Journal
ADVANCED SCIENCE
Volume 9, Issue 33, Pages -Publisher
WILEY
DOI: 10.1002/advs.202202933
Keywords
acute kidney injury; covalent modification; germanene nanosheets; inorganic antioxidants; reactive oxygen species
Categories
Funding
- National Natural Science Foundation of China [52002391, 21835007]
- Young Elite Scientists Sponsorship Program by China Association for Science and Technology (CAST) [2021QNRC001]
- Shanghai Science and Technology Committee Rising-Star Program [22QA1410200]
- Key Research Program of Frontier Sciences, Chinese Academy of Sciences [ZDBS-LY-SLH029]
- Basic Research Program of Shanghai Municipal Government [21JC1406000]
- Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences [2021-I2M-5-012]
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This study reports the use of hydrogen-terminated germanene nanosheets as an antioxidative defense nanoplatform against acute kidney injury (AKI). The results show that H-germanene can effectively scavenge reactive oxygen species (ROS) and accumulate in injured kidneys, providing a potential treatment option for renal diseases.
Acute kidney injury (AKI) is a sudden kidney dysfunction caused by aberrant reactive oxygen species (ROS) metabolism that results in high clinical mortality. The rapid development of ROS scavengers provides new opportunities for AKI treatment. Herein, the use of hydrogen-terminated germanene (H-germanene) nanosheets is reported as an antioxidative defense nanoplatform against AKI in mice. The simulation results show that 2D H-germanene can effectively scavenge ROS through free radical adsorption and subsequent redox reactions. In particular, the H-germanene exhibits high accumulation in injured kidneys, thereby offering a favorable opportunity for treating renal diseases. In the glycerol-induced murine AKI model, H-germanene delivers robust antioxidative protection against ROS attack to maintain normal kidney function indicators without negative influence in vivo. This positive in vivo antioxidative defense in living animals demonstrates that the present H-germanene nanoplatform is a powerful antioxidant against AKI and various anti-inflammatory diseases.
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