Regulatory T cells regulate blastemal proliferation during zebrafish caudal fin regeneration

The role of T cells in appendage regeneration remains unclear. In this study, we revealed an important role for regulatory T cells (Tregs), a subset of T cells that regulate tolerance and tissue repair, in the epimorphic regeneration of zebrafish caudal fin tissue. Upon amputation, fin tissue-resident Tregs infiltrate into the blastema, a population of progenitor cells that produce new fin tissues. Conditional genetic ablation of Tregs attenuates blastemal cell proliferation during fin regeneration. Blastema-infiltrating Tregs upregulate the expression of igf2a and igf2b, and pharmacological activation of IGF signaling restores blastemal proliferation in Treg-ablated zebrafish. These findings further extend our understandings of Treg function in tissue regeneration and repair.

Automated summary

Regulatory T cells (Tregs) play an important role in the epimorphic regeneration of zebrafish caudal fin tissue by infiltrating into the progenitor cell population and upregulating the expression of specific genes to promote tissue repair and cell proliferation.