Journal
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
Volume 13, Issue 2, Pages 378-385Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s13346-022-01232-4
Keywords
Gold nanoparticles; Gold nanoconstructs; Nanomedicine; Clinical trials; Drug delivery; Photothermal therapy
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Gold nanoparticles with unique physicochemical features are being investigated for therapeutic purposes. After two decades of preclinical progress, gold nanoconstructs are transitioning into clinical trials. The current consensus is to focus on specific disorders for therapeutic applications.
Gold nanoparticles display unique physicochemical features, which can be useful for therapeutic purposes. After two decades of preclinical progress, gold nanoconstructs are slowly but steadily transitioning into clinical trials. Although initially thought to be magic golden bullets that could be used to treat a wide range of diseases, current consensus has moved toward a more realistic approach, where gold nanoformulations are being investigated to treat specific disorders. These therapeutic applications are dictated by the pharmacokinetics and biodistribution profiles of gold nanoparticles. Here, we analyze the current clinical landscape of therapeutic gold nanoconstructs, discuss the shared characteristics that allowed for their transition from bench to bedside, and examine existing hurdles that need to be overcome before they can be approved for clinical use.
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