4.8 Article

The pyroptosis-related gene signature predicts prognosis and indicates the immune microenvironment status of chronic lymphocytic leukemia

Related references

Note: Only part of the references are listed.
Review Oncology

Current and future treatment strategies in chronic lymphocytic leukemia

Krish Patel et al.

Summary: Treatment decisions for patients with chronic lymphocytic leukemia (CLL) are based on symptoms and risk classifications. New therapies targeting specific genetic aberrations have shown promising results, improving outcomes and prolonging progression-free survival. Novel targeted oral therapies have largely replaced chemoimmunotherapy in the treatment of CLL.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

Review Hematology

BCL2 and MCL1 inhibitors for hematologic malignancies

Andrew W. Roberts et al.

Summary: BH3 mimetics are a new class of anticancer drugs that target prosurvival BCL2 proteins to induce apoptosis, with Venetoclax being the first approved BCL2 inhibitor showing activity in various lymphoid and myeloid neoplasms. Long-term exposure may lead to secondary resistance. Success of BCL2 inhibitors has led to development of BH3 mimetics targeting MCL1, with promising preclinical activity but potential challenges due to MCL1's physiological roles in nonhematologic tissues.

BLOOD (2021)

Article Multidisciplinary Sciences

Gasdermin E suppresses tumour growth by activating anti-tumour immunity

Zhibin Zhang et al.

NATURE (2020)

Review Oncology

Ferroptosis, necroptosis, and pyroptosis in anticancer immunity

Rong Tang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

Article Medicine, General & Internal

Venetoclax and Obinutuzumab in Patients with CLL and Coexisting Conditions

K. Fischer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Review Cell Biology

The role of pyroptosis in cancer: pro-cancer or pro-host?

Xiaojing Xia et al.

CELL DEATH & DISEASE (2019)

Review Oncology

Induction of Pyroptosis and Its Implications in Cancer Management

Yan-Yang Wang et al.

FRONTIERS IN ONCOLOGY (2019)

Review Immunology

The NLRP3 inflammasome: molecular activation and regulation to therapeutics

Karen V. Swanson et al.

NATURE REVIEWS IMMUNOLOGY (2019)

Article Oncology

Ferroptosis: A Novel Anti-tumor Action for Cisplatin

Jipeng Guo et al.

CANCER RESEARCH AND TREATMENT (2018)

Article Multidisciplinary Sciences

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

Yupeng Wang et al.

NATURE (2017)

Article Hematology

Chronic lymphocytic leukemia: 2017 update on diagnosis, risk stratification, and treatment

Michael Hallek

AMERICAN JOURNAL OF HEMATOLOGY (2017)

Review Biochemistry & Molecular Biology

Caspases and their substrates

Olivier Julien et al.

CELL DEATH AND DIFFERENTIATION (2017)

Article Education, Scientific Disciplines

Prognostication of chronic lymphocytic leukemia in the era of new agents

Barbara Eichhorst et al.

HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM (2016)

Article Multidisciplinary Sciences

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

Nobuhiko Kayagaki et al.

NATURE (2015)

Article Multidisciplinary Sciences

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

Jianjin Shi et al.

NATURE (2015)

Article Medicine, Research & Experimental

Deregulation of the NLRP3 inflammasome in hepatic parenchymal cells during liver cancer progression

Qing Wei et al.

LABORATORY INVESTIGATION (2014)

Article Biochemical Research Methods

The sva package for removing batch effects and other unwanted variation in high-throughput experiments

Jeffrey T. Leek et al.

BIOINFORMATICS (2012)

Review Biochemistry & Molecular Biology

Caspase Substrates and Cellular Remodeling

Emily D. Crawford et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 80 (2011)

Review Biochemistry & Molecular Biology

The BCL-2 Family Reunion

Jerry E. Chipuk et al.

MOLECULAR CELL (2010)