MSC-EVs transferring mitochondria and related components: A new hope for the treatment of kidney disease

Kidney disease is a serious hazard to human health. Acute or chronic renal disease will have a significant negative impact on the body's metabolism. The involvement of mitochondria in renal illness has received a lot of interest as research on kidney disease has advanced. Extracellular vesicles are gaining popularity as a means of intercellular communication in recent years. They have a close connection to both the nephropathy process and the intercellular transfer of mitochondria. The goal of this review is to present the extracellular vesicle transport mitochondria and its related biologically active molecules as new therapeutic options for the treatment of clinical kidney disease. This review focuses on the extracellular vesicles through the transfer of mitochondria and its related bioactive molecules, which affect mitochondrial energy metabolism, take part in immune regulation, and secrete outside the body.

Automated summary

Kidney disease poses a significant threat to human health, and research has shown the involvement of mitochondria in renal illness. Extracellular vesicles have emerged as a crucial means of intercellular communication, with a close connection to both the kidney disease process and the transfer of mitochondria. This review explores the potential of using extracellular vesicles to transport mitochondria and its bioactive molecules as a new therapeutic option for clinical kidney disease.