (2021)

Review Pharmacology & Pharmacy

Engineered antibody fusion proteins for targeted disease therapy

Aliyah B. Silver et al.

Summary: Since the approval of the first therapeutic antibody by FDA 35 years ago, antibody-based products have become increasingly important in the pharmaceutical market. Recent efforts have focused on genetically fusing antibodies to disease-relevant payloads, such as cytokines, toxins, enzymes, neuroprotective agents, and soluble factor traps, to enable targeted delivery of therapeutic payloads. With numerous antibody fusion proteins in clinical trials and new innovative molecules on the horizon, these potent and multifunctional drug candidates are expected to play a significant role in therapeutic development for years to come.

TRENDS IN PHARMACOLOGICAL SCIENCES (2021)

Article Multidisciplinary Sciences

Dissecting the impact of target-binding kinetics of protein binders on tumor localization

Yunjin Song et al.

Summary: The study investigates the influence of protein binding affinity on tumor localization, highlighting the importance of optimal affinity for deep penetration into tumors. The debate over establishing a relationship between binding affinity and tumor localization still exists.

ISCIENCE (2021)

Review Immunology

NHS-IL12, a Tumor-Targeting Immunocytokine

John W. Greiner et al.

Summary: NHS-IL12 is a novel immunocytokine designed to deliver IL-12 to the tumor microenvironment, demonstrating enhanced tumor-targeting ability and prolonged half-life compared to rIL-12. It outperforms rIL-12 in enhancing immune cell activation, reducing suppressive myeloid cells, and coordinating host immunity to effectively inhibit tumor growth. Preclinical studies have shown increased anti-tumor efficacy when NHS-IL12 is combined with other immunotherapies or chemotherapy.

IMMUNOTARGETS AND THERAPY (2021)

Review Pharmacology & Pharmacy

Engineering Strategies for Immunomodulatory Cytokine Therapies: Challenges and Clinical Progress

Ivan S. Pires et al.

Summary: Cytokines play a significant role in therapy, but their pleiotropic action and local activity characteristics limit their administration through systemic routes. Various molecular and formulation engineering strategies are currently being applied to reduce treatment toxicity and maintain efficacy.

ADVANCED THERAPEUTICS (2021)

Review Chemistry, Medicinal

Critical Issues in the Development of Immunotoxins for Anticancer Therapy

Ji-Sun Kim et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2020)

Review Pharmacology & Pharmacy

Antibody-cytokine fusion proteins: Biopharmaceuticals with immunomodulatory properties for cancer therapy

Cornelia Hutmacher et al.

ADVANCED DRUG DELIVERY REVIEWS (2019)

Article Medicine, Research & Experimental

ABodyBuilder: Automated antibody structure prediction with data-driven accuracy estimation

Jinwoo Leem et al.

Article Multidisciplinary Sciences

Antigen specificity can be irrelevant to immunocytokine efficacy and biodistribution

Alice Tzeng et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Review Respiratory System

Evidence for the efficacy and safety of anti-interleukin-5 treatment in the management of refractory eosinophilic asthma

Bart Hilvering et al.

THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE (2015)

Review Biochemistry & Molecular Biology

New insights into IL-12-mediated tumor suppression

S. Tugues et al.

CELL DEATH AND DIFFERENTIATION (2015)

Article Oncology

The immunocytokine NHS-IL12 as a potential cancer therapeutic

Jonathan Fallon et al.

ONCOTARGET (2014)

Review Pharmacology & Pharmacy

Immunocytokines: a review of molecules in clinical development for cancer therapy

Thomas List et al.

CLINICAL PHARMACOLOGY-ADVANCES AND APPLICATIONS (2013)

Article Immunology

Crosstalk between Human IgG Isotypes and Murine Effector Cells

Marije B. Overdijk et al.

JOURNAL OF IMMUNOLOGY (2012)

Review Immunology

IL-12 family cytokines: immunological playmakers

Dario A. A. Vignali et al.

NATURE IMMUNOLOGY (2012)

Review Pharmacology & Pharmacy

Antibody tumor penetration: Transport opposed by systemic and antigen-mediated clearance

Greg M. Thurber et al.

ADVANCED DRUG DELIVERY REVIEWS (2008)