Journal
NANOMATERIALS
Volume 12, Issue 17, Pages -Publisher
MDPI
DOI: 10.3390/nano12172905
Keywords
hemicyanine; photosensitizer; supramolecular assembly; photodynamic therapy
Categories
Funding
- Beijing Municipal Education Commission project [KM202210011002]
- Fundamental Research Funds for the Central Universities [FRF-IDRY-20-026]
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An intelligent antimicrobial switch has been developed to reduce prolonged exposure of pathogenic bacteria to antibiotics. This switch can control the antimicrobial activity of hemicyanines, effectively preventing the development of antibiotic resistance.
An intelligent antimicrobial switch has been constructed to reduce prolonged exposure of pathogenic bacteria to antibiotics, which could reversibly turn off or turn on the antimicrobial activity of hemicyanines through self-assembly or dis-assembly of cucurbit[7]uril (CB[7]). This assembly effectively inhibited the production of ROS under light, shielding the active site of hemicyanines and achieving on-demand antimicrobial ability. Moreover, CB[7] differentially inhibits ROS of molecules with different alkyl chain lengths, which provided reference for the subsequent design of materials with antimicrobial activity regulation, and could effectively delay or even prevent the development of pathogens resistance.
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