Evidence for the heterologous benefits of prior BCG vaccination on COVISHIELD™ vaccine-induced immune responses in SARS-CoV-2 seronegative young Indian adults

Article Infectious Diseases

Effectiveness of ChAdOx1 nCoV-19 vaccine against SARS-CoV-2 infection during the delta (B.1.617.2) variant surge in India: a test-negative, case-control study and a mechanistic study of post-vaccination immune responses

Ramachandran Thiruvengadam et al.

Summary: The ChAdOx1 nCoV-19 vaccine remains effective against the Delta variant and maintains spike-specific T-cell responses. The vaccine shows good effectiveness in preventing moderate-to-severe COVID-19.

LANCET INFECTIOUS DISEASES (2022)

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Review Immunology

The T cell immune response against SARS-CoV-2

Paul Moss

Summary: T cell immunity plays a central role in controlling SARS-CoV-2 infection, with early responses correlating with protection. T cell memory provides broad recognition of viral proteins, limiting the impact of viral variants and offering protection against severe disease. Current COVID-19 vaccines elicit robust T cell responses, contributing to the prevention of hospitalization or death. Therefore, the importance of T cell immunity may have been underestimated.

NATURE IMMUNOLOGY (2022)

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Article Multidisciplinary Sciences

Heterologous vaccination interventions to reduce pandemic morbidity and mortality: Modeling the US winter 2020 COVID-19 wave

Nathaniel Hupert et al.

Summary: COVID-19 remains a global health threat, and non-COVID-19 vaccines may have nonspecific effects that enhance population immunity and provide some protection against SARS-CoV-2 infection. Mathematical modeling suggests that heterologous vaccine interventions could reduce the spread and mortality of COVID-19, and these findings may be applicable to future viral pandemics.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

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Article Immunology

Influence of Aerosol Delivered BCG Vaccination on Immunological and Disease Parameters Following SARS-CoV-2 Challenge in Rhesus Macaques

Andrew D. White et al.

Summary: The aerosol delivery of Bacille Calmette-Guerin (BCG) vaccine enhances innate immune mechanisms and non-conventional T-cell populations, providing cross-protection against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. However, aerosol BCG vaccination does not enhance initial virus clearance or reduce early disease pathology after high-dose SARS-CoV-2 challenge.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Immunology

Large-Scale Structure-Based Screening of Potential T Cell Cross-Reactivities Involving Peptide-Targets From BCG Vaccine and SARS-CoV-2

Renata Fioravanti Tarabini et al.

Summary: The COVID-19 pandemic caused by the SARS-CoV-2 coronavirus has resulted in over 4.5 million deaths worldwide. Despite the development of vaccines, the virus continues to spread globally due to resistance to vaccination and limited access to vaccines. Developing additional therapeutic strategies is crucial to combat SARS-CoV-2 and other coronaviruses.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Nanoscience & Nanotechnology

Designing spatial and temporal control of vaccine responses

Gillie A. Roth et al.

Summary: Vaccines are crucial in combating infectious diseases, but improving the potency and durability of vaccine responses remains a challenge. Material platforms can enhance immune responses by controlling the interactions between vaccine components and immune cells in terms of both spatial and temporal aspects, aiming to induce enhanced memory immunity for future protection.

NATURE REVIEWS MATERIALS (2022)

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Article Medicine, General & Internal

Heterologous ChAdOx1 nCoV-19 and BNT162b2 prime-boost vaccination elicits potent neutralizing antibody responses and T cell reactivity against prevalent SARS-CoV-2 variants

Ruediger Gross et al.

Summary: According to a study on a cohort of individuals who received heterologous ChAdOx1 nCoV-19 BNT162b2 vaccination, the regimen induced potent humoral and cellular immune responses, with strong neutralization of the most prevalent SARS-CoV-2 variants. The results suggest that this heterologous vaccination regimen is at least as immunogenic and protective as homologous vaccinations and also offers protection against current variants of concern.

EBIOMEDICINE (2022)

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Article Immunology

The Association of Previous Vaccination with Live-Attenuated Varicella Zoster Vaccine and COVID-19 Positivity: An Israeli Population-Based Study

Eugene Merzon et al.

Summary: This study found a significant negative association between receiving the live attenuated Varicella Zoster vaccine and the likelihood of COVID-19 infection. The association was particularly strong for individuals aged 50 years and above, indicating that the vaccine could effectively reduce the risk of COVID-19 infection in this age group.

VACCINES (2022)

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Article Multidisciplinary Sciences

Broad anti-SARS-CoV-2 antibody immunity induced by heterologous ChAdOx1/mRNA-1273 vaccination

Chengzi Kaku et al.

Summary: Heterologous prime-boost immunization strategies have the potential to enhance the efficacy of COVID-19 vaccines. A study found that heterologous vaccination induced stronger neutralizing antibody and memory B cell responses, as well as better efficacy against variant strains. The study also revealed that heterologous vaccination can enhance the quality of B cell responses.

SCIENCE (2022)

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Review Cell Biology

Count on us: T cells in SARS-CoV-2 infection and vaccination

Katherine Kedzierska et al.

Summary: This article discusses epitope-specific CD8(+) and CD4(+) T cell responses to SARS-CoV-2 infection and vaccination, their persistence in long-term memory, and their role in limiting disease severity.

CELL REPORTS MEDICINE (2022)

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Review Immunology

The Intersection of Epigenetics and Metabolism in Trained Immunity

Stephanie Fanucchi et al.

Summary: Recent research has shown that innate immune cells can also exhibit immune memory characteristics, termed trained immunity. Trained immunity is involved in infections, vaccination, and inflammatory diseases, and is based on the epigenetic and metabolic reprogramming of cells.

IMMUNITY (2021)

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Article Medicine, Research & Experimental

BCG vaccination history associates with decreased SARS-CoV-2 seroprevalence across a diverse cohort of health care workers

Magali Noval Rivas et al.

Summary: In this study of healthcare workers, those with a history of BCG vaccination had lower seroprevalence of anti-SARS-CoV-2 IgG and reported fewer COVID-19-related symptoms compared to those without BCG vaccination. This suggests a potential protective effect of BCG vaccination against SARS-CoV-2 infection, warranting further large-scale clinical trials for confirmation.

JOURNAL OF CLINICAL INVESTIGATION (2021)

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Article Medicine, General & Internal

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

Merryn Voysey et al.

Summary: The ChAdOx1 nCoV-19 vaccine has been shown to have an acceptable safety profile and effectiveness against symptomatic COVID-19, with higher efficacy observed in the group that received a low dose followed by a standard dose.

LANCET (2021)

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Article Biochemistry & Molecular Biology

T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial

Katie J. Ewer et al.

Summary: A single dose of the ChAdOx1 nCoV-19 vaccine can induce favorable immune responses that may help control or prevent SARS-CoV-2 infection.

NATURE MEDICINE (2021)

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Article Biochemistry & Molecular Biology

Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses

Jordan R. Barrett et al.

Summary: The study demonstrates that a booster dose of ChAdOx1 nCoV-19 is safer and better tolerated than priming doses. The booster dose significantly enhances anti-spike neutralizing antibody titers and other functional antibody responses. These data support the two-dose vaccine regime currently being evaluated in phase 3 clinical trials.

NATURE MEDICINE (2021)

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Article Immunology

Intravenous administration of BCG protects mice against lethal SARS-CoV-2 challenge

Kerry L. Hilligan et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

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Article Medical Laboratory Technology

Evaluation of the automated LIAISON (R) SARS-CoV-2 TrimericS IgG assay for the detection of circulating antibodies

Fabrizio Bonelli et al.

Summary: COVID-19 has led to an influx of tests from various manufacturers, with immunoassays playing a key role in epidemiological studies, longitudinal immunity understanding, and vaccine development. Evaluation of the LIAISON (R) SARS-CoV-2 TrimericS IgG assay demonstrated high sensitivity and specificity, making it suitable for use in high prevalence populations.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2021)

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Article Cell Biology

AZD1222/ChAdOx1 nCoV-19 vaccination induces a polyfunctional spike protein-specific TH1 response with a diverse TCR repertoire

Phillip A. Swanson et al.

Summary: AZD1222 vaccine induces effective T cell responses in adults of all age groups, mainly of T(H)1 type, covering the SARS-CoV-2 spike protein. Vaccination with AZD1222 promotes immune responses and demonstrates broad immunological protection coverage across age groups.

SCIENCE TRANSLATIONAL MEDICINE (2021)

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Article Multidisciplinary Sciences

Exploratory analysis of immunization records highlights decreased SARS-CoV-2 rates in individuals with recent non-COVID-19 vaccinations

Colin Pawlowski et al.

Summary: Clinical studies are being conducted to evaluate the potential of existing vaccines in providing protection against SARS-CoV-2 through trained immunity. Analysis of immunization records from 137,037 individuals who underwent SARS-CoV-2 PCR tests revealed associations between various vaccines and decreased infection rates, with a significant reduction among black individuals who received the PCV13 vaccine.

SCIENTIFIC REPORTS (2021)

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Review Immunology

The BCG Vaccine for COVID-19: First Verdict and Future Directions

Maria Gonzalez-Perez et al.

Summary: Despite the rapid development of SARS-CoV-2 vaccines, widespread vaccination will take time, making BCG a potential interim solution in mitigating the pandemic impact in some countries; the cross-protective effects of BCG vaccine and its mechanism of trained immunity provide potential applications in respiratory infectious diseases and ongoing SARS-CoV-2 clinical trials.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Microbiology

Induction of trained immunity by influenza vaccination-impact on COVID-19

Priya Debisarun et al.

Summary: Influenza vaccination has been shown to reduce the risk of COVID-19 infection by decreasing systemic inflammation and reprogramming immune cells to fight against SARS-CoV-2. This suggests potential benefits of influenza vaccination against COVID-19, calling for future randomized trials to test this possibility.

PLOS PATHOGENS (2021)

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Review Immunology

A century of BCG: Impact on tuberculosis control and beyond*

Asma Ahmed et al.

Summary: BCG vaccine, despite not being perfect, has made significant contributions to the eradication and prevention of tuberculosis. Ongoing research for newer TB vaccines continues, while the potential of BCG in TB prevention remains of great interest.

IMMUNOLOGICAL REVIEWS (2021)

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Article Cell Biology

Effect of BCG Revaccination on Occupationally Exposed Medical Personnel Vaccinated against SARS-CoV-2

Espiridion Ramos-Martinez et al.

Summary: The production of specific neutralizing antibodies by individuals plays a crucial role in reducing severe COVID-19 cases, and revaccination with BCG was found to have a positive impact on the response to the SARS-CoV-2 vaccine, leading to increased neutralizing antibody titers and serum cytokine concentrations.

CELLS (2021)

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Article Immunology

A single dose, BCG-adjuvanted COVID-19 vaccine provides sterilising immunity against SARS-CoV-2 infection

Claudio Counoupas et al.

Summary: This study demonstrates the potential of a BCG-based vaccine to provide protection against major SARS-CoV-2 variants by inducing potent virus-specific immune responses. Pre-treatment with BCG:CoVac followed by a heterologous vaccine boosts SARS-CoV-2-specific antibody responses effectively neutralizing key variants.

NPJ VACCINES (2021)

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Article Medicine, General & Internal

Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 variant of concern 202012/01 (B.1.1.7): an exploratory analysis of a randomised controlled trial

Katherine R. W. Emary et al.

Summary: A post-hoc analysis was conducted on the efficacy of the ChAdOx1 nCoV-19 vaccine against the B.1.1.7 variant of SARS-CoV-2 in the UK. The vaccine showed reduced neutralisation activity against the B.1.1.7 variant in vitro, but still demonstrated efficacy against the B.1.1.7 variant of the virus.

LANCET (2021)

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Review Immunology

SARS-CoV-2-specific T cells in infection and vaccination

Antonio Bertoletti et al.

Summary: Virus-specific T cells during SARS-CoV-2 infection can play a dual role in either protection or pathogenesis, highlighting the importance of studying the function of these cells for future therapeutic and preventative strategies.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

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Review Immunology

COVID-19 pandemic: SARS-CoV-2 specific vaccines and challenges, protection via BCG trained immunity, and clinical trials

Wenping Gong et al.

Summary: This study reviewed the concept and mechanisms of trained immunity induced by the BCG vaccine and presented details of current BCG vaccine clinical trials. The advantages of the BCG vaccine may be essential in overcoming the challenges faced by COVID-19 vaccines.

EXPERT REVIEW OF VACCINES (2021)

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Article Medicine, General & Internal

Safety and immunogenicity of heterologous versus homologous prime-boost schedules with an adenoviral vectored and mRNA COVID-19 vaccine (Com-COV): a single-blind, randomised, non-inferiority trial

Xinxue Liu et al.

Summary: Heterologous prime-boost COVID-19 vaccine schedules could facilitate mass immunisation, with ChAd/BNT showing non-inferior immunogenicity compared to ChAd/ChAd, but BNT/ChAd did not demonstrate non-inferiority to BNT/BNT. The results support flexibility in using heterologous prime-boost vaccination with ChAd and BNT COVID-19 vaccines.

LANCET (2021)

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Article Infectious Diseases

The effect of BCG revaccination on all-cause mortality beyond infancy: 30-year follow-up of a population-based, double-blind, randomised placebo-controlled trial in Malawi

Judith R. Glynn et al.

Summary: The study found little evidence of any beneficial effect of BCG revaccination on all-cause mortality. The high proportion of deaths attributable to non-infectious causes beyond infancy, and the long time interval since BCG for most deaths, might obscure any benefits.

LANCET INFECTIOUS DISEASES (2021)

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Article Biochemistry & Molecular Biology

Immunogenicity and reactogenicity of heterologous ChAdOx1 nCoV-19/mRNA vaccination

Tina Schmidt et al.

Summary: In healthy adults, vaccination with an mRNA vaccine as a booster, regardless of the initial vaccine, resulted in higher levels of spike-specific antibodies and T cells compared to booster vaccination with ChAdOx1 nCov-19. Heterologous vaccination with ChAdOx1 nCoV-19 followed by an mRNA vaccine induced strong immune responses with acceptable reactogenicity, showing similar or better effects than homologous mRNA vaccine regimens.

NATURE MEDICINE (2021)

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Article Biochemistry & Molecular Biology

Immune responses against SARS-CoV-2 variants after heterologous and homologous ChAdOx1 nCoV-19/BNT162b2 vaccination

Joana Barros-Martins et al.

Summary: A study found that booster vaccination with BNT162b2 in healthcare professionals previously vaccinated with ChAdOx-1 nCoV-19 elicited more neutralizing antibodies and higher frequencies of virus-specific T cells. Additionally, BNT162b2 induced high titers of neutralizing antibodies against variants of concern, such as B.1.1.7, B.1.351, and P.1.

NATURE MEDICINE (2021)

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Article Immunology

Recent MMR vaccination in health care workers and Covid-19: A test negative case-control study

Lisa Lundberg et al.

Summary: The study suggests a potential protective effect of the MMR vaccine against SARSCoV-2, especially in males, based on a test negative case-control study during a recent measles outbreak.

VACCINE (2021)

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Review Immunology

The Effects of Trained Innate Immunity on T Cell Responses; Clinical Implications and Knowledge Gaps for Future Research

Dearbhla M. Murphy et al.

Summary: Trained immunity, also known as innate immune training, involves the medium-term epigenetic and metabolic reprogramming of innate immune cells in response to an initial challenge, resulting in altered responses to subsequent challenges. It can lead to increased production of proinflammatory mediators, affect T cell responses, and create a new immune pattern that interacts with adaptive immunity.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Immunology

Oral Polio Vaccine to Protect Against COVID-19: Out of the Box Strategies?

Melanie Malave Sanchez et al.

Summary: The global COVID-19 pandemic has posed challenges in implementing rapid and broad strategies to control the spread of the virus. Utilizing attenuated vaccines, such as the oral polio vaccine, may provide a safe and effective means to protect against respiratory pathogens and curb the pandemic.

OPEN FORUM INFECTIOUS DISEASES (2021)

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Letter Biotechnology & Applied Microbiology

The nf-core framework for community-curated bioinformatics pipelines

Philip A. Ewels et al.

NATURE BIOTECHNOLOGY (2020)

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Review Biochemistry & Molecular Biology

Trained Immunity: a Tool for Reducing Susceptibility to and the Severity of SARS-CoV-2 Infection

Mihai G. Netea et al.

CELL (2020)

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Article Biochemistry & Molecular Biology

A serological assay to detect SARS-CoV-2 seroconversion in humans

Fatima Amanat et al.

NATURE MEDICINE (2020)

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Article Medicine, General & Internal

Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial

Pedro M. Folegatti et al.

LANCET (2020)

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Article Biochemistry & Molecular Biology

Activate: Randomized Clinical Trial of BCG Vaccination against Infection in the Elderly

Evangelos J. Giamarellos-Bourboulis et al.

CELL (2020)

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Article Infectious Diseases

Detection of neutralising antibodies to SARS-CoV-2 to determine population exposure in Scottish blood donors between March and May 2020

Craig P. Thompson et al.

EUROSURVEILLANCE (2020)

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Article Multidisciplinary Sciences

COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses

Ugur Sahin et al.

NATURE (2020)

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Article Microbiology

Comparative assessment of multiple COVID-19 serological technologies supports continued evaluation of point-of-care lateral flow assays in hospital and community healthcare settings

Suzanne Pickering et al.

PLOS PATHOGENS (2020)

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Article Microbiology

Longitudinal observation and decline of neutralizing antibody responses in the three months following SARS-CoV-2 infection in humans

Jeffrey Seow et al.

NATURE MICROBIOLOGY (2020)

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Article Medicine, General & Internal

Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial

Maheshi N. Ramasamy et al.

LANCET (2020)

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Article Cell Biology

BCG Vaccination Induces Long-Term Functional Reprogramming of Human Neutrophils

Simone J. C. F. M. Moorlag et al.

CELL REPORTS (2020)

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Article Multidisciplinary Sciences

Protection against SARS-CoV-2 by BCG vaccination is not supported by epidemiological analyses

Janine Hensel et al.

SCIENTIFIC REPORTS (2020)

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Article Cell Biology

Safety and COVID-19 Symptoms in Individuals Recently Vaccinated with BCG: a Retrospective Cohort Study

Simone J. C. F. M. Moorlag et al.

CELL REPORTS MEDICINE (2020)

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Article Infectious Diseases

Differential effects of BCG vaccine on immune responses induced by vi polysaccharide typhoid fever vaccination: an explorative randomized trial

Bastiaan A. Blok et al.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2020)

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Review Immunology

Defining trained immunity and its role in health and disease

Mihai G. Netea et al.

NATURE REVIEWS IMMUNOLOGY (2020)

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Review Infectious Diseases

Non-specific effects of BCG vaccine on viral infections

S. J. C. F. M. Moorlag et al.

CLINICAL MICROBIOLOGY AND INFECTION (2019)

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Article Immunology

The influence of neonatal Bacille Calmette-Guerin (BCG) immunisation on heterologous vaccine responses in infants

Petra Zimmermann et al.

VACCINE (2019)

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Review Immunology

BCG-Induced Cross-Protection and Development of Trained Immunity: Implication for Vaccine Design

Camila Covian et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Multidisciplinary Sciences

Trained immunity modulates inflammation-induced fibrosis

Mohamed Jeljeli et al.

NATURE COMMUNICATIONS (2019)

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Article Medicine, Research & Experimental

BCG revaccination boosts adaptive polyfunctional Th1/Th17 and innate effectors in IGRA+ and IGRA- Indian adults

Srabanti Rakshit et al.

JCI INSIGHT (2019)

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Article Microbiology

BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity

Rob J. W. Arts et al.

CELL HOST & MICROBE (2018)

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Review Immunology

The influence of BCG on vaccine responses - a systematic review

Petra Zimmermann et al.

EXPERT REVIEW OF VACCINES (2018)

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Article Medicine, Research & Experimental

Mycobacterial growth inhibition is associated with trained innate immunity

Simone A. Joosten et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

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Article Medicine, General & Internal

Prevention of M-tuberculosis Infection with H4:IC31 Vaccine or BCG Revaccination

E. Nemes et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

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Review Immunology

Features of effective T Cell-inducing vaccines against Chronic viral infections

Eleni Panagioti et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Review Microbiology

Heterologous effects of infant BCG vaccination: potential mechanisms of immunity

Egle Butkeviciute et al.

FUTURE MICROBIOLOGY (2018)

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Article Biochemistry & Molecular Biology

Induction of Autonomous Memory Alveolar Macrophages Requires T Cell Help and Is Critical to Trained Immunity

Yushi Yao et al.

CELL (2018)

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Article Immunology

Ex-Th17 (Nonclassical Th1) Cells Are Functionally Distinct from Classical Th1 and Th17 Cells and Are Not Constrained by Regulatory T Cells

Sharee A. Basdeo et al.

JOURNAL OF IMMUNOLOGY (2017)

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Letter Biotechnology & Applied Microbiology

Nextflow enables reproducible computational workflows

Paolo Di Tommaso et al.

NATURE BIOTECHNOLOGY (2017)

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Article Multidisciplinary Sciences

Circulating Mycobacterium tuberculosis DosR latency antigen-specific, polyfunctional, regulatory IL10+ Th17 CD4 T-cells differentiate latent from active tuberculosis

Srabanti Rakshit et al.

SCIENTIFIC REPORTS (2017)

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Article Immunology

Early BCG-Denmark and Neonatal Mortality Among Infants Weighing <2500 g: A Randomized Controlled Trial

Sofie Biering-Sorensen et al.

CLINICAL INFECTIOUS DISEASES (2017)

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Article Cell Biology

Immunometabolic Pathways in BCG-Induced Trained Immunity

Rob J. W. Arts et al.

CELL REPORTS (2016)

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Article Immunology

Nonspecific (Heterologous) Protection of Neonatal BCG Vaccination Against Hospitalization Due to Respiratory Infection and Sepsis

Maria Jose de Castro et al.

CLINICAL INFECTIOUS DISEASES (2015)

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Article Biochemical Research Methods

Qualification of a whole blood intracellular cytokine staining assay to measure mycobacteria-specific CD4 and CD8 T cell immunity by flow cytometry

Benjamin M. Kagina et al.

JOURNAL OF IMMUNOLOGICAL METHODS (2015)

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Article Immunology

BCG Vaccination Enhances the Immunogenicity of Subsequent Influenza Vaccination in Healthy Volunteers: A Randomized, Placebo-Controlled Pilot Study

Jenneke Leentjens et al.

JOURNAL OF INFECTIOUS DISEASES (2015)

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Article Multidisciplinary Sciences

An optimised method for the production of MERS-CoV spike expressing viral pseudotypes

K. Grehan et al.

METHODSX (2015)

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Article Immunology

Long-Lasting Effects of BCG Vaccination on Both Heterologous Th1/Th17 Responses and Innate Trained Immunity

Johanneke Kleinnijenhuis et al.

JOURNAL OF INNATE IMMUNITY (2014)

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Article Biotechnology & Applied Microbiology

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love et al.

GENOME BIOLOGY (2014)

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Article Immunology

Non-specific effect of Bacille Calmette-Guerin vaccine on the immune response to routine immunisations

Nicole Ritz et al.

VACCINE (2013)

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Article Multidisciplinary Sciences

Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes

Johanneke Kleinnijenhuis et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

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Article Microbiology

Trained Immunity: A Memory for Innate Host Defense

Mihai G. Netea et al.

CELL HOST & MICROBE (2011)

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Article Biochemical Research Methods

SPICE: Exploration and Analysis of Post-Cytometric Complex Multivariate Datasets

Mario Roederer et al.

CYTOMETRY PART A (2011)

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Editorial Material Medicine, General & Internal

The BCG World Atlas: A Database of Global BCG Vaccination Policies and Practices

Alice Zwerling et al.

PLOS MEDICINE (2011)

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Review Immunology

Vaccine Adjuvants: Putting Innate Immunity to Work

Robert L. Coffman et al.

IMMUNITY (2010)

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Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

Sven Heinz et al.

MOLECULAR CELL (2010)

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Article Virology

CD4 T-Cell-Mediated Heterologous Immunity between Mycobacteria and Poxviruses

Keisha S. Mathurin et al.

JOURNAL OF VIROLOGY (2009)

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Evidence for the heterologous benefits of prior BCG vaccination on COVISHIELD™ vaccine-induced immune responses in SARS-CoV-2 seronegative young Indian adults

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