4.8 Article

Inflammatory activation of the FcγR and IFNγR pathways co-influences the differentiation and activity of osteoclasts

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

Finely-Tuned Calcium Oscillations in Osteoclast Differentiation and Bone Resorption

Hiroyuki Okada et al.

Summary: Calcium oscillations play a crucial role in osteoclast differentiation and function, with various modifiers involved in fine-tuning this process. In addition to traditional factors like M-CSF and RANKL, immunoreceptor-related adaptors' costimulatory signaling is important for calcium oscillation generation. Certain calcium channels and transporters are essential for calcium oscillations in osteoclasts, alongside organelles like lysosomes, mitochondria, and the ER storing intracellular calcium.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Cell Biology

Membrane Transport Proteins in Osteoclasts: The Ins and Outs

Amy B. P. Ribet et al.

Summary: Osteoclasts play a crucial role in bone resorption, maintaining extreme environmental conditions and coordinating the actions of various membrane transport proteins. In addition to well-known key proteins, the contributions of other membrane transport proteins to osteoclast function are still unclear.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Multidisciplinary Sciences

Targeted apoptosis of macrophages and osteoclasts in arthritic joints is effective against advanced inflammatory arthritis

Caifeng Deng et al.

Summary: The study successfully delivered celastrol using enzyme-responsive nanoparticles to induce apoptosis of OCs and macrophages in rheumatoid arthritis joints, reducing inflammation and showing therapeutic effects in a rat model.

NATURE COMMUNICATIONS (2021)

Review Immunology

Fc Gamma Receptors as Regulators of Bone Destruction in Inflammatory Arthritis

Yuyue Zuo et al.

Summary: Studies have shown that Fc gamma receptors play dual roles in bone erosion in inflammatory arthritis, with the potential to serve as therapeutic targets against bone erosion.

FRONTIERS IN IMMUNOLOGY (2021)

Article Medicine, General & Internal

Bone Metabolism and RANKL/OPG Ratio in Rheumatoid Arthritis Women Treated with TNF-α Inhibitors

Agnieszka Jura-Poltorak et al.

Summary: This study demonstrated that anti-TNF-alpha therapy in combination with methotrexate can improve bone metabolism in female patients with RA, leading to a decrease in bone resorption and an increase in bone formation levels. The findings suggest that markers such as PINP and CTX-I may be useful indicators of the effectiveness of TNF-alpha therapy in RA patients.

JOURNAL OF CLINICAL MEDICINE (2021)

Review Biochemistry & Molecular Biology

Membrane trafficking in osteoclasts and implications for osteoporosis

Pei Ying Ng et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2019)

Article Endocrinology & Metabolism

Fra1 Controls Rheumatoid Factor Autoantibody Production by Bone Marrow Plasma Cells and the Development of Autoimmune Bone Loss

Bettina Groetsch et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2019)

Review Immunology

How Autoantibodies Regulate Osteoclast Induced Bone Loss in Rheumatoid Arthritis

Ulrike Steffen et al.

FRONTIERS IN IMMUNOLOGY (2019)

Review Immunology

Multiple Variables at the Leukocyte Cell Surface Impact Fc γ Receptor-Dependent Mechanisms

Kashyap R. Patel et al.

FRONTIERS IN IMMUNOLOGY (2019)

Review Biochemistry & Molecular Biology

Specialized Roles for Actin in Osteoclasts: Unanswered Questions and Therapeutic Opportunities

Guanghong Han et al.

BIOMOLECULES (2019)

Review Immunology

Interferon-Gamma-Mediated Osteoimmunology

Mengjia Tang et al.

FRONTIERS IN IMMUNOLOGY (2018)

Review Immunology

Regulation of Osteoclast Differentiation by Cytokine Networks

Dulshara Sachini Amarasekara et al.

IMMUNE NETWORK (2018)

Review Immunology

The role of anti-citrullinated protein antibodies (ACPA) in the pathogenesis of rheumatoid arthritis

Weronika Kurowska et al.

CENTRAL EUROPEAN JOURNAL OF IMMUNOLOGY (2017)

Review Allergy

A Comprehensive Review of Immunoreceptor Regulation of Osteoclasts

Mary Beth Humphrey et al.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2016)

Article Multidisciplinary Sciences

Immune complexes regulate bone metabolism through FcRγ signalling

Takako Negishi-Koga et al.

NATURE COMMUNICATIONS (2015)

Article Immunology

A role for the ITAM signaling module in specifying cytokine-receptor functions

Jelena S. Bezbradica et al.

NATURE IMMUNOLOGY (2014)

Review Biochemistry & Molecular Biology

Regulation of osteoclasts by membrane-derived lipid mediators

Tsukasa Oikawa et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2013)

Article Medicine, Research & Experimental

Lipopolysaccharide (LPS) promotes osteoclast differentiation and activation by enhancing the MAPK pathway and COX-2 expression in RAW264.7 cells

Guo-Qing Hou et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2013)

Article Medicine, Research & Experimental

Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin

Ulrike Harre et al.

JOURNAL OF CLINICAL INVESTIGATION (2012)

Article Biochemistry & Molecular Biology

Evidence That the Kinase-Truncated c-Src Regulates NF-κB Signaling by Targeting NEMO

S. Dai et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2011)

Article Biochemistry & Molecular Biology

Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals

Masahiro Shinohara et al.

Article Medicine, Research & Experimental

IFN-gamma stimulates osteoclast formation and bone loss in vivo via antigen-driven T cell activation

Yuhao Gao et al.

JOURNAL OF CLINICAL INVESTIGATION (2007)

Review Biochemistry & Molecular Biology

RANKL-RANK signaling in osteoclastogenesis and bone disease

T Wada et al.

TRENDS IN MOLECULAR MEDICINE (2006)

Article Oncology

Reactive oxygen species mediate RANK signaling in osteoclasts

H Ha et al.

EXPERIMENTAL CELL RESEARCH (2004)

Article Biochemistry & Molecular Biology

A RANK/TRAF6-dependent signal transduction pathway is essential for osteoclast cytoskeletal organization and resorptive function

AP Armstrong et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Endocrinology & Metabolism

Dual modulation of osteoclast differentiation by lipopolysaccharide

W Zou et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2002)