Journal
CARCINOGENESIS
Volume 36, Issue -, Pages S203-S231Publisher
OXFORD UNIV PRESS
DOI: 10.1093/carcin/bgv037
Keywords
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Funding
- United States National Institute of Environmental Health Sciences
- United States Department of Veterans Affairs
- Fondazione Cariplo [2011-0370]
- Rosemere Cancer Foundation
- Kuwait Institute for the Advancement of Sciences [2011-1302-06]
- Grant University Scheme (RUGs) Ministry Of Education Malaysia [04-02-12-2099RU]
- Italian Ministry of University and Research [2009FZZ4XM_002]
- University of Florence
- United States Public Health Service [CA92306, CA92306-S1, CA113447, ES010356]
- Department of Science and Technology, Government of India [SR/FT/LS-063/2008]
- Associazione Italiana per la Ricerca sul Cancro [IG2014Id.15364]
- SYSBIO Fellowship
- MIUR Fellowship
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Dysregulated metabolism represents one of the most common and recognizable features of cancer. Specific roles for metabolic reprogramming in environmental carcinogenesis, however, remain incompletely delineated. The present review addresses corresponding knowledge gaps and the limitations of current experimental approaches to the problem.Environmental contributions to cancer development are widely accepted, but only a fraction of all pertinent exposures have probably been identified. Traditional toxicological approaches to the problem have largely focused on the effects of individual agents at singular endpoints. As such, they have incompletely addressed both the pro-carcinogenic contributions of environmentally relevant low-dose chemical mixtures and the fact that exposures can influence multiple cancer-associated endpoints over varying timescales. Of these endpoints, dysregulated metabolism is one of the most common and recognizable features of cancer, but its specific roles in exposure-associated cancer development remain poorly understood. Most studies have focused on discrete aspects of cancer metabolism and have incompletely considered both its dynamic integrated nature and the complex controlling influences of substrate availability, external trophic signals and environmental conditions. Emerging high throughput approaches to environmental risk assessment also do not directly address the metabolic causes or consequences of changes in gene expression. As such, there is a compelling need to establish common or complementary frameworks for further exploration that experimentally and conceptually consider the gestalt of cancer metabolism and its causal relationships to both carcinogenesis and the development of other cancer hallmarks. A literature review to identify environmentally relevant exposures unambiguously linked to both cancer development and dysregulated metabolism suggests major gaps in our understanding of exposure-associated carcinogenesis and metabolic reprogramming. Although limited evidence exists to support primary causal roles for metabolism in carcinogenesis, the universality of altered cancer metabolism underscores its fundamental biological importance, and multiple pleiomorphic, even dichotomous, roles for metabolism in promoting, antagonizing or otherwise enabling the development and selection of cancer are suggested.
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