☆ 4.8 Article

Integrated metabolomics and lipidomics study of patients with atopic dermatitis in response to dupilumab

FRONTIERS IN IMMUNOLOGY (2022)

Related references

Note: Only part of the references are listed.

Editorial Material Dermatology

American Academy of Dermatology Guidelines: Awareness of comorbidities associated with atopic dermatitis in adults

Dawn M. R. Davis et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2022)

Add to Collection

Review Immunology

Phosphatidylcholine-Derived Lipid Mediators: The Crosstalk Between Cancer Cells and Immune Cells

Renata de Freitas Saito et al.

Summary: This review highlights the role of phosphatidylcholine metabolism in cancer therapy resistance, from intracellular processes to cellular communication within the tumor microenvironment, providing new insights for treating drug-resistant cancers.

FRONTIERS IN IMMUNOLOGY (2022)

Add to Collection

Review Biochemistry & Molecular Biology

Atopic Dermatitis: The Fate of the Fat

Petra Pavel et al.

Summary: Atopic dermatitis is a chronic inflammatory skin disease influenced by both genetic and environmental factors. Alterations of the epidermal barrier and lipid abnormalities play crucial roles in the development and inflammation of the disease.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection

Review Biochemistry & Molecular Biology

Role of Branched-Chain Amino Acid Metabolism in Type 2 Diabetes, Obesity, Cardiovascular Disease and Non-Alcoholic Fatty Liver Disease

Paola Cuomo et al.

Summary: Branched-chain amino acids (BCAAs) play an important role in human health. High levels of BCAAs are associated with various metabolic diseases, while low levels are beneficial for metabolic health. However, the exact mechanisms underlying the dysregulation caused by high levels of BCAAs are still under debate.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection

Review Biology

Tricarboxylic Acid (TCA) Cycle Intermediates: Regulators of Immune Responses

Inseok Choi et al.

Summary: The TCA cycle is a series of chemical reactions that occur in the mitochondria of aerobic organisms to generate energy from acetyl-CoA. The intermediates of the TCA cycle may leak from dysfunctional mitochondria and regulate immune responses under cell stress conditions. Increasing evidence suggests that the metabolites of the TCA cycle play important roles in the regulation of immune activation and suppression.

LIFE-BASEL (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Skin lipids in health and disease: A review

Sophie Knox et al.

Summary: Our skin serves as a flexible barrier and plays important roles in protection, immunity, regulation, and sensation. Skin lipids are crucial for maintaining skin structure and function, with various types of lipids playing key roles. Research on skin lipids, including changes in composition related to skin diseases, will pave the way for advancements in diagnosis, prevention, and treatment of skin disorders.

CHEMISTRY AND PHYSICS OF LIPIDS (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Molecular Mechanisms of Atopic Dermatitis Pathogenesis

Jowita Sroka-Tomaszewska et al.

Summary: Atopic dermatitis is a chronic, non-infectious inflammatory skin disease with a complex pathophysiology involving genetic disorders, epidermal barrier defects, immune response alterations, and disruption of skin microbial balance. The disease significantly affects the quality of life of patients and their families, potentially requiring personalized treatment approaches.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Aberrations in Lipid Expression and Metabolism in Psoriasis

Julia Nowowiejska et al.

Summary: Psoriasis is a common skin disease affecting about 1%-3% of the general population, often accompanied by cardiometabolic disorders. Research indicates that lipid expression and metabolism disorders are more common in psoriatic patients, playing a significant role in the pathogenesis of psoriasis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets

Bei Wang et al.

Summary: The arachidonic acid (AA) pathway is crucial in cardiovascular biology, carcinogenesis, and various inflammatory diseases, producing bioactive mediators that are potential targets for cardiovascular diseases, cancers, and inflammatory diseases. This review summarizes the physiological and pathophysiological importance of AA metabolizing pathways, as well as the molecular mechanisms underlying its actions in CVD and cancer progression. Additionally, clinical studies targeting AA metabolisms in different disease conditions are introduced to explore the role of AA metabolism and potential therapies.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Add to Collection

Article Allergy

Dupilumab is very effective in a large cohort of difficult-to-treat adult atopic dermatitis patients: First clinical and biomarker results from the BioDay registry

Lieneke F. M. Ariens et al.

ALLERGY (2020)

Add to Collection

Review Multidisciplinary Sciences

Mitochondrial TCA cycle metabolites control physiology and disease

Inmaculada Martinez-Reyes et al.

NATURE COMMUNICATIONS (2020)

Add to Collection

Article Medicine, General & Internal

Metabolomic Analysis Reveals Distinct Profiles in the Plasma and Urine Associated with IgE Reactions in Childhood Asthma

Chih-Yung Chiu et al.

JOURNAL OF CLINICAL MEDICINE (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Succinate Is an Inflammation-Induced Immunoregulatory Metabolite in Macrophages

Karl J. Harber et al.

METABOLITES (2020)

Add to Collection

Article Dermatology

Transcriptomic and lipidomic profiling of eicosanoid/docosanoid signalling in affected and non-affected skin of human atopic dermatitis patients

Daniel Torocsik et al.

EXPERIMENTAL DERMATOLOGY (2019)

Add to Collection

Article Allergy

A tryptophan metabolite of the skin microbiota attenuates inflammation in patients with atopic dermatitis through the aryl hydrocarbon receptor

Jinlei Yu et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

Add to Collection

Article Nutrition & Dietetics

Urinary organic acids as biomarkers in the assessment of pulmonary function in children with asthma

Maria Michelle Papamichael et al.

NUTRITION RESEARCH (2019)

Add to Collection

Article Allergy

Epidemiology of atopic dermatitis in adults: Results from an international survey

S. Barbarot et al.

ALLERGY (2018)

Add to Collection

Review Biochemistry & Molecular Biology

Branched Chain Amino Acids: Beyond Nutrition Metabolism

Cunxi Nie et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Effects of atopic dermatitis and gender on sebum lipid mediator and fatty acid profiles

Karan Agrawal et al.

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS (2018)

Add to Collection

Article Cell Biology

Gut Microbiota-Derived Tryptophan Metabolites Modulate Inflammatory Response in Hepatocytes and Macrophages

Smitha Krishnan et al.

CELL REPORTS (2018)

Add to Collection

Article Biology

Lipidomics profiling reveals the role of glycerophospholipid metabolism in psoriasis

Chunwei Zeng et al.

GIGASCIENCE (2017)

Add to Collection

Article Multidisciplinary Sciences

Blood serum metabolome of atopic dermatitis: Altered energy cycle and the markers of systemic inflammation

Aigar Ottas et al.

PLOS ONE (2017)

Add to Collection

Review Biochemistry & Molecular Biology

Lipidomics, en route to accurate quantitation

Sin Man Lam et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2017)

Add to Collection

Article Biochemistry & Molecular Biology

Metabolomics Workbench: An international repository for metabolomics data and metadata, metabolite standards, protocols, tutorials and training, and analysis tools

Manish Sud et al.

NUCLEIC ACIDS RESEARCH (2016)

Add to Collection

Article Allergy

Higher maternal serum concentrations of nicotinamide and related metabolites in late pregnancy are associated with a lower risk of offspring atopic eczema at age 12 months

S. El-Heis et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2016)

Add to Collection

Article Allergy

Cellular and molecular immunologic mechanisms in patients with atopic dermatitis

Thomas Werfel et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2016)

Add to Collection

Article Dermatology

Patient burden of moderate to severe atopic dermatitis (AD): Insights from a phase 2b clinical trial of dupilumab in adults

Eric L. Simpson et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2016)

Add to Collection

Article Medicine, General & Internal

Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis

E. L. Simpson et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Add to Collection

Review Immunology

Metabolic regulation by secreted phospholipase A(2)

Hiroyasu Sato et al.

INFLAMMATION AND REGENERATION (2016)

Add to Collection

Article Allergy

Increased efficacy of omalizumab in atopic dermatitis patients with wild-type filaggrin status and higher serum levels of phosphatidylcholines

M. Hotze et al.

ALLERGY (2014)

Add to Collection

Article Dermatology

The importance of free fatty acid chain length for the skin barrier function in atopic eczema patients

Jeroen van Smeden et al.

EXPERIMENTAL DERMATOLOGY (2014)

Add to Collection

Article Biochemical Research Methods

Serum Metabolomics Study and Eicosanoid Analysis of Childhood Atopic Dermatitis Based on Liquid Chromatography-Mass Spectrometry

Yan Huang et al.

JOURNAL OF PROTEOME RESEARCH (2014)

Add to Collection

Article Endocrinology & Metabolism

Altered levels of serum sphingomyelin and ceramide containing distinct acyl chains in young obese adults

H. Hanamatsu et al.

NUTRITION & DIABETES (2014)

Add to Collection

Letter Dermatology

Changes in the Ceramide Profile of Atopic Dermatitis Patients

Junko Ishikawa et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2010)

Add to Collection

Review Urology & Nephrology

Analytical Approaches to Metabolomics and Applications to Systems Biology

Jeffrey H. Wang et al.

SEMINARS IN NEPHROLOGY (2010)

Add to Collection

Article Cell Biology

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

Christopher B. Newgard et al.

CELL METABOLISM (2009)

Add to Collection

Article Allergy

Global variations in prevalence of eczema symptoms in children from ISAAC Phase Three

Joseph A. Odhiambo et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2009)

Add to Collection

Article Allergy

Linoleic acid metabolite levels and transepidermal water loss in children with atopic dermatitis

Chiung-Hui Yen et al.

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2008)

Add to Collection

Review Biochemistry & Molecular Biology

Phosphatidylcholine and choline homeostasis

Zhaoyu Li et al.

JOURNAL OF LIPID RESEARCH (2008)

Add to Collection

Article Chemistry, Analytical

XCMS: Processing mass spectrometry data for metabolite profiling using Nonlinear peak alignment, matching, and identification

CA Smith et al.

ANALYTICAL CHEMISTRY (2006)

Add to Collection

© Peeref 2019-2024. All rights reserved.