Related references
Note: Only part of the references are listed.TERT activates endogenous retroviruses to promote an immunosuppressive tumour microenvironment
Jian Mao et al.
EMBO REPORTS (2022)
Emerging role of RNA sensors in tumor microenvironment and immunotherapy
Rui Yang et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2022)
ADAR1 masks the cancer immunotherapeutic promise of ZBP1-driven necroptosis
Ting Zhang et al.
NATURE (2022)
Spliceosome-targeted therapies trigger an antiviral immune response in triple-negative breast cancer
Elizabeth A. Bowling et al.
CELL (2021)
Anti-pyroptotic function of TGF-β is suppressed by a synthetic dsRNA analogue in triple negative breast cancer cells
Yusuke Tamura et al.
MOLECULAR ONCOLOGY (2021)
MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells
Xin Yin et al.
CELL REPORTS (2021)
SARS-CoV-2 nsp12 attenuates type I interferon production by inhibiting IRF3 nuclear translocation
Wenjing Wang et al.
CELLULAR & MOLECULAR IMMUNOLOGY (2021)
Profiling of DNA damage and repair pathways in small cell lung cancer reveals a suppressive role in the immune landscape
Renjing Jin et al.
MOLECULAR CANCER (2021)
SARS-CoV-2 Triggers an MDA-5-Dependent Interferon Response Which Is Unable To Control Replication in Lung Epithelial Cells
Antoine Rebendenne et al.
JOURNAL OF VIROLOGY (2021)
Special delivery! CAR-T cells transport RN7SL1 to the tumor microenvironment
W. Sam Nutt et al.
TRENDS IN MOLECULAR MEDICINE (2021)
SARS-CoV-2 ORF9b antagonizes type I and III interferons by targeting multiple components of the RIG-I/MDA-5-MAVS, TLR3-TRIF, and cGAS-STING signaling pathways
Lulu Han et al.
JOURNAL OF MEDICAL VIROLOGY (2021)
SARS-CoV-2 Membrane Protein Inhibits Type I Interferon Production Through Ubiquitin-Mediated Degradation of TBK1
Liyan Sui et al.
FRONTIERS IN IMMUNOLOGY (2021)
ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity
GuanQun Liu et al.
NATURE MICROBIOLOGY (2021)
The immunostimulatory RNA RN7SL1 enables CAR-T cells to enhance autonomous and endogenous immune function
Lexus R. Johnson et al.
CELL (2021)
SARS-CoV-2 sensing by RIG-I and MDA5 links epithelial infection to macrophage inflammation
Lucy G. Thorne et al.
EMBO JOURNAL (2021)
The RNA sensor MDA5 detects SARS-CoV-2 infection
Natalia G. Sampaio et al.
SCIENTIFIC REPORTS (2021)
Nucleic Acid Sensors and Programmed Cell Death
Jonathan Maelfait et al.
JOURNAL OF MOLECULAR BIOLOGY (2020)
The role of DNA-demethylating agents in cancer therapy
Parinaz Mehdipour et al.
PHARMACOLOGY & THERAPEUTICS (2020)
Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding
Roujian Lu et al.
LANCET (2020)
Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19
Daniel Blanco-Melo et al.
CELL (2020)
Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients
Zhuo Zhou et al.
CELL HOST & MICROBE (2020)
Identification of a novel coronavirus causing severe pneumonia in human: a descriptive study
Li-Li Ren et al.
CHINESE MEDICAL JOURNAL (2020)
Inactivation of Fbxw7 Impairs dsRNA Sensing and Confers Resistance to PD-1 Blockade
Cecile Gstalder et al.
CANCER DISCOVERY (2020)
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
David E. Gordon et al.
NATURE (2020)
Spatiotemporal dynamics of innate immune signaling via RIG-I-like receptors
Katharina Esser-Nobis et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)
Epigenetic therapy induces transcription of inverted SINEs and ADAR1 dependency
Parinaz Mehdipour et al.
NATURE (2020)
Rheumatic manifestations of COVID-19: a systematic review and meta-analysis
Jacopo Ciaffi et al.
BMC RHEUMATOLOGY (2020)
Pathogen Molecular Pattern Receptor Agonists: Treating Cancer by Mimicking Infection
Mark Aleynick et al.
CLINICAL CANCER RESEARCH (2019)
Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade
Jeffrey J. Ishizuka et al.
NATURE (2019)
Tumor-derived IFN triggers chronic pathway agonism and sensitivity to ADAR loss
Huayang Liu et al.
NATURE MEDICINE (2019)
Targeting Cytosolic Nucleic Acid-Sensing Pathways for Cancer Immunotherapies
Sandra Iurescia et al.
FRONTIERS IN IMMUNOLOGY (2018)
Mitochondrial double-stranded RNA triggers antiviral signalling in humans
Ashish Dhir et al.
NATURE (2018)
Plasticity of Type I Interferon-Mediated Responses in Cancer Therapy: From Anti-tumor Immunity to Resistance
Megha Budhwani et al.
FRONTIERS IN ONCOLOGY (2018)
Programmed cell death as a defence against infection
Ine Jorgensen et al.
NATURE REVIEWS IMMUNOLOGY (2017)
Importance of Nucleic Acid Recognition in Inflammation and Autoimmunity
Franck J. Barrat et al.
ANNUAL REVIEW OF MEDICINE, VOL 67 (2016)
Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice
Rudragouda Channappanavar et al.
CELL HOST & MICROBE (2016)
Recognition of Endogenous Nucleic Acids by the Innate Immune System
Axel Roers et al.
IMMUNITY (2016)
Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5
Emiko Uchikawa et al.
MOLECULAR CELL (2016)
Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing
Qi Chen et al.
NATURE IMMUNOLOGY (2016)
Viruses and the Diversity of Cell Death
Pranav Danthi
ANNUAL REVIEW OF VIROLOGY, VOL 3 (2016)
DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts
David Roulois et al.
CELL (2015)
Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses
Katherine B. Chiappinelli et al.
CELL (2015)
Viral RNA detection by RIG-I-like receptors
Mitsutoshi Yoneyama et al.
CURRENT OPINION IN IMMUNOLOGY (2015)
Pattern Recognition Receptors in Cancer Progression and Metastasis
Sanjay Pandey et al.
CANCER GROWTH AND METASTASIS (2015)
Aicardi-Goutieres Syndrome Is Caused by IFIH1 Mutations
Hirotsugu Oda et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2014)
Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids
Jiaxi Wu et al.
ANNUAL REVIEW OF IMMUNOLOGY, VOL 32 (2014)
Pancreatic Cancer-Specific Cell Death Induced In Vivo by Cytoplasmic-Delivered Polyinosine-Polycytidylic Acid
Praveen Bhoopathi et al.
CANCER RESEARCH (2014)
Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5′-diphosphates
Delphine Goubau et al.
NATURE (2014)
Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling
Gillian I. Rice et al.
NATURE GENETICS (2014)
Structural Basis for dsRNA Recognition, Filament Formation, and Antiviral Signal Activation by MDA5
Bin Wu et al.
CELL (2013)
Master sensors of pathogenic RNA - RIG-I like receptors
Martin Schlee
IMMUNOBIOLOGY (2013)
Epigenetic cancer therapy: rationales, targets and drugs
M. Rius et al.
ONCOGENE (2012)
Type I interferon is selectively required by dendritic cells for immune rejection of tumors
Mark S. Diamond et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2011)
Prolonged Antigen Storage Endows Merocytic Dendritic Cells with Enhanced Capacity To Prime Anti-Tumor Responses in Tumor-Bearing Mice
Rachel A. Reboulet et al.
JOURNAL OF IMMUNOLOGY (2010)
Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction
Ji Luo et al.
CELL (2009)
Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells
Robert Besch et al.
JOURNAL OF CLINICAL INVESTIGATION (2009)
Activation of MDA5 Requires Higher-Order RNA Structures Generated during Virus Infection
Andreas Pichlmair et al.
JOURNAL OF VIROLOGY (2009)
5′-triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma
Hendrik Poeck et al.
NATURE MEDICINE (2008)
Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125
Kei-ichiro Arimoto et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
5′-triphosphate RNA is the ligand for RIG-I
Veit Hornung et al.
SCIENCE (2006)
Viral and therapeutic control of IFN-β promoter stimulator 1 during hepatitis C virus infection
YM Loo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Pathogen recognition and innate immunity
S Akira et al.
CELL (2006)
Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response
G Oganesyan et al.
NATURE (2006)
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
T Kawai et al.
NATURE IMMUNOLOGY (2005)
VISA is an adapter protein required for virus-triggered IFN-β signaling
LG Xu et al.
MOLECULAR CELL (2005)
Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-κB and IRF3
RB Seth et al.
CELL (2005)
Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity
M Yoneyama et al.
JOURNAL OF IMMUNOLOGY (2005)
Toll-like receptor 3 promotes cross-priming to virus-infected cells
O Schulz et al.
NATURE (2005)
Identification of 2′-phosphodiesterase, which plays a role in the 2-5A system regulated by interferon
K Kubota et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-β promoter
J Andrejeva et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Sensitivity of hepatitis C virus RNA to the antiviral enzyme ribonuclease L is determined by a subset of efficient cleavage sites
JQ Han et al.
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH (2004)
Subcellular localization of toll-like receptor 3 in human dendritic cells
M Matsumoto et al.
JOURNAL OF IMMUNOLOGY (2003)
Identification of Lps2 as a key transducer of MyD88-independent TIR signalling
K Hoebe et al.
NATURE (2003)
The dsRNA binding protein family: critical roles, diverse cellular functions
LR Saunders et al.
FASEB JOURNAL (2003)
Triggering the interferon antiviral response through an IKK-related pathway
S Sharma et al.
SCIENCE (2003)
Human telomerase and its regulation
YS Cong et al.
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2002)
Overexpression of helicard, a CARD-containing helicase cleaved during apoptosis, accelerates DNA degradation
M Kovacsovics et al.
CURRENT BIOLOGY (2002)
mda-5:: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties
DC Kang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
L Alexopoulou et al.
NATURE (2001)