4.8 Article

Periplasmic Bacterial Biomineralization of Copper Sulfide Nanoparticles

Journal

ADVANCED SCIENCE
Volume 9, Issue 28, Pages -

Publisher

WILEY
DOI: 10.1002/advs.202203444

Keywords

biologically-controlled biomineralization; copper sulfide; cryo-electron tomography; intracellular biomineralization; magnetotactic bacteria; proteomics

Funding

  1. CEA via a CFR doctoral fellowship
  2. European Union Marie-Sklodowska Curie Action International Fellowship (MSCA-IF Project) [797431]
  3. National Office for Research, Development and Innovation (Hungary) [NKFIH-471-3/2021]
  4. Marie Curie Actions (MSCA) [797431] Funding Source: Marie Curie Actions (MSCA)

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This study reports the periplasmic biomineralization of copper sulfide nanoparticles produced by the magnetotactic bacterium Desulfamplus magnetovallimortis strain BW-1. It reveals previously unknown possibilities for intracellular biomineralization and holds promise for biological metal recovery.
Metal sulfides are a common group of extracellular bacterial biominerals. However, only a few cases of intracellular biomineralization are reported in this group, mostly limited to greigite (Fe3S4) in magnetotactic bacteria. Here, a previously unknown periplasmic biomineralization of copper sulfide produced by the magnetotactic bacterium Desulfamplus magnetovallimortis strain BW-1, a species known to mineralize greigite (Fe3S4) and magnetite (Fe3O4) in the cytoplasm is reported. BW-1 produces hundreds of spherical nanoparticles, composed of 1-2 nm substructures of a poorly crystalline hexagonal copper sulfide structure that remains in a thermodynamically unstable state. The particles appear to be surrounded by an organic matrix as found from staining and electron microscopy inspection. Differential proteomics suggests that periplasmic proteins, such as a DegP-like protein and a heavy metal-binding protein, could be involved in this biomineralization process. The unexpected periplasmic formation of copper sulfide nanoparticles in BW-1 reveals previously unknown possibilities for intracellular biomineralization that involves intriguing biological control and holds promise for biological metal recovery in times of copper shortage.

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