Journal
ADVANCED SCIENCE
Volume 9, Issue 30, Pages -Publisher
WILEY
DOI: 10.1002/advs.202202920
Keywords
cyanobacteria; myocardial infarction; oxygen; photoresponse
Categories
Funding
- National Natural Science Foundation of China [31860263, 81760408]
- National Key Research and Development Program of China [2020YFC2005800]
- Key Youth Project of Jiangxi Province [20202ACB216002]
- Natural Science Foundation of Jiangxi Province [20113BCB22005, 20181BCG42001]
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A photoresponsive upconversion cyanobacterium nanocapsule has been developed for the prevention and treatment of MI, with the potential to provide a highly effective and targeted approach.
Myocardial infarction (MI) is a common disease that seriously threatens human health. It is noteworthy that oxygen is one of the key factors in the regulation of MI pathology procession: the controllable hypoxic microenvironment can enhance the tolerance of cardiac myocytes (CMs) and oxygen therapy regulates the immune microenvironment to repair the myocardial injury. Thus, the development of an oxygen-controllable treatment is critically important to unify MI prevention and timely treatment. Here, a hydrogel encapsulated upconversion cyanobacterium nanocapsule for both MI prevention and treatment is successfully synthesized. The engineered cyanobacteria can consume oxygen via respiration to generate a hypoxic microenvironment, resulting in the upregulation of heat shock protein70 (HSP70), which can enhance the tolerance of CMs for MI. When necessary, under 980 nm near-infrared (NIR) irradiation, the system releases photosynthetic oxygen through upconversion luminescence (UCL) to inhibit macrophage M1 polarization, and downregulates pro-inflammatory cytokines IL-6 and tumor necrosis factor-alpha (TNF-alpha), thereby repairing myocardial injury. To sum up, a photoresponsive upconversion cyanobacterium nanocapsule is developed, which can achieve MI prevention and treatment for only one injection via NIR-defined respiration and photosynthesis.
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